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Validated All-in-One™ qPCR Primer for SLC16A1(NM_001166496.2) Search again
Product ID:
HQP161000
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HHF7, MCT, MCT1, MCT1D
Gene Description:
solute carrier family 16 member 1
Target Gene Accession:
NM_001166496.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The SLC16A1 gene encodes a monocarboxylate transporter (MCT1) that mediates the movement of lactate and pyruvate across cell membranes Import and export of these substrates by tissues such as erythrocytes, muscle, intestine, and kidney are ascribed largely to the action of a proton-coupled MCT (Garcia et al., 1994 [PubMed 8124722]).[supplied by OMIM].
Gene References into function
- substrate-induced regulation of human colonic MCT1. The basis of this regulation is a butyrate-induced increase in mRNA abundance, resulting from the dual control of gene transcription and stability of the transcript
- the structural organization of the human MCT1 gene and 5'-flanking region which contains potential binding sites for a variety of transcription factors with known association with butyrate's action in the colon
- Carcinoma samples displaying reduced levels of MCT1 were found to express the high affinity glucose transporter, GLUT1, suggesting that there is a switch from butyrate to glucose as an energy source in colonic epithelia during transition to malignancy
- MCT1 and NHE1 genes play important regulation roles in proliferation and growth of tumor cells, probably by affecting pHi.
- MCT1 is involved in cellular transportation of butyrate, which induces cellular differentiation. Down-regulation is suggested to be involved in human breast cancers.
- MCT mediates biotin uptake in human lymphoid cells.
- MCT1 content in skeletal muscle in Type 2 diabetes is lower compared with healthy men. Strength training increases MCT1 content in healthy men and in Type 2, thus normalizing the content in Type 2.
- studies demonstrate that the opposing plasma membranes of human syncytiotrophoblast are polarized with respect to both monocarboxylate transporter MCT1 and MCT4 activity and expression
- These results show the importance of MCT1 to the ability of butyrate to induce cell-cycle arrest and differentiation, and suggest fundamental differences in the mechanisms by which butyrate modulates specific aspects of cell function.
- MCT1 is functionally active and is the only MCT isoform involved in the apical uptake of monocarboxylates by retinal pigmented epithelial ARPE-19 cells
- Distinct MCT isoforms may be involved in short-chain fatty acid transport across the apical or basolateral membranes in polarized colonic epithelial cells.
- studies demonstrate inhibition of MCT1-mediated butyrate uptake in Caco-2 cells in response to enteropathogenic Escherichia coli infection
- The inhibition of MCT1 during T lymphocyte activation results in selective and profound inhibition of the extremely rapid phase of T cell division essential for an effective immune response.
- Monocarboxylate transporter MCT1 is strongly expressed by glial cells often associated with blood vessels that were identified as astrocytes. (Monocarboxylate transporter MCT1)
- this study shows conflicting adaptations in MCT1 and MCT4 protein and mRNA levels following training, which may indicate post-transcriptional regulation of MCT expression in human muscle.
- demonstrated greater activity of the RBC monocarboxylate cotransporter MCT-1, lower RBC deformability and impaired hematological indices in sickle cell trait (SCT) carriers compared to control subjects
- Targeting the Map kinase signal transduction cascademay provide a potential therapeutic approach in lymphomas and related malignancies that exhibit high levels of the MCT-1 protein.
- A single bout of high-intensity exercise decreased both MCT relative abundance (MCT1 and MCT4) in membrane preparations.
- DL-2-Hydroxy-(4-methylthio)butanoic acid is transported into the colonic cancer cell line cell membrane by a transport mechanissm involving MCT1.
- These studies show that promoter-activating mutations in exercise-induced hyperinsulinism induce SLC16A1 expression in beta cells, permitting pyruvate uptake and pyruvate-stimulated insulin release despite ensuing hypoglycemia.
- In obesity, MCT1 expression appears linked both to changes in oxidative parameters and to changes in visceral adipose tissue content.
- Expression of MCT1 and MCT4 showed a significant gain in plasma membranes of colorectal neoplasms.
- the effective movement of H(+) into the bulk cytosol is increased by CAII, thus slowing the dissipation of the H(+) gradient across the cell membrane, which drives MCT1 activity
- Report effects of high-intensity training on muscle MCT1/4 and postexercise recovery of muscle lactate and hydrogen ions in women.
- PKC-zeta dependent stimulation of the human MCT1 promoter involves transcription factor AP2.
- MCT1 was found to be expressed by an array of primary human tumors, we suggest that MCT1 inhibition has clinical antitumor potential.