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Validated All-in-One™ qPCR Primer for PTPRA(NM_002836