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Validated All-in-One™ qPCR Primer for TCF7L2(NM_001146274.2) Search again
Product ID:
HQP161744
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
TCF-4, TCF4
Gene Description:
transcription factor 7 like 2
Target Gene Accession:
NM_001146274.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The TCL7L2 gene product is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. (2005) [PubMed 15525634] suggested that TCL7L2 acts through regulation of proglucagon (MIM 138030) through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway.[supplied by OMIM].
Gene References into function
- tcf4 can specifically recognize beta-catenin using alternative conformations
- crystal structure of a human Tcf4-beta-catenin complex; comparison with recent structures of beta-catenin in complex with Xenopus Tcf3 (XTcf3) and mammalian E-cadherin
- Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of epithelial origin.
- Activation of AXIN2 expression by beta-catenin-T cell factor
- Functional MDR1 polymorphisms (G2677T and C3435T) and TCF4 mutations in colorectal tumors with high microsatellite instability
- ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation
- role of TCF-4 upon transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in human astrocytic cells
- The high expression level of hTcf-4 in HCC, especially with metastasis, suggests that the over-expression of hTcf-4 gene may be closely associated with development and progression of HCC, but the mutation of this gene plays a less important role
- disruption of beta-catenin/TCF-4 activity in CRC cells induces a rapid G1 arrest and blocks a genetic program that is physiologically active in the proliferative compartment of colon crypts.
- the C terminus of TCF4E cooperates with beta-catenin and p300 to form a specialized transcription factor complex that specifically supports the activation of the Cdx1 promoter
- there is a direct interaction between the androgen receptor DNA binding domain (DBD) and Tcf4.
- TCF-4N inhibits coactivation by beta-catenin of TCF/LEF transcription factors and potentiates the coactivation by beta-catenin of other transcription factors, such as SF-1 and C/EBPalpha
- TCF4 could be an effective therapeutic target for suppressing the growth of hepatocellular cancers.
- TCF4-binding element was identified in PTTG promoter region in eesophageal squamous cell sscarscinomsa.
- identify selective beta-catenin binding hot spots of Tcf4, E-cadherin, and APC
- Together, we suggest that quercetin is an excellent inhibitor of beta-catenin/Tcf signaling in SW480 cell lines, and the reduced beta-catenin/Tcf transcriptional activity is due to the decreased nuclear beta-catenin and Tcf-4 proteins.
- TCF4 expression mediated by beta-catenin/p300 may be important for initial steps during trans-differentiation of endometrial carcinoma cells.
- The regulation of GLCE expression by 2 cis-acting elements of the beta-catenin-TCF4 complex located in the enhancer region of the promoter are reported.
- characterization of the TCF4 with microsatellite instability (MSI) in colon cancer and leukemia cell lines; results delineate a novel role for MSI+TCF4 in leukemia and colon cancer progression
- the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/beta-catenin, two distinct pathways activated by WNT signalling
- TIS7, a negative regulator of transcriptional activity, represses expression of OPN and beta-catenin/Tcf-4 target genes
- The positive inter-regulation between beta-cat/Tcf-4 signaling and ET-1 signaling potentiates proliferation and survival of prostate cancer (CaP) cells, thereby representing a novel mechanism that contributes to CaP progression.
- Presenilin-1association with plakoglobin enhances the interaction of this molecule with Tcf-4 and prevents its binding to DNA.
- results suggest an established Wnt signaling pathway in most gastric cancers, a close correlation of beta-catenin/TCF4-mediated signaling with tumor dissemination, and the unlikelihood of a direct effect of activated Wnt signaling on CD44 expression
- Suggestive linkage of type 2 diabetes mellitus to TCFL2 protein on chromosome 10q.
- Represses Wnt signaling in breast tissue, and its downregulation contributes to the activation of Wnt signaling.
- A role is suggested for TCF7L2 frameshift mutation during MSI-H colorectal tumor progression, by regulating the relative proportion of the different TCF7L2 isoforms.
- Daxx reduced DNA binding activity of Tcf4 and repressed Tcf4 transcriptional activity.
