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Validated All-in-One™ qPCR Primer for SYK(NM_001174167.3) Search again
Product ID:
HQP161553
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
IMD82, p72-Syk
Gene Description:
spleen associated tyrosine kinase
Target Gene Accession:
NM_001174167.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- Syk kinase is required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis leading to particle uptake by the receptor-bearing monocyte or neutrophil.
- Syk kinase physically and functionally associates with the IL-15R alpha chain in B cells and plays a key role in mediating IL-15-induced signal transduction.
- Primary arrest of circulating platelets on collagen involves phosphorylation of Syk, cortactin and focal adhesion kinase
- Syk/hSlo interaction does not affect the electrical features of BK channels in osteosarcoma cells.
- Proteasome-dependent regulation of Syk tyrosine kinase levels in basophils
- actin-linking proteins moesin and ezrin directly interact with Syk in an ITAM-dependent manner
- mechanism of IL-2-activated SYK regulation of Akt-dependent cell survival in NK cells
- Our data suggest that reduced Syk expression in breast cancers is associated with distant metastasis and poor prognosis.
- This protein suppresses the cell motility and nuclear factor kappa B-mediated secretion of urokinase type plasminogen activator by inhibiting the phosphatidylinositol 3'-kinase activity in breast cancer cells.
- Syk kinase is up-regulated specifically in activated/effector T cells generated by stimulation with anti-CD3 or antigen, and perhaps may serve as both novel indicator for immune activation and target for manipulation of ongoing immune responses.
- H2O2 induces NF-kappaB activation, not through serine phosphorylation or degradation of IkappaBalpha, but through Syk-mediated tyrosine phosphorylation of IkappaBalpha
- Nuclear Syk possesses biological activities associated with tumor suppression in mammary epithelial cells.
- "Syk was first isolated and characterized by Zioncheck et al. and is known to be associated with high affinity IgE receptor...and involved in the signaling pathway after cross-linking of this receptor by antigen in mast cells and basophils." p. 1685
- role in lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils
- Hypermethylation leads to lose of the syk gene expression in human breast carcinoma and may be correlated to oncogenesis, metastasis of breast carcinoma.
- The interplay between Syk and ZAP-70 in thymocytes, certain T cells, and B-chronic lymphocytic leukemia cells will modulate the amplitude of antigen-mediated receptor signaling.
- The expression of the Syk gene may play an important role in suppressing growth and metastasis of breast cancer.
- A Syk-dependent signaling cascade controls anti-myeloperoxidase IgM ANCA-dependent neutrophil adhesion and apoptosis.
- data indicate that Syk kinase plays an important role in the translocation of hematopoietic lineage cell-specific protein 1 (HS1) into lipid rafts
- Methylation of Syk promoter is correlated to oncogenesis and metastasis of gastric carcinoma.
- Syk acts a negative control element of EGFR signalling.
- x-ray structure of spleen tyrosine kinase bound to Gleevec
- C-terminal SH2 domain of p85 PI-3 kinase was sufficient for mediating an interaction with tyrosine-phosphorylated Syk
- propose that Syk is involved in signaling pathways induced by integrin engagement in airway epithelial cells; Syk-mediated signaling regulates IL-6 and ICAM-1 expression and may be important in the pathophysiology of lung inflammation
- there is a complex interplay between PKCalpha, Syk, and Src involving physical interaction, phosphorylation, translocation within the cell, and functional activity regulation
- Results demonstrated that the lysosomal change accompanied with the activation of lysosomal enzymes is a primary step in BCR-crosslinking-mediated apoptosis and Syk is responsible for this step through the fusion of BCR-carrying endosomes to lysosomes.
- c-Cbl plays a regulatory role in glycoprotein VI (GPVI)/Fc receptor gamma (FcRgamma)-chain-dependent platelet activation through its interaction with Syk
- These results demonstrate that Syk participates in CXCL12-induced cell polarization, which occurs in concert with cell adhesion mediated by beta1 integrin.
- The SYK is present in the majority of mediastinal B cell lymphomas.
- Novel role for Syk in the maintenance of a bipolar phenotype by regulating lamellipodium formation, which is a critical prerequisite for site-directed migration of leukocytes.
- HS1 Tyr phosphorylation catalyzed by Syk and Lyn plays a crucial role in the translocation of the protein to the membrane and is involved in the cytoskeleton rearrangement triggered by thrombin in human platelets
- Syk-transfected cells formed significantly fewer metastatic tumor lesions than control cells. Syk is novel regulator of metastatic behavior of melanoma cells.
- Dectin-1 activates Syk tyrosine kinase in macrophages for reactive oxygen production
- Data reveal a complex process controlling the association and catalytic activity of protein tyrosine kinases syk and lyn with the human erythrocyte membrane.
- CD21 activation triggered Cbl tyrosine phosphorylation, which interacts with SH2 domains of p85 subunit, SH2 domains of Crk-L and with tyrosine phosphorylated Syk kinase. CD21 activation triggers dissociation of Cbl-Vav complex.
- Shiga toxin (Stx)was found to activate Syk and induce rapid tyrosine phosphorylation of several proteins, one protein being clathrin heavy chain.
- Syk plays an indispensable role in complement-mediated phagocytosis by regulating both actin dynamics and the RhoA activation pathway, and these functions of Syk lead to phagosome formation and pathogen engulfment.
