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Validated All-in-One™ qPCR Primer for HLTF(NM_139048.3) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein. [provided by RefSeq].
Gene References into function
- SMARCA3 is the human gene for RUSH transcription factors (U66564, U66565; Mol Endocrinol, 1996, 10:1335-1349). A binding partner has been cloned and characterized (AF236061; JBC, 2001, 276:3641-3649).
- HLTF/SMARCA3, a member of SWI/SNF family, is a common target for methylation and epigenetic gene silencing in colon cancer and a candidate colon cancer suppressor gene.
- These results suggest that HLTF promoter hypermethylation is frequently demonstrated in human gastric cancer, and inactivation of HLTF or the chromatin-remodeling complex may play a crucial role in gastric carcinogenesis.
- Acetylation of histones H3 and H4 in the 5' CpG island of the HLTF gene were inversely associated with DNA methylation status.
- Methylation helicase-like transcription factor is associated with advanced esophageal squamous cell carcinoma
- HLTF activation was recently linked to the initial steps of carcinogenesis in an experimental model of estrogen-induced kidney tumor. [REVIEW]
- HLTF physically interacts with the Rad6-Rad18 and Mms2-Ubc13 ubiquitin-conjugating enzyme complexes and promotes the Lys-63-linked polyubiquitination of proliferating cell nuclear antigen at its Lys-164 residue.
- Splice arrays and RT-PCR showed that although most splice variants in RUSH and ATP11B are conserved in human and rabbit, the RFBP isoform is specific to rabbit.
- HLTF and SHPRH are functional homologues of yeast Rad5 that cooperatively mediate PCNA polyubiquitination and maintain genomic stability.
- There is an association between the presence of helicase-like transcription factor and neoplastic progression of hypopharyngeal and laryngeal squamous cell carcinomas.