- findings suggest that activity at the HIV-1 promoter is influenced by phosphorylation of Sp1, which is affected by Tat and DNA-PK; interactions among TCF-4, Sp1 and/or Tat may determine the level of viral gene transcription in astrocytic cells
- evidence provided that HIC1 antagonizes the TCF/beta-catenin-mediated transcription in Wnt-stimulated cells; this appears to be due to the ability of HIC1 to associate with TCF-4 and to recruit TCF-4 and beta-catenin to the HIC1 bodies
- Common variants (rs12255372 and rs7903146) in TCF7L2 seem to be associated with an increased risk of diabetes among persons with impaired glucose tolerance
- These data provide replicating evidence that variants in TCF7L2 increase the risk for type 2 diabetes and novel evidence that the variants likely influence both insulin secretion and insulin sensitivity.
- These results suggest that TCF7L2 variants may act through insulin secretion to increase the risk of type 2 diabetes.
- These data provide evidence that TCF7L2 is a major determinant of type 2 diabetes risk in European populations and suggests that this transcription factor plays a key role in glucose homeostasis.
- Combining information from several known common risk polymorphisms allows the identification of population subgroups with markedly differing risks of developing type 2 diabetes compared to those obtained using single polymorphisms.
- Variants of the TCF7L2 gene contribute to the risk of type 2 diabetes. The population-attributable risk from this factor in the Dutch type 2 diabetes population is 10%.
- crystallographic analysis of how beta-catenin, BCL9, BCL9-2 and Tcf4 interact
- Although TCF7L2 is a major gene in type 2 diabetes, there is no evidence for association between this gene and type 1 diabetes.
- TCF7L2 T at-risk allele variation predicts hyperglycemia incidence in a general French population, possibly through a deleterious effect on insulin secretion.
- A high mobility group box-containing TCF7L2 leads to diabetes risk.
- No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus was found in this study in French white subjects.
- TCF7L2 is an important gene for determining susceptibility to type 2 diabetes mellitus and it transgresses the boundaries of ethnicity.
- results suggest a possible influence of TCF7L2 rs12255372 on the risk of familial breast cancer
- TCF7L2 gene is an important factor regulating insulin secretion, which could explain its association with type 2 diabetes.
- AXIN1, AXIN2 and TCF7L2 may have roles in development of colorectal carcinomas [review]
- polymorphism is associated with lower insulin levels, smaller waist circumference, and lower risk lipid profiles in the general elderly population.
- TCF7L2 variants increase type 2 diabetes risk and may affect pancreatic beta cell function.
- Several single nucleotide polymorphisms are associated with type 2 diabetes.
- TCF7L2 is a common susceptibility gene for type 2 diabetes in the Japanese population
- data provide evidence that variation in the TCF7L2 genomic region may affect risk for type 2 diabetes in Mexican Americans, but the attributable risk may be lower than in Caucasian populations
- Variation in TCF7L2 is associated with gestational diabetes and interacts with adiposity to alter insulin secretion in Mexican Americans.
- May be a strong candidate for conferring susceptibility to type 2 diabetes across different ethnicities in Japan.
- Variant is associated with an increased risk of gestational diabetes mellitus in Scandinavian women.
- combined effect of obesity and genotype in predicting type 2 diabetes risk in a sample of French Canadian cardiac patients. in predicting type 2 diabetes risk in a sample of French Canadian cardiac patients.
- Transcription factor 4 (TCF-4), the downstream effector of Wnt signaling, is implicated in repressing HIV replication in astrocytes.
- findings suggest that the TCF7L2 risk allele may predispose to type 2 diabetes by impairing beta-cell proinsulin processing
- Variants of TCF7L2 may be associated with increased disease severity and therapeutic failure in diabetes.
- A cariant of TCF7L2 is associated with incident type 2 diabetes in a separate population-based cross-sectional study.
- evaluated the association of the three TCF7L2 polymorphisms with NIDDM by using the program admixmap to fit a logistic regression model incorporating individual ancestry, sex, age, body mass index and education
- Study assessed role of TCF4 in birth weight.
- TCF7L2 variants influence therapeutic response to sulfonylureas but not metformin
- an increased risk of type 2 diabetes is associated with TCF7L2 rs7903146 genotype.
- The discovery of TCF7L2 as a diabetes gene illustrates that novel true diabetes genes can be found, their association with type 2 diabetes replicated and their effect incorporated into risk prediction models (Review)
- TCF7L2 genetic polymorphisms are major determinants for risk of type 2 diabetes in the Chinese population.
- Results confirmed TCF7L2 as a risk factor in a population of European descent, where it reduced glucose tolerance and insulin sensitivity, but not insulin secretion.