- the cross-talk between Syk and Lck regulates hypoxia/reoxygenation-induced breast cancer progression
- Taken together, these findings indicate that C3bi targets the phagocytic cargo, and engagement or diversion of the Syk route determines the phagocyte response.
- Overview discusses the role of Syk that is essential to complement-mediated phagocytosis.
- identify novel regulatory mechanisms of leukocyte rolling on selectins with a strong dependency on lipid raft integrity and Syk activity
- overexpression of PTPROt inhibited BCR-triggered SYK tyrosyl phosphorylation, activation of the associated adaptor proteins SHC and BLNK, and downstream signaling events, and inhibition lymphoma cell proliferation and inducion of lymphoma cell apoptosis
- direct interactions between native Syk and PI3K proteins are differentially regulated during FcgammaR phagocytosis and endocytosis.
- The different patterns of aberrant methylation of the SYK gene in the various histopathological cancer types of the urinary bladder point to a role in tumor cell differentiation.
- TNF-induced activation of pro-inflammatory signaling in EC leading to enhanced expression of iNOS and NO production was dependent on Syk.
- Downstream of intercellular adhesion molecule-1 Syk is necessary for the activation of p38 MAP kinase following human rhinovirus infection in airway epithelium.
- Syk is critical for lamellipodia formation on a range of immobilized proteins but that this can be overcome by addition of thrombin. Further, we reveal a novel role for GPVI in supporting thrombin-induced activation, independent of Syk and Src kinases
- Data suggest that Syk is a protooncogene involved in the transformation of lymphocytes, thus making Syk a potential target for the treatment of leukemia.
- Syk tyrosine kinase is downregulated by methylation and functions as a tumor suppressor in malignant melanoma.
- study shows tyrosine kinase Syk constitutively associates with TLR4 in THP-1 cells; findings implicate Syk as a novel modulator of LPS-mediated TLR4 response in monocytic cells & shed insight on the kinetics of early complex formation upon LPS engagement
- These data demonstrate a role for Anaplasma phagocytophilum-mediated ROCK1 phosphorylation in infection induced by PSGL-1 and mediated by Syk.
- These data reveal CEACAM3 as a specific innate immune receptor that mediates the opsonin-independent clearance of CEACAM-binding bacteria via Syk, a molecular trigger for functional immunoreceptor responses of both the adaptive and innate immune systems.
- About 18% of Indian subjects studied showed non histamine-releaser phenotype & also had reduced Lyn & Syk kinase expression. Non-releasers have also shown less potent isoform of IL-3/P8, which is suspected to be responsible for non-releaser phenotype
- PF4-stimulated immediate monocyte functions (oxygen radical formation) are regulated by p38 MAPK, Syk, and PI3K, whereas delayed functions (survival and cytokine expression) are controlled by Erk and JNK.
- Syk is required to link phosphorylated SLP-65 to Ca(2+) mobilization.
- the lung mast cells in these experiemnts were defective in their IgE-mediated signaling, most liked related to a deficienty in Syk protein.
- review focuses on the non-receptor tyrosine kinase Syk as an important downstream signaling component of beta2 integrins (CD11/CD18) that is required for the control of different PMN functions including adhesion, migration and phagocytosis.
- SYK-dependent tonic B-cell receptor signaling s an important and potentially targetable survival pathway in some diffuse larg B-cell lymphomas.
- Plasmacytoid dendritic cells express a signalosome consisting of Lyn, Syk, Btk, Slp65 (Blnk) and PLCgamma2. Triggering CD303 leads to tyrosine phosphorylation of Syk, Slp65, PLCgamma2 & cytoskeletal proteins.
- residues outside the catalytic domain of Syk suppress kinase activity
- Syk is an important mediator of human rhinovirus (HRV) endocytosis and HRV-induced PI3K activation.
- TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk
- Syk kinase deficient basophils from patients with Chronic Idiopathic Urticaria exhibit a spectrum of releasability.
- Syk signals downstream of PKC-delta to mediate thrombin induced ICAM-1 expression in endothelial cells by increasing transcriptional capacity of NF-kappaB via a mechanism that relies on tyrosine phosphorylation of RelA/p65
- Overexpression of Syk tyrosine kinase is associated with peripheral T-cell lymphomas
- these results demonstrated that NS5A interacts with Syk resulting in negative regulation of its kinase activity.
- Anaplasma phagocytophilum entry does not depend on Syk.
- analysis of dephosphorylation of the FcRgamma immunoreceptor tyrosine-based activation motif tyrosines with dissimilar potential for activating Syk
- The role of the tyrosine kinase Syk in shear-induced human platelet signaling was studied.
- Syk functions as an "OR-gate" type of molecular switch and is more readily activated by autophosphorylation than Zap-70
- Selective tyrosine phosphorylation of oxidized band 3 by Syk may play a role in the recruitment of oxidized band 3 in large membrane aggregates that show a high affinity to NAbs, leading to RBC removal from the circulation.
- while Vav-1 and LAT preferentially bound to Syk, phospholipase C-gamma1 bound to both Syk and ZAP-70
- dectin-1 activates two independent signaling pathways, one through Syk and one through Raf-1, to induce immune responses.
- The overexpression of TRIP sensitizes cells to TNF-induced apoptosis, an effect that can be reversed by the coexpression of Syk.