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Validated All-in-One™ qPCR Primer for RAD51C(NM_058216.3) Search again
Product ID:
HQP159913
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
BROVCA3, FANCO, R51H3, RAD51L2
Gene Description:
RAD51 paralog C
Target Gene Accession:
NM_058216.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself.
Gene References into function
- This work describes the in vitro and in vivo identification of the RAD51B/RAD51C heterocomplex
- Rad51B and Rad51C function through interactions with the human Rad51 recombinase and play a crucial role in the homologous recombinational repair pathway
- analysis of protein domains important for functioning of RAD51L2; there is a specific requirement for RAD51L2 in gene conversion in mammalian cells
- a fragment of Rad51B containing amino acid residues 1-75 interacts with the C-terminus and linker of Rad51C, residues 79-376, and this region of Rad51C also interacts with mRad51D and Xrcc3
- concluded that the RAD51 paralogs are involved in Holliday junction processing in human cells
- cellular evidence for the function of human Rad51C in homologous recombinational repair
- Rad51C plays an important role in regulating Rad51 degradation via the ubiquitin-mediated proteasome pathway.
- RAD51C ensures a tight regulation of RAD51 assembly during DSB repair and plays a direct role in repairing DSBs in vivo.
- the RAD51C-XRCC3-associated Holliday junction resolvase complex associates with crossovers and may play an essential role in the resolution of recombination intermediates prior to chromosome segregation