|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for CCL5(NM_001278736.2) Search again
Product ID:
HQP160613
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
Gene Description:
C-C motif chemokine ligand 5
Target Gene Accession:
NM_001278736.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes.
Gene References into function
- Differential production of RANTES and MCP-1 in synovial fluid from the inflamed human knee.
- RANTES levels in blood, quantities released from platelets ex vivo, and quantities released from SFFLRN stimulated platelets ex vivo were compared for preeclamptic and normal pregnancies.
- synthesis was detected in human Leydig cells exposed to the Sendai virus, but not in human total germ cells
- The prototypic inflammatory chemokine RANTES activates a defined transcriptional profile in fresh human monocytes consisting of stimulation of at least 42 genes of 5600 examined.
- We determined that human serum contains a molecule that suppresses RANTES (CCL5) binding to endothelial cells, PBMC and CHO cells.
- A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes.
- modulating influence on HIV/AIDS by interacting with variants
- in infants with respiratory syncytial virus bronchiolitis, the proportion of RANTES relative to IL-8 was significantly increased
- CCR5 protein has a role as a HIV-1 receptor favoring the recruitment of fusiogenic proteins and the formation of a fusion pore.
- TNF-alpha potently induced RANTES secretion, but IL-17 dose-dependently inhibited the TNF-alpha-induced RANTES secretion in human colonic subepithelial myofibroblasts. This was also observed at the mRNA level.
- functional AhR are present in endometrial and endometriotic stromal cells and that TCDD up-regulates the expression of RANTES, providing a possible mechanistic link between dioxin exposure and chemokine expression in endometriosis.
- Expression of RANTES is induced by stimulation of monocytic cells through Fc gamma receptors and involves activation of CCAAT enhancer-binding protein beta sites.
- results demonstrate that both CCR1 and CCR4 are functional receptors on human mast cells with capacity to mediate migration towards CCL5
- role of viral accessory protein Vpr and Nef in RANTES/CCL5 expression
- role of IL-12 and IFN-gamma on inducing inflammatory chemokine (CCL5) secretion and down-regulating CCR5 expression in human T cells
- The RANTES(9-68)-heparin interaction has been characterized by a complex binding model that involves heparin-induced dimerization of the chemokine through a mechanism of positive cooperativity.
- RANTES expression is regulated by CFTR in airway epithelial cells
- Associations of RANTES polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Hepatitis C virus-seropositive whites with the RANTES -403-A allele were less likely to have severe hepatic inflammation.
- RANTES promoter -28G genotype and CCR5 promoter 59029A genotype may be independent risk factors for diabetic nephropathy in patients with type 2 diabetes and may have an additive effect on nephropathy.
- mast cells may regulate lymphocytic infiltration in basal cell carcinoma through the production of RANTES
- TNF-alpha-induced expression of RANTES plays important roles in cell-mediated liver injury in alcoholic liver diseases.
- RANTES is not upregulated by leptin in human monocytic cells
- Efficient leukocyte arrest in flow but not transmigration may thus require the presentation of RANTES oligomers to bridge surface-bound RANTES and CCR1.
- The RANTES promoter polymorphism is a genetic risk factor for near-fatal asthma in Chinese children.
- case-control study was performed to evaluate the role of -403G --> A and -28C --> G as susceptibility factors for HIV-1 infection in the Spanish population; data consistent with lack of association between these SNPs and HIV-1 infection in this populatio
- Data suggest that in oral lichen planus, the presence of CCL5 and CXCL10 in the cytolytic granules of tissue-infiltrating CD8(+)T cells expressing CCR5 and CXCR3 reveals a potential self-recruiting mechanism involving activated effector cytotoxic T cells
- Data are consistent with the lack of association between RANTES polymorphisms and endometriosis, but do not exclude a possible role of other variants within the RANTES gene in this pathology.
- A putative signal transduction pathway leading to RANTES production from fibroblasts when the DR molecules were ligated was detected
- dichotomous effects of RANTES on HIV-1 entry at the moment of infection, and on production and spread of virus progeny in primary macrophages
- Two single nucleotide polymorphisms in RANTES promoter region and intron I were found to be associated with the genetic susceptibility to HIV-1 infection among Chinese and the In1.1C allele displayed a stronger association with HIV-1 infection in males.
