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Validated All-in-One™ qPCR Primer for S100A8(NM_001319201.2) Search again
Product ID:
HQP160482
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8, S100-A8
Gene Description:
S100 calcium binding protein A8
Target Gene Accession:
NM_001319201.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs.
Gene References into function
- examination of whether the prevalence of somatic p53 mutation in gastric adenocarcinoma differed between subjects with and without infection with CagA(+) (a marker for the PAI) H. pylori strains
- These data indicate that calprotectin (MRP8 and MRP14)has higher specific activity to induce apoptosis than the individual subunits, and that the mechanism is exclusion of zinc from target cells.
- Proinflammatory myeloid-related protein S100A8 induces a dose- and time-dependent activation of the HIV-1 long terminal repeat promoter region that can be blocked by specific polyclonal antibody and by physical denaturation of the protein.
- Extensive expression of S100A8 and S100A9 defines a novel inflammatory disorder.
- S100A8 and S100A9 calcium-binding proteins: localization within normal and cyclosporin A-induced overgrowth gingiva, in spino-cellular layer and extracellularly in desmosomes, in cytoplasm and nuclei.
- S100A8 stimulates shedding of L-selectin, up-regulates and activates Mac-1/CD11b, induces neutrophil adhesion to fibrinogen in vitro, and is involved in neutrophil migration to in vivo inflammatory sites.
- plays a prominent role in leukocyte trafficking and arachidonic acid metabolism; elevated levels of S100A8 and S100A9 in body fluids of inflamed tissues strengthen the view that these molecules are important players in fighting inflammation [review]
- S100A8 and S100A9 induce inflammatory activation of endothelial cells [review].
- increased levels in fetal disease, premature rupture of membranes, and preterm labor
- MRP8/MRP14 dimer behaves as a positive mediator of phagocyte NADPH oxidase regulation
- Activated macrophages can promote destruction and impair regeneration of myocytes during the course of inflammatory myopathies via secretion of S100A8 and S100A9.
- Since MRP-8/MRP-14 exhibit direct effects on leukocyte adhesion to the vascular endothelium, their extensive expression in the epidermis indicates an active role for these S-100 proteins in the initial phase of this systemic autoimmune disease.
- decreased expression of MRP8 and MRP14 might play an important role in the pathogenesis of human esophageal squamous cell carcinoma, being particularly associated with poor differentiation of tumor cells.
- The complex of S100A8 and S100A9 promotes tubulin polymerization and integrates mitogen-activated protein kinase- and calcium-dependent signals during migration of phagocytes.
- expression of MRP8/MRP14 closely correlated with the inflammatory activity in systemic vasculitis
- S100A8/A9 promotes phagocyte NADPH oxidase activation by supplying the enzyme with its cofactor arachidonic acid
- Calgranulin A and chaperonin 10 are identified as markers for diagnosis and screening of endometrial carcinoma.
- data suggest that enhanced expression of S100A8, S100A9, and RAGE is an early event in prostate tumorigenesis and may contribute to development and progression or extension of prostate carcinomas
- S100A8 and S100A9 in atherosclerotic plaque and calcifying matrix vesicles may significantly influence redox- and Ca2+-dependent processes during atherogenesis
- heterodimeric S100 calcium binding protein A8/S100 calcium binding protein A9 might play a hitherto unknown role in triggering atherosclerosis in diabetes and renal failure
- S100A8/A9 heterodimer, secreted extracellularly from activated tissue macrophages, may amplify proinflammatory cytokine responses in rheumatoid arthritis.
- calcium-dependent formation of (S100A8/S100A9)2 tetramers is an essential prerequisite for biological function.
- MRP-8/14 was mainly detected in human cervical mucus and showed a positive correlation with proinflammatory cytokines
- MRP-8/MRP-14 are exclusively secreted by granulocytes in patients with acute Kawasaki disease, and intravenous immune globulin treatment suppresses their gene expression.
- Zinc-binding, like calcium, induces (S100A8/S100A9)(2)-tetramers.
- The G+ genotype/G allele may be considered to exert a significant protective effect in males against aggressive periodontitis.
- S100A8 and S100A9 are involved in the innate defense of the bronchial epithelium
- the effect of calcium on telomerase in the human epidermal keratinocyte line HaCaT showed calcium directly interacts with the telomerase complex. This interaction could be mediated by the calcium-binding protein S100A8
- HaCaT keratinocytes overexpressing the S100 proteins S100A8 and S100A9 show increased NADPH oxidase and NF-kappaB activities.
- Correlation of the expression of S100A8 and S100A9 revealed that the microenvironments of tumours which lacked expression of Smad4, had significantly reduced numbers of S100A8-immunoreactive (p = 0.023) but not S100A9-immunoreactive (p = 0.21) cells.
- mechanism of S100A8 in the oncogenesis and development of laryngeal cancer
- Report showed S100A8 was expressed human bone and cartilage cells and may contribute to calcification of the cartilage matrix and its replacement with trabecular bone, and to regulation of redox in bone resorption.
- S100A8 is regulated by IL-17, dexamethasone, IL-4 and IL-13 in HaCat cells (human keratinocyte cell line)
- Data suggest that S100 proteins calprotectin and S100A12 are related to radiographic changes rather than disease activity in psoriatic arthritis with low disease activity.
- Serum calprotectin (S100A8/S100A9)and S100A12 are increased in children with inflammatory bowel disease and indicate disease activity.
- MRP8/14 may be involved in the pathogenesis of sarcoid granulomas. The measurement of serum MRP8/14 levels is useful for the diagnosis of sarcoidosis.
- The homo-oligomeric forms of S100A8 and S100A9 are readily degraded by proteases, and the preferred hetero-oligomeric S100A8/A9 complex displays a high resistance even against proteinase K degradation.
- presence of a positive feedback loop for growth stimulation involving S100A8/A9 and cytokines in human epidermal keratinocytes
- These data indicate that S100A8/A9-induced cell death involves Bak, selective release of Smac/DIABLO and Omi/HtrA2 from mitochondria, and modulation of the balance between pro- and anti-apoptotic proteins.
- S100A8/A9-promoted cell growth occurs through RAGE signaling and activation of NF-kappaB.
- Seven placental transcripts characterize HELLP-syndrome.
- It is suggested that S100A8 is S100A9-dependently expressed and acquires the protein stability by S100A8/A9 heterocomplex formation; S100A8 and S100A9 overexpression should be considered marker of poor prognosis in invasive ductal carcinoma
- Expression of S100A7 and S100A8 was significantly decreased in CRS with and without nasal polyps when compared with controls.
- RAGE, carboxylated glycans and S100A8/A9 play essential roles in tumor-stromal interactions, leading to inflammation-associated colon carcinogenesis.
- annexin A6 contributes to the calcium-dependent cell surface exposition of the membrane associated-S100A8/A9 complex
- S100A8-SNO may regulate leukocyte-endothelial cell interactions in the microcirculation, and suppression of mast cell-mediated inflammation represents an additional anti-inflammatory property for S100A8.
- This study revealed S100A8/A9 genes as candidate markers for metastatic potential of breast epithelial cells.
- Data indicate that both S100A8 and S100A9 are required for their fully active antifungal effect and that oxidation regulates S100A8/A9 antifungal activity through mechanisms that remain to be elucidated and evaluated.
- S100A8 was induced in human monocytes and macrophages, by polyinosinic:polycytidylic acid, a dsRNA mimetic