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Validated All-in-One™ qPCR Primer for SULT1A3(NM_177552.4) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Exons of this gene overlap with exons of a gene that encodes a protein containing GIY-YIG domains (GIYD1).
Gene References into function
- M-PST is involved in protective and detoxification mechanisms that may operate in neurodegenerative processes in the brain
- structure-function relationships in the stereospecific and manganese-dependent 3,4-dihydroxyphenylalanine/tyrosine-sulfating activity of human monoamine-form phenol sulfotransferase, SULT1A3
- the differential substrate specificity of the two enzymes M-PST and P-PST for the thirteen drug compounds tested
- Eight single nucleotide polymorphisms were observed in African American[AA] and five in Caucasian-American subjects, including one (Lys234Asn) that was observed only in AA subjects with an allele frequency of 4.2%
- For SULT1A3, substrate inhibition is found for dopamine but not with pNP. Based on modeling and kinetic studies, it is proposed that substrate inhibition by dopamine in SULT1A3 is caused by binding of two dopamine molecules in the active site.
- 2 SULT1A3 genes were present on chromosome 16 in all DNA samples studied.
- X-ray crystallographic analysis of SULT1A3 complexed with dopamine and 3'-phosphoadenosine 5'-phosphate
- Of the 11 human cytosol sulfotransferase enzymes tested, only SULT1A3 displayed sulfating activity toward nitrotyrosine. The pH-dependence and kinetic constants of SULT1A3 with nitrotyrosine or dopamine as substrate were determined.
- data from this study shows that the human SULT1A3 gene is inducible by glucocorticoids through a glucocorticoid receptor-mediated mechanism and the glucocorticoid response element at position (-1211 to -1193) is necessary for this induction.