- RANTES expression and production increase in nasal mucosa (septal and turbinate portions) of allergic patients compared to the same mucosa in non-allergic patients
- peritoneal macrophage stimulation of RANTES production by endometrium stromal cells could lead to a self-propagating recruitment of inflammatory cells that contribute to the development and progression of endometriotic lesions.
- The study results indicated that the -403 and -28 alleles in the RANTES promoter region belong to the predictor gene set for allergic rhinitis and could be used in genomic analysis.
- prior or simultaneous treatment of HEp-2 cells with recombinant human CCL5 provides dose-dependent inhibition of infection with RSV.
- TWEAK acts on human keratinocytes as an inducer of RANTES via Fn14.
- Our results demonstrate that IFNbeta plays a positive regulatory role in the expression of RANTES/CCL5 in human astrocytes through several distinct mechanisms
- CCL% expression frequent in ATL and HTLV-I-infected cell lines; aberrant expression may impact pathophysiology of HTLV-I-associated diseases
- SNP -403G may be associated with increased susceptibility to HIV infection, while -28G may be associated with advanced disease
- A strong upregulation of MCP-1 and RANTES was observed in all the cases, mainly in tubular cells, and there was a strong correlation between the expression of these chemokines and NF-kappaB activation in the same cells.
- RANTES haplotypes might contribute to polygenic interaction between hepatitis C virus and host immune system and could help to risk stratify patients prior to antiviral therapy.
- Stimulation of monocytes with supernatants of activated platelets triggered arrest involving RANTES and PF4.
- Data show that RANTES -28 promoter, but not monocyte chemoattractant protein-1 regulatory polymorphisms are associated with systemic lupus erythematosus in Chinese children.
- There is a significant but complex association of the RANTES gene with multiple sclerosis
- Increased gene expression and protein production in synovial fibroblasts, in response to interleukin-1beta, may play an important role in recruitment of inflammatory cells into synovium and progression of synovitis in temporomandibular joint disorders
- secretion induced by binding of HCV E2 to CD81 with subsequent intracellular accumulation of CCR5.
- However, In the presence of TNF-alpha, melatonin promoted RANTES melatonin, respectively) expression in a dose dependent manner in A549 cells).
- produced by neonatal natural killer cells and contributes to suppession of HIV replication
- Role in the development of bronchiolitis associated with influenza and RSV infections in infants and children.
- activation of the NF-kappaB pathway by LMP-1 is required for the activation of CCL5 expression
- RANTES, MIP-1beta and IL-18 are expressed in LGL leukemia
- Even though H. pylori itself induces expression of RANTES, at the transcriptional level, genetic variations leading to higher transcriptional activity do not modify the degree of inflammation.
- PI3K-Akt activation and subsequent inhibitory phosphorylation of GSK3beta are required for HGF-induced suppression of RANTES in human kidney proximal tubule epithelial cells
- Treatment to enhance RANTES expression may assist in delaying the progression of AIDS by decreasing the initial viral load.
- RANTES appears to play an important role in mobilization of eosinophils into the local inflamed tissue.
- Sphingosine 1-phosphate attenuates cell migration by inhibiting a Rac1-dependent signaling pathway and decreases RANTES production by stimulating a Galpha(q)-dependent mechanism both possibly through the S1P(2) receptors
- RANTES itself could inhibit the replication of SARS-CoV in THP-1 cells when it was added into the culture before or at the same time with the virus; No inhibition effect was shown when RANTES were added into the culture after SARS-CoV infected the cells
- Platelet microparticles may serve as transcellular delivery system for RANTES, triggering monocyte arrest; introducing a novel mechanism for platelet-dependent monocyte recruitment in inflammation and atherosclerosis.
- Patients carrying the RANTES -403A or In1.1C allele had a significantly higher all-cause mortality risk, mainly due to cardiac events. The other SNPs studied showed no effect on survival.
- Polymorphism in the promoter region of RANTES gene is associated with the susceptibility to rheumatoid arthritis in the Chinese population
- Cigarette smoke may directly cause the release of IL-8 from HASMC, an effect enhanced by TNF-alpha which is overexpressed in COPD
- It is reported that 2 polymorphisms in the RANTES promoter do not correlate with SLE individually; interaction of the polymorphisms probably exerts a risk effect against SLE; and polymorphism at the 403 locus is probably related with renal damage.
