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Validated All-in-One™ qPCR Primer for SELPLG(NM_001206609.2) Search again
Product ID:
HQP160684
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD162, CLA, PSGL-1, PSGL1
Gene Description:
selectin P ligand
Target Gene Accession:
NM_001206609.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
SELPLG is the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. The organization of the SELPG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters.
Gene References into function
- Comparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters
- Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1, E-selectin for adhesive interactions with human vascular endothelium under flow conditions
- G-CSF down regulates PSGL-1 expression on the surface of neutrophils in humans
- Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin.
- Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for herpes simplex virus type 2(cutaneous lymphocyte-associated antigen)
- Binding of two anti-human (KPL1 and PL1) and two anti-mouse (4RA10 and 2PH1) PSGL-1 mAbs to synthetic peptides of N-terminus of human and mouse PSGL-1 was found to be independent of tyrosine sulfation.
- The epitope recognized by the M-DC8 MAb is 6-sulfo LacNAc, a novel carbohydrate modification of the P selectin glycoprotein ligand 1 (PSGL-1)
- increased PSGL-1 expression on granulocytes from allergic-asthmatic subjects resulted in increased leukocyte recruitment on P-selectin under flow conditions
- PSGL-1 engagement induces tyrosine phosphorylation of Syk and SRE-dependent transcriptional activity.
- Inhibitors of glycosylation alter HECA-452 expression on human cutaneous lymphocyte-associated antigen-positive T-cells and prevent T-cell tethering and rolling on selectins under shear stress.
- Stimulation of eosinophils with eotaxin-2 converts PSGL-1-P-selectin-dependent stationary adhesion to CD18-mediated shear-resistant stable attachment. Blocking eosinophil-platelet interactions may combat thrombotic disorders in hypereosinophilia.
- Anti-P-selectin glycoprotein ligand-1 (PSGL-1) antibodies dramatically block the recruitment of CD8+ cells in brain vessels of patients with multiple sclerosis
- L-selectin binds with high affinity to the N-terminal region of PSGL-1 through cooperative interactions with three sulfated tyrosine residues and an appropriately positioned C2-O-sLex O-glycan.
- atomic force microscopy and flow-chamber experiments show that increasing force first prolonged and then shortened the lifetimes of P-selectin complexes with P-selectin glycoprotein ligand-1
- Anaplasma phagocytophilum infected neutrophils showed reduced expression of P-selectin glycoprotein ligand 1 (PSGL-1, CD162) and L-selectin (CD62L)
- results demonstrate that the PSGL-1 variable number of tandem repeat polymorphism is not a genetic risk factor for coronary heart disease
- determination that PSGL-1 is an additional substrate for BACE1
- PSGL1 is not essential for E-selection promotion of growth inhibition and apoptosis of human and murine hematopoietic progenitor cells
- PSGL-1, by mediating monocyte-platelet interactions, plays a major role in secondary monocyte tethering.
- platelet-monocyte complex formation is mostly dependent on PSGL-1
- PSGL-1 and VLA-4 play an important role for leukocyte recruitment during intestinal inflammation. Therapeutic strategies designed to disrupt interactions mediated by PSGL-1 and/or VLA-4 may prove beneficial in treatment of chronic colitis.
- core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 have roles in rolling on P-selectin
- platelet P-selectin and microparticle PSGL-1 have roles in thrombus formation [review]
- binding of E-selectin to PMNs in suspension also elicited coclustering of L-selectin and PSGL-1 that was signaled via mitogen-activated protein kinase.
- The interaction of PSGL-1 with P-selectin (CD62P) mediates tethering, rolling, and weak adhesion of leukocytes
- PSGL-1 interacts with CCL27 (CTACK/ILC/ESkine), a skin-associated chemokine that attracts skin-homing T lymphocytes
- CLA and E-selectin are bound by T cells and have roles in skin inflammation [cutaneous lymphocyte-associated antigen, also called BE-2]
- PG-M/versican binds to P-selectin glycoprotein ligand-1 and has a role in mediating leukocyte aggregation
- Induced expression of cutaneous lymphocyte antigen on helper T cells determined a striking increase of rolling efficiency in inflamed brain venules.
