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Validated All-in-One™ qPCR Primer for SATB1(NM_001322874.2) Search again
Product ID:
HQP160525
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
DEFDA, DHDBV, KTZSL
Gene Description:
SATB homeobox 1
Target Gene Accession:
NM_001322874.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- Two strong SATB1 binding sites, located 4.5 kb apart, have been detected in strong matrix attachment regions of the candidate regulatory region of the CD8 gene complex.
- SATB1 targets chromatin remodelling to the IL-2Ralpha ('interleukin-2 receptor alpha') gene
- SATB1 makes a complex, mainly with p300, regardless of the presence of DNA; SATB1/p300 complex binding to the 5' upstream AT-rich region in the bp -115 to bp -106 segment and represses the gp91(phox) promoter activity
- SATB1 family protein expressed in the erythroid progenitor cells may have a role in globin gene expression during early erythroid differentiation.
- SATB1-mediated transcriptional repression is regulated by nuclear matrix binding
- SATB1 N-terminal residues 20-40 represent a novel determinant of nuclear targeting
- SATB1 possesses a DNA-binding mode similar to that of the POU-specific DNA-binding domain, which is known to share structural similarity to the four-helix CUT domain
- SATB1 formed special three-dimensional network distributions during early apoptosis. The distribution change of SATB1 was associated with cleavage of the protein and accompanied by the nuclear architecture collapse.
- Phosphorylation of SATB1 acts as a molecular switch regulating its transcriptional activity in vivo.
- Our studies identify PML and SATB1 as a regulatory complex that governs transcription by orchestrating dynamic chromatin-loop architecture.
- Results show for the first time that forced-expression of SATB1 in K562 cells triggers SPARC up-regulation by binding to a 17bp DNA sequence in the third intron.
- SATB1-mediated assembly of chromatin in T cells may play a role in integration site selection by HIV-1.
- Determination of the crystal structure of the complex of the CUT domain of SATB1 and a matrix attachment region DNA, in which the third helix of the CUT domain deeply enters the major groove of DNA in the B-form.
- SATB1 reprogrammes chromatin organization and the transcription profiles of breast tumours to promote growth and metastasis; this is a new mechanism of tumour progression
- SATB1 has a role in controlling transcription in immune cells during normal cell functions or in assisting in efficient and rapid clearance of nonfunctional or potentially damaging immune cells through its action with SUMO
- SATB1 is a master regulator in the metastasis of breast cancer and, therefore, can be considered as an independent prognostic factor and a potential therapeutic target for breast cancer
- role of SATB1-CtBP1 interaction in the repression and derepression of SATB1 target genes during Wnt signaling in T cells