- TCF7L2 rs7903146 variant neither increases the risk for SGA nor modulates birth weight and young adulthood glucose homeostasis in French Caucasian subjects born with SGA
- Variations in the TCF7L2 gene significantly contribute to diabetes susceptibility in African-American populations.
- Variations at TCF7L2 contribute to Type 2 diabetes.
- Odds ratio for single nucleotide polymorphisms associated with plasma proinsulin, beta cell dysfunction and increased risk of type 2 diabettes.
- Novel mutations in exon 4 of hTCF-4 gene were revealed in this study, which might be of importance in the pathogenesis of sporadic rectal cancer patients with high frequency microsatellite instability.
- Variants of TCF7L2 specifically impair GLP-1-induced insulin secretion.
- Common variants in the TCF7L2 gene and its predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women are reported.
- the increased risk of type 2 diabetes conferred by variants in TCF7L2 involves the enteroinsular axis, enhanced expression of the gene in islets, and impaired insulin secretion.
- TCF7L2 does not participate in the etiology of Type 1 diabetes
- The genetic susceptibility from the TCF7L2 gene variation is a unique mechanism of type 2 diabetes (T2D), and is not shared by type 1 diabetes (T1D).
- The rs12255372(G/T) and rs7903146(C/T) polymorphisms of TCF7L2 gene confer susceptibility to type 2 diabetes mellitus in Asian Indians.
- A reduced expression in ileal Crohn's disease of the Wnt-signaling pathway transcription factor Tcf-4, a known regulator of Paneth cell differentiation and alpha-defensin expression, was reported.
- common variation in the TCF7L2 gene contributes to Type 2 diabetes risk in UK patients recruited in general practice, but the risk allele frequency may be lower than that in subjects enriched for genetic effects
- Overexpression of TCF-4 is associated with the development of lung cancer
- Establishing whether variation in TCF7L2 also influences the development of polycystic ovary syndrome and type 2 diabetes.
- Data indicate that Sox4 and 17 can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts.
- TCF7L2 (transcription factor 7-like 2) has been identified as a gene for type 2 diabetes.
- Variation within TCF7L2 does not confer major risk for type 2 diabetes among the Pima Indian population.
- TCF7L2 rs7903146 genetic variation is associated with an increased risk of post transplantation diabetets mellitus in renal allograft recipients.
- TCF7L2 variants could play a role in the pathogenesis of type 2 diabetes mellitus in the Hispanic American population through a mchanism involving insulin secretion.
- Topo IIalpha interacts with beta-catenin/T-cell factor-4 as a novel transcriptional co-activator in colorectal neoplasms.
- MTG family members associate specifically with TCF4. Coexpression of beta-catenin disrupted the association between these corepressors and TCF4.
- Ectopic expression of Dkk3 in lung cancer cells with Dkk3 hypermethylation induced apoptosis and inhibited TCF-4 activity
- The role of TCF7L2 in beta-cell function and survival in cultured cells is reported.
- DG10S478 variant seems to have no influence on manifestation of diabetes and the development of microvascular complications.
- Single nucleotide polymorphisms in TCF7L2 were associated with type 2 diabetes
- A precise and reproducible electrophoretic technique is used to make an allelic assignment from genomic DNA of the polymorphism in microsatellite DG10S478 of TCF7L2.
- myostatin enhanced nuclear translocation of beta-catenin and formation of the Smad3-beta-catenin-TCF4 complex, together with the altered expression of a number of Wnt/beta-catenin pathway genes in hMSCs
- TCF7L2 is not a risk factor for obesity in European populations, but its effect on type 2 diabetes risk is modulated by obesity.
- Diabetes-associated variants in TCF7L2 and CDKAL1 impair insulin secretion and conversion of proinsulin to insulin.
- TCF4-binding regions significantly correlate with Wnt-responsive gene expression profiles derived from primary human adenomas
- Subjects who were initially cancer-free and carrying certain genetic variants of TCF7L2 have an increased risk of colon cancer.
- TCF7L2 variants are associated with increased risk for diabetes mellitus in Emirati subjects.
- TCF7L2 rs7903146 T allele is present in obese hypertensive patients as much as in the general population.
- TCF7L2 is an important genetic risk factor for the development of type 2 diabetes in multiple ethnic groups
- The TCF7L2 gene may alter risk of developing more aggressive prostate cancer.
- TCF7L2 mRNA levels in adipocytes are decreased by insulin and seem to increase in insulin resistant subjects and in HapA carriers.