- No differences in mRNA levels between atopic dermatitis patienets and controls with the -401A genotype
- expression of CCL5 & CCR5 in prostate cancer (PCa) cell lines, primary cultures, & tissues; study suggests CCL5 may function as an autocrine factor that binds to PCa cell-surface receptors, activating cellular responses important in cancer progression
- The mucosal inflammatory response to H. pylori infection involves different signaling pathways for activation of the RANTES promoter, with both OipA and the cag PAI being required for full activation of the RANTES promoter
- Neither the biotinylated ovalbumin nor the unlabeled HSP70 cross-linked with a biotinylated protein stimulated RANTES production which was induced by biotinylated HSP70 itself.
- role of inflammation also in the early stages of atherogenesis possibly involving monocyte-derived RANTES as an important mediator
- In heart transplantation, outcomes of early and late rejection episodes may be influenced by genetic variant interactions such as "CX3CR1 249I*CCR5 No-E" and "CCR5 E*RANTES -403A."
- HIV-1-infected long-term nonprogressors of more than 16 years is not associated with SNPs in the RANTES gene promoter in white Spanish HIV-1-infected subjects.
- Higher amounts of MIP-1alpha, MIP-1beta, and RANTES were detected in plasma of HIV-1-positive individuals, particularly those with concomitant pulmonary tuberculosis, although the increase was not found to be statistically significant.
- functional mutation at -403 in the promoter does not seem to influence acute rejection development and allograft survival in liver recipients
- the production of RANTES was enhanced by the interaction with chondrocyte-T cel and that chondrocyte-T cell contact was possible in vivo.
- Data show that RANTES is overexpressed in rheumatoid arthritis synovial fluid and is a potential mediator influencing intensity and composition of cellular infiltration in joints affected with inflammatory arthritis.
- High levels of CCL5 are present in synovial fluid of children with juvenile idiopathic arthritis. Present in synovial biopsies, in particular on endothelium of small and medium sized vessels.
- mast cell beta-tryptase selectively cleaves asthmatic airway smooth muscle (ASM)-derived eotaxin and RANTES and abrogates their chemotactic activities, thus providing an explanation for the eosinophil paucity in asthmatic ASM bundles
- elevated TGF-beta1 in rheumatoid synovial tissue may suppress joint inflammation by inhibiting RANTES secretion from synovial fibroblasts, thus blocking the infiltration of immune cells
- The platelet-derived chemokine RANTES exhibited particular changes after stem cell transplantation (SCT); results suggest that RANTES plays a role in GVDH after allo-SCT
- Studying 95 African samples from Cameroon, there was found a naturally occurring variant of CCL5/RANTES containing a missense mutation located in the first amino acid of the secreted form (S24F).
- CCL5-GAG binding and CCL5 aggregation are important for CCL5 activity in T cells, specifically in the context of CCR5-mediated apoptosis
- RANTES SNPs are significantly associated with RANTES serum concentration and development of type 1 diabetes.
- 15d-PGJ2 significantly decreased CD40 and RANTES expression in HK-2 cells, which were partially mediated by PPAR-gamma-dependent pathways.
- The effect of RANTES polymorphisms on human immunodeficiency virus type 1 (HIV-1) disease progression in an urban population of Uganda, which protection from death.
- Data suggest that RANTES and IL-10 are secreted from mesenteric adipose tissue and creeping fat, and that the elevated RANTES secretion from creeping fat in Crohn's disease is caused by steroid treatment.
- C-reactive protein (CRP) activates the MAP-K pathway of renal distal tubular cells (DTC). CRP upregulated RANTES expression of DTC in a significant and dose-dependent manner.
- Women with endometriosis-associated infertility have a poor IVF outcome.
- findings show that CCL3, CCL4 and CCL5 bind on the Leishmania promastigotes
- RANTES down-regulates TLR4 ligation-induced IL-6 and TNF-alpha secretion by enhancing IL-10 production in PB monocytes.
- Thrombocytopenia may be a source of reduced RANTES which may contribute, at least in part, to suppression of erythropoiesis in children with malarial anemia.
