|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for SNAP25(NM_001322902.2) Search again
Product ID:
HQP161091
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CMS18, RIC-4, RIC4, SEC9, SNAP, SNAP-25, SUP, bA416N4.2, dJ1068F16.2
Gene Description:
synaptosome associated protein 25
Target Gene Accession:
NM_001322902.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two.
Gene References into function
- Identified a novel microsatellite repeat in SNAP-25 and case-control analyses suggest there may be a role of this polymorphism in ADHD.
- SNAP-25 traffics to the plasma membrane by a syntaxin-independent mechanism.
- This protein modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.
- Synaptosome-associated protein of 25 kDa (SNAP25) has been identified as a new kinesin heavy chain (uKHC)-interacting protein.
- elevated mRNA levels of SNAP-25 in adult Down Syndrome brain.
- trend consistent with biased transmission of the TC haplotype of SNAP-25 in all transmissions and detected a significant distortion (P=0.027) when paternal transmissions were evaluated for attention deficit disorder with hyperactivity
- In the hippocampus, the level of SNAP-25 protein is significantly less in the schizophrenic group compared to control or bipolar groups.
- SNAP-25 in cerebrospinal fluid is elevated in schizophrenia suggesting that synaptic pathology may be linked with the pathophysiology of schizophrenia.
- the syntaxin/SNAP-25 dimer binding to synaptotagmins I and II is mediated by an evolutionarily conserved motif
- Association of SNAP-25 with ADHD is largely due to transmission of alleles from paternal chromosomes.
- SNAP-25 is required for the activation and maintenance of store-mediated calcium entry in platelets
- first structure of a CNT endopeptidase in complex with its target SNARE at a resolution of 2.1 A: botulinum neurotoxin serotype A (BoNT/A) protease bound to human SNAP-25
- However, effects of diazoxide on SNAP-25 protein were nullified by proteasome inhibitors (ALLN, MG-132, and epoxomicin) but not by lysosomal inhibition (NH(4)Cl).
- Quantitative analysis of the dimensions of hyperactivity/impulsivity and inattention in the Toronto sample found that both behavioral traits were associated with SNAP25.
- Variation in single-nucleotide polymorphism is associated with cognitive ability in a Dutch twin study.
- The fact that this protein undergoes Ca2+-induced conformational changes and interacts with SNAP-25 raise the possibility that secretagogin may link Ca2+ signalling to exocytotic processes.
- This study provides significant evidence for assoiatetion single nucleude polymorphism in Korean Attention Deficit Hyperactivity Disorder.
- evidence supporting the association of previously implicated SNPs (rs3746544, rs1051312) of SNAP-25 to ADHD. Co-morbidity with major depressive disorder may enhance detection of the association between SNAP-25 and ADHD.
- We report a loss of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein, synaptosome-associated protein 25 (SNAP 25) in HD brains of grades I-IV.
- Two new variants in intron 1 show association with variation in IQ phenotypes in Dutch twins.
- The heterogeneous distribution of SNAP-25 may have important implications not only in relation to the function of the protein as a SNARE
- In this German ADHD sample no preferential transmission of either variant could be observed.
- The expression of the SNARE protein SNAP-25 and its cellular homologue SNAP-23, as well as syntaxin1 and VAMP (vesicle-associated membrane protein) in samples of normal parathyroid tissue, chief cell adenoma, and parathyroid carcinoma, was examined.
- SNARE complex-related genes STX1A, VAMP2 and SNAP25 do not play a major role in susceptibility to schizophrenia in the Japanese population
- structural and functional implications of linked SNARE motifs in SNAP25
- Results suggest that SNAP-25 is up-regulated and implicated in neuritogenesis in human neuroblastoma SH-SY5Y cells treated with the neuropeptide VIP.
- Expressed in prolactin-producing pituitary adenomas; may play an important role in prolactin release.
- SNAP-25 substrate peptide (residues 180-183) binds to but bypasses cleavage by catalytically active Clostridium botulinum neurotoxin E
- SNAP-25 genotype may modulate synaptic plasticity and neurogenesis in the left hippocampus
- Direct interaction of otoferlin with syntaxin 1A, SNAP-25, and the L-type voltage-gated calcium channel Cav1.3.