- immune response to alpha-streptococci may enhance expression on tonsillar T-cells in pustulosis palmaris et plantaris
- A differential functional impact of N-glycosylation on C2GnT-1 and FucT-VII and disclose that a strongly reduced FucT-VII activity retains the ability to fucosylate PSGL-1 on the core2-based binding site(s) for the three selectins.
- CLA is expressed in circulating mononuclear cells of patients with psoriasis
- In conclusion, the C allele of the VNTR polymorphism in PSGL-1 is likely to be associated with PP-MS.
- biophysical analysis of PSGL-1/P-selectin neutrophil adhesion
- CD43 is a T-cell E-selectin ligand distinct from PSGL-1 which expands the role of CD43 in the regulation of T-cell trafficking.
- Plasmacytoid dendritic cells are particularly potent inducers of cutaneous lymphocyte-associated antigen on HSV-reactive memeory CD4 T cells
- 98% of CLA(+) effector memory T cells are resident in normal skin under resting conditions
- rPSGL-Ig delays the aggregation process and increases the anti-aggregatory potency of GPIIb-IIIa antagonist
- More than 50% of circulating CD4+CD25(high) regulatory T cells from both patients as well as healthy controls expressed cutaneous lymphocyte-associated antigen.
- No significant association was found between PSGL-1 VNTR polymorphisms and in-stent restenosis. However, in patients with a family history of early CAD presence of PSGL-1 AB genotype might increase the risk of in-stent restenosis.
- ECs express functional PSGL-1 which mediates tethering and firm adhesion of monocytes and platelets to inflamed endothelium.
- These data demonstrate a role for Anaplasma phagocytophilum-mediated ROCK1 phosphorylation in infection induced by PSGL-1 and mediated by Syk.
- The association of PSGL-1 with lipid microdomains is essential for its redistribution induced by IL-8 stimulation and that the redistribution modulates neutrophil functions mediated by interactions with P-selectin.
- Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes may have roles in coronary heart disease and ischemic stroke
- activation of EphB4 enhances proangiogenic capacity through induction of PSGL-1 expression and adhesion to E selectin and P selectin
- It is suggested that the VNTR polymorphism of PSGL-1 is a significant determinant of thrombotic predisposition in patients with APS.
- ADAM28s promotes PSGL-1/P-selectin-mediated leukocyte rolling adhesion to endothelial cells and subsequent infiltration into tissue spaces through interaction with PSGL-1
- A new method for determining receptor-ligand association/dissociation events across the interface of two surfaces (two-dimensional binding) by monitoring abrupt decrease/resumption in thermal fluctuations of a biomembrane force probe.
- These findings suggest that 1,25D(3) can selectively downregulate CLA expression without influencing lymphocyte migration patterns to other tissues.
- regulation of O-glycosylation controls sLe(x) expression, and also suggest that O-glycans may have a function in dendritic cells migration
- a lectin domain residue in L-selectin has a role in binding to P-selectin glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis x
- P-selectin-PSGL-1-induces TF and IL8 expression through Lyn phosphorylation, and part of the inhibitory effect of IL10 depends on reduced phosphorylation
- Report complete downmodulation of P-selectin glycoprotein ligand in monocytes undergoing apoptosis.
- Results suggest that the generation of C5a induced by hemodialysis membranes is responsible for the clustered redistribution of PSGL-1 in neutrophils leading to the increase in the platelet-neutrophil microaggregate formation.
- These data fervently hint that specific recognition of the PSGL-1 N-terminus is crucial for optimal Anaplasma phagocytophilum AnkA delivery.
- Our data suggest that in the absence of overt activation, PSGL-1 (P selectin ligand 1-P-selectin-dependent platelet binding to monocytes represents a normal physiological process with little impact on the potential of monocytes to cause vascular injury
- cooperation of the alpha(M)beta(2)/GPIbalpha and to PSGL-1/P-selectin systems regulates the prothrombotic properties of PMN-derived microparticles and MP-induced platelet activation
- PSGL-1 level was also higher on human CD14+CD16- monocytes than on CD14-CD16+ monocytes.
- the role of PSLG1 decamers is to extend PSGL-1 N terminus far above the cell surface to support and stabilize leukocyte rolling on L- or P-selectin
- HECA-452 could be of prognostic relevance in the early stage of mycosis fungoides