- Adenylyl cyclase activator forskolin reproduced the effects of ISO. Isoproterenol was found to inhibit the release of RANTES from the human bronchial epithelial cells
- under shear stress, T cells encountering apically presented CXCL12 were primed to undergo robust LFA-1-dependent transendothelial migration toward subendothelial CCL5
- KLF13 is a key regulator of late RANTES expression in T lymphocytes
- Through RANTES production in response to specific allergen, mononuclear cells play a crucial role in asthma pathogenesis, particularly in eosinophil and T lymphocyte recruitment into the inflamed focus of asthma.
- Progesterone significantly increased intracellular RANTES expression in CD4+ and CD8+ endometrial T cells
- RANTES is regulated by extracellular parts of the CCR5 receptor
- The increased expressions of RANTES and CCR5 mRNAs in renal transplant recipients with hyperlipidemia might be involved in chronic allograft nephropathy due to hyperlipidemia.
- Promoter polymorphisms have a role in susceptibility to atopic dermatitis in a Japanese population.
- the differential regulation of expression by PKCalpha/beta in lung adenocarcinoma cells
- polymorphisms investigated are not associated with chronic periodontitis
- Antiviral gene expression in RA, especially due to TLR ligands and TNFalpha, is dependent on IKKepsilon and IRF-3, and this pathway plays a key role in the production of type I IFNs and chemokines such as RANTES.
- the lung epithelial cell is a possible target of dengue viruses and IL-6 and RANTES may play pivotal roles in lung related immuno-pathogenesis
- In this review we focus on the known polymorphisms of two chemokines: CCL2, CCL5 and their corresponding receptors (CCR2, CCR5) and we also discuss their associations with susceptibility and progression to selected immune-mediated diseases [REVIEW]
- Our study suggests that patients with the RANTES -403GG genotype have a lower incidence of recurrent acute rejection episodes in kidney transplantation
- renal compartments differ in their capacity to present chemokines, which may help explain the differential recruitment of leukocytes during allograft injury
- results of the present study demonstrate that the RANTES -403A allele is associated with lower serum RANTES concentrations and consequently with reduced coronary artery disease risk
- first report of an association between a functional promotor polymorphism in the RANTES gene, with an odds ratio of 4.16 for the development of primary sclerosing cholangitis in patients with Crohn's disease
- results suggest that RANTES -28G was associated with delayed AIDS progression, while DC-SIGN -139C was associated with accelerated AIDS progression in HIV-1-infected Japanese hemophiliacs.
- it is concluded that RANTES -28 G allele plays a role in the pathogenesis of SARS
- The Th1 cytokine IFN stimulated the expression of RANTES.
- The RANTES -403 G/A polymorphism was significantly associated with non-determined leukoencephalopathy
- HCV core protein have opposite effects on the expression of RANTES in different cell types in vitro, possibly reflecting a similar scenario in different microenvironments in vivo.
- in lupus nephritis RANTES may participate in interstitial lesions via CCR5+ cells
- RANTES, MCP-1, CCR2, CCR5, CXCR1 and CXCR4 gene polymorphisms do not have a role in progression of hepatitis B virus infection
- A significant correlation exists between bronchoalveolar lavage concentration of CCL5 and eosinophils in veterans with sulfur mustard gas-induced pulmonary fibrosis.
- findings support the association between RANTES functional polymorphisms and tuberculosis
- RANTES signaling is required for invasion in TGFbetaRII-deficient neoplastic cells.
- The levels of intralesional expression of mRNA of tumor necrosis factor-alpha, interferon, interleukin-10, RANTES, and indoleamine-2,3-dioxygenase in Mediterranean spotted fever are reported; levels of inducible nitric oxide synthase are also reported.
- Our data suggest that -28 C/G and -403 G/A polymorphisms within the RANTES promoter region play an important role in asthma predisposition and in the severity of airway obstruction.
- Women with endometriosis had increased peritoneal mRNA expression of RANTES and VCAM-1 during menstrual compared with luteal phase.
- Results showed there were no associations of MCP-1 and RANTES promoter SNPs with diabetic ESRD in Korean population.
- In summary, our multifaceted study supports the notion that polymorphisms in CCL5 and CCR5 modify the course of MS.
- CCL18 and CCL5 are transiently raised during episodes of UAP, and peak levels of both chemokines are indicative of refractory symptoms.
