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Validated All-in-One™ qPCR Primer for TAC1(NM_013997.3) Search again
Product ID:
HQP161578
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
Hs.2563, NK2, NKNA, NPK, TAC2
Gene Description:
tachykinin precursor 1
Target Gene Accession:
NM_013997.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Gene References into function
- We report on an HD phenocopy with selective loss of preprotachykinin (PPT) neurons, dysfunction of surviving PPT neurons, preservation of preproenkephalin (PPE) neurons within the striatum.
- Involvement of the second extracellular loop (E2) of the neurokinin-1 receptor in the binding of substance P
- Substance P up-regulates the TGF-beta 1 mRNA expression of human dermal fibroblasts in vitro
- Substance P induced intracellular signalling in Caco-2 cells. It induced the activation of the mitogen-activated protein kinases in a time- and dose-dependent manner.
- REVIEW: Substance p-fibronectin-cytokine interactions in myeloproliferative disorders with bone marrow fibrosis.
- Substance P is expressed in human articular cartilage and is involved in chondrocyte mechanotransduction via the NK1 receptor in an autocrine and paracrine manner.
- Substance P expressed in NT2-N neuronal cells is functionally involved in the regulation of macrophage inflammatory protein 1 beta and may play a major role in modulating neuronal functions related to immune regulatory activities within the CNS.
- The release of substance P is higher during the first 12 hours after a cerebral ischemia attack, decreasing later but remaining high compared to controls.
- a role for substance P and its receptor, neurokinin NK(1) receptor, in the brainstem nuclei in the development of emesis (review)
- Expression of substance P was studied in neoplastic cells of childhood acute lymphocytic leukemia. It was detected in the cytoplasm of blasts in leukemias of the common and T-lymphocyte cell types.
- correlation between SP levels and diarrhea severity in cryptosporidiosis; may imply that SP plays a role in diarrhea mediation
- This review points out a distinct role for full-length peptide substance P by reducing excessive excitation in the activity-dependent modulation of cholinergic neurotransmission.
- substance P receptor dimerization with micro-opioid receptor, sequestering MOR-1 via an endocytotic pathway with delayed recycling and resensitization kinetics.
- Elevated substance P in nasal lavage fluid associated with increased cough sensitivity in patients with chronic nonproductive cough. Neurochemical abnormality in upper airway.
- Presence of substance P within these nerves is strong evidence that these nerves have the potential to transmit signals of nociception.
- Normal component of human tears. Levels might reflect denervation of eye surface. Catabolized by degradative enzymes in tears to maintain ocular surface by exerting trophic effects of substance P while avoiding undesirable effects.
- The contents of plasma neurokinin A (NKA) were significantly higher during the asthma attack stage of children, and the higher was the level of NKA, the more severe the attack.
- SP stimulates platelet aggregation, intracellular mobilization of calcium and degranulation. Platelets contain SP-like immunoreactivity that is secreted upon activation implicating SP-like substances in the autocrine/paracrine regulation of these cells.
- certain bioactive peptides such as somatostatin and substance P directly interact with human P-glycoprotein as endogenous substrates for P-glycoprotein-mediated transport
- data directly demonstrate the presence of both PPT-A mRNA and tachykinin immunoreactivity in inflammatory airway cells which are in direct contact to NK-1 receptor positive glandular myoepithelium
- Preprotachykinin-I peptides mediate autocrine proliferation of the neuroblastoma cells through both NK-1 and NK-2 receptors.
- Prresence in pituitary tumours is unknown but does not appear to be related to headache or endocrine activity of the tumour.
- Bombesin/gastrin-releasing peptide and substance P are involved together with cytokines in the neuroimmunomodulation that occurs in the arthritic joint.
- The increase in plasma SP concentrations, possibly driven by serum progesterone concentration, is certainly an important element of the hypothalamo-pituitary-gonadal system necessary for the full development of the preovulatory LH surge in the human.
- Activation of STAT6 appears to be a key factor in P-selectin expression induced by substance P and IL-4 because treatment with STAT6 decoy oligodeoxynucleotides significantly inhibited P-selectin expression.
- SST and TAC1 are involved in colon carcinogenesis.
- Increase in AngII and decrease in substance P after coronary artery bypass grafting may play role in occurrence of postoperative atrial fibrillation.
- Possesses antiapoptotic effects in the colonic mucosa by activating Akt, which prevents apoptosis and mediates tissue recovery during colitis.
- Nonneuronal substance P and its receptor NK-1 might have a role in psoriasis, also during chronic stress.
- the TAC1 locus is not likely to play a major role in the development of autism.
- NF-kappaB is involved in the repression of Tac1 at higher levels of SDF-1alpha in MCF12A. These results are relevant to dysfunction of Tac1 in breast cancer cells.
- Substance P and Titanium particles acted synergistically to increase PGE2 and IL-6 secretion in fibroblasts from periprosthetic membrane.
- We concluded that excessive daytime sleepiness seen in some of the obstructive sleep apnea syndrome patients might be associated with various pathophysiologic mechanisms including substance P levels.
- These findings suggest the novel possible role of SP in blasts proliferation in childhood ALL of common (CD10) origin.
- Substance P was elevated in obstructive sleep apnea.
- there is synergism between REST and NFkappaB in the suppression of TAC1 in non-neuronal cells
- neurotransmitter substance P is regulated by microRNAs in human mesenchymal stem cell-derived neuronal cells
- there are two proposed mechanisms for severe hRSV disease: reduced local IFN-gamma response and SP mediated inflammation
- Report modulation of substance P signaling by dipeptidyl peptidase-IV enzymatic activity in human glioma cell lines.
- TAC1 promoter hypermethylation is a common event in human esophageal carcinoma
- The broad categories of cytokines as hematopoietic stimulators or inhibitors might depend on the avidity of RNA-binding protein(s) for Tac1 mRNA, as well as the ability to degrade or stabilize the specific miRNAs
- In gingival fibroblast cells induced up-regulation of MMP-1, -3, -11 and TIMP-2 expression
- Specific changes in CGRP and substance P at different levels of the central nervous system in the different models of pain (formalin test and nitroglycerin administration).
- Substance P plasma level in atopic dermatitis patients during exacerbation and remission was significantly higher than in the control group.
- both SP and bombesin is be present in synovial tissue extracts and synovial levels of SP were higher in rheumatoid arthritis patients than those with osteoarthritis
- Tac1 is relevant to breast cancer metastasis, to bone marrow where stromal cells have a significant facilitating function.
- Sputum NKA is up-regulated during acute asthma exacerbation and it positively correlates to its severity.
- SP mediates angiogenesis via CCN1 during colitis.
- Pregabalin and gabapentin decreased substance P-induced NF-kappaB activation in human neuroblastoma and rat glioma cells
- The change in expression of sNRSF and TAC1 mRNA following mechanical stimulation in osteoarthritic (OA) but not normal chondrocytes suggests that sNRSF may be involved in the regulation of substance P production in OA cartilage.
- Evidence presented strongly supporting a role for the neuroendocrine peptide gene TAC1 as a target of aberrant epigenetic silencing in gastric cancer.