- We confirm that c-Jun functions in canonical Wnt signaling and show that c-Jun functions as a scaffold in the beta-catenin-TCFs transcription complex bridging Dvl to TCF.
- TCF7L2 gene is a major risk factor for development of T2DM in Khatri Sikhs from North India.
- These data suggest that colon cancer risk associated with the rs7903146 TCF7L2 polymorphism is modified by use of aspirin/NSAIDs
- Increased health risk associated with an rs7903146 genotype is specific to mortality in diabetes and diabetic angiopathies.
- Determination of role nuclear pore complex in regulating TCF4/beta cateninin mediated Wnt signaling.
- Data show that one TCF7L2 SNP (rs7903146) showed compelling evidence of association with type 2 diabetes in African Americans.
- association of TCF7L2 with type 2 diabetes [review]
- Data confirmed the associations of single nucleotide polymorphisms in TCF7L2 with risk for type 2 diabetes in Asians.
- there was suggestive evidence for an inverse association associated of colorectal cancer and ademoma with homozygosity for the minor allele of RS12255372 (TCF7L2 TT) and conditional and covariate adjusted risk 0for heterogeneity for in women and men
- we did not find any mutation in the coding sequence of TCF7L2 that confers a genetic risk for type 2 diabetes in a Chinese population
- results indicate that Tcf-4 maintains low levels of claudin-7 at the bottom of colonic crypts, acting via Sox-9
- genetic variants in TCF7L2 confer a strong risk of future type 2 diabetes possibly mediated by altering expression of TCF7L2 in pancreatic islets [review]
- The higher homeostasis model assessment insulin resistance index (HOMA-B%) index in TT-homozygotes indicates TCF7L2 to be a susceptibility gene for the development of impaired glucose tolerance in obese children.
- Gene variants of CDKAL1, PPARG, IGF2BP2, HHEX, TCF7L2, and FTO predispose to type 2 diabetes in the German KORA 500 K study population.
- TCF7L2 SNPs revealed a significant association with type 2 diabetes
- The primary defect of rs7903146 T-allele carriers is impairment of insulin secretion rather than a defect in insulin action in peripheral tissues.
- the presumed cancer-promoting gene TCF7L2 functions instead as a transcriptional repressor that restricts colorectal cancer (CRC) cell growth.
- variants in the TCF7L2 gene are associated with reduced kidney function and CKD progression
- Our study is consistent with weak or no association of type 2 diabetes in Arabs with the two TCF7L2 variants
- Study show that polymorphisms in TCF7L2 were associated with type 2 diabetes risk in the studied population.
- TCF7L2 mRNA expression is fat-depot specific but does not seem to provide the mechanistic link explaining genetic association with type 2 diabetes mellitus.
- co-existence of TCF7L2 variants and the SPINK1 and CTSB mutations, that predict susceptibility to exocrine damage, may interact to determine the onset of diabetes in TCP patients
- Evidence that the TCF7L2 gene is a major determinant of type 2 diabetes risk in Spain, as in other southern Eutopean populations.
- Frameshift mutations of Wnt pathway genes AXIN2 and TCF4 in gastric carcinomas with high microsatellite instability are reported.
- Nine novel deletion mutations in TCF4 in Pitt-Hopkins Syndrome are described.
- Common variants in the TCF7L2 gene help to differentiate young but not middle-aged glutamic acid decarboxylase antibodies(GADA)-positive and GADA-negative diabetic patients
- The rs7903146 variant of the TCF7L2 gene might influence PCOS predisposition, while no association is observed between the E23K variant of KCNJ11 and susceptibility to PCOS and related traits.
- Common coding variant in the TCF7L2 gene is associated with type 2 diabetes.
- TCF7L2 rs7903146 T allele is associated with a 1.57 increased risk for type 2 diabetes in a Brazilian cohort of patients with known coronary heart disease
- TCF7L2 CT/TT genotype is more frequent in nonalcoholic fatty liver disease and predicts the presence and severity of liver disease.
- High polyunsaturated fatty acid intakes were associated with atherogenic dyslipidemia in carriers of the minor T allele at the TCF7L2 single nucleotide polymorphism.
- This meta-analysis demonstrates that four variants of TCF7L2 gene are all associated with type 2 diabetes mellitus, and indicates a multiplicative genetic model for all the four polymorphisms [review]