- CCL5 has a role in leukocyte trafficking and may be involved with the development of cGVHD
- The PD group presented with significantly increased RANTES levels as compared to the control group. A strong and significant correlation between RANTES levels and UPDRS III score was observed in PD patients.
- The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma.
- The frequency of the RANTES-403G allele was significantly higher in patients with stenosis >70% (OR, 2.45; 95% CI 1.12-5.71; p=0.015).
- This observation supports the previously reported results indicating RANTES as an important mediator of Respiratory Syncytial Virus infection.
- Human CCL5/RANTES gene promoter polymorphisms are not associated with the different types of bronchial asthma in Spanish population
- data suggest that SDF-1 G801A and RANTES-28 polymorphisms are not associated with the genetic susceptibility to systemic lupus
- We show that the level of CCL5 production is a main factor determining CD4+ T cell surface CCR5 density.
- secretion of RANTES by human leukocyte antigen-A2-restricted tyrosinase-specific cytotoxic T lymphocyte in the context of human melanoma cell killing
- Genetic variation of CCL5 might be an important risk factor for albuminuria in the non-diabetic Japanese general population.
- RANTES-28G and CCR5 59353C mutations might be associated with HIV infection or pathogenesis in the Korean population.
- Our data indicate that women who inherit A allele at RANTES -403 may be at reduced risk for gastric cancer.
- chemokine CCL5 may induce migration of leukocytes to the central nervous system in multiple sclerosis
- mechanism by which CCL5 influences translation of rapamycin-sensitive
- CC chemokine ligand 5 gene may be part of a common pathway in the pathogenesis of late-onset asthma and chronic obstructive pulmonary disease with milder emphysema
- CCL5 was significantly increased in Graves' disease patients compared with Hashimoto's thyroiditis or nontoxic nodular thyroid disease subjects.
- RANTES/CCL5 gene variants and serum levels are not causally related with type 2 diabetes and that elevated RANTES levels in patients with type 2 diabetes may be a consequence of hyperglycemia
- The overall current information suggests that CCL2 and CCL5 are inflammatory mediators with pro-malignancy activities in breast cancer.
- results implicate that RANTES In1.1 T allele and haplotype II (ACT) may be a risk factor for HIV-1 transmission while RANTES In1.1 C allele may be risk factor for disease progression among North Indians
- analysis of binding of CC-chemokine receptor 1 (CCR1) to CC-chemokine 3 and 5 (CCL3 and CCL5)
- Data show that basal level of RANTES is higher in Parkinson's disease patients than in healthy control subjects.
- the RANTES G-403A allele increased the relative risk for cerebral infarction in the subjects without the IL-4 VNTR allele 3
- findings suggest that platelet activation, resulting in elevated RANTES release, could be one of the factors responsible for the increase of airway inflammation observed in consequence of exercise-induced bronchoconstriction in asthmatics
- observations support a major tumor-promoting role for co-expression of the chemokines in breast malignancy, and agree with the significant association of joint RANTES and MCP-1 expression with advanced stages of breast cancer.
- Among three possible YB-1 binding sites in the CCL5 promoter, a critical element was mapped at -28/-10 bps. This site allowed up-regulation of CCL5 transcription in human monocytes; however, it repressed transcription in differentiated macrophages
- RANTES promotes an adequate pro-implantatory microenvironment that influences trophoblast cell survival and modulates the balance of maternal Treg/T effector lymphocytes in favor of maternal tolerance.
- Cigarette smoke extract plus dsRNA induces exaggerated epithelial RANTES expression in patients with CRS.
- Because the phenotypic consequence of -403A is reported to be higher levels of RANTES, we propose a model in which excess RANTES in combination with low CCR5 favors recovery from an HBV infection
- results suggest that CCL5 acts through PI3K/Akt, which in turn activates IKKalpha/beta and NF-kappaB, resulting in the activation of alphavbeta3 integrin and contributing to the migration of human lung cancer cells
- A alleles in TNF-A and RANTES influenced prostate cancer susceptibility and acted independently of each other in these subjects. No epistatic effect was found for the combination of different polymorphisms studied.
- Unlike in T cells, CCL5/RANTES messenger RNA is constitutively transcribed and translated in peripheral blood natural killer (NK) cells; CCL5 protein is localized to secretory vesicles that are distinct from the cytolytic granules.