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Validated All-in-One™ qPCR Primer for PEX19(NM_002857.4) Search again
Product ID:
HQP159774
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
D1S2223E, HK33, PBD12A, PMP1, PMPI, PXF, PXMP1
Gene Description:
peroxisomal biogenesis factor 19
Target Gene Accession:
NM_002857.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene is necessary for early peroxisomal biogenesis.
Gene References into function
- LDRP (ABCD2) interacts with both farnesylated wild-type and farnesylation-deficient mutant PEX19. This interaction is mediated by amino acids 1-218 of ALDRP.
- MP70 (ABCD3) interacts with both farnesylated wild-type and farnesylation-deficient mutant PEX19.
- ALDRP interacts with PEX19 splice variants PEX19-delta-E2 and PEX19-delta-E8.
- MP70 interacts with PEX19 splice variants PEX19-delta-E2 and PEX19p-delta-E8.
- a considerable functional diversity of the proteins encoded by two PEX19 splice variants and thereby provide first experimental evidence for specific biological functions of the different predicted domains of the PEX19 protein.
- PEX19 binds and stabilizes newly synthesized PMPs in the cytosol, binds to multiple PMP targeting signals (mPTSs), interacts with the hydrophobic domains of PMP targeting signals, and is essential for PMP targeting and import.
- Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET).
- Pex19p has a role in assembly of PTS-receptor docking complexes
- Results suggest that PEX3 plays a selective, essential, and direct role in class I peroxisomal membrane protein import as a docking factor for PEX19.
- human Pex19p domain architecture and activity
- analysis of the PEX19-binding site of human adrenoleukodystrophy protein
- Pex19p translocates the membrane peroxins from the cytosol to peroxisomes in an ATP- and Pex3p-dependent manner and then shuttles back to the cytosol
- Pex19p binds to PMP70 co-translationally and keeps PMP70 in a proper conformation for the localization to peroxisome.
- Nonfarnesylated and farnesylated human Pex19p display a similar affinity towards a select set of peroxisomal membrane proteins.
- Data suggest that Pex19p probably functions as a chaperone for membrane proteins and transports them to peroxisomes by anchoring to Pex3p using residues 12-73 and 40-131.
- either one or two tryptophan residues of Pex3p (Trp-104 and Trp-224) are directly involved in binding to Pex19p.
- targeting of hFis1 to peroxisomes and mitochondria are independent events and support a direct, Pex19p-dependent targeting of peroxisomal tail-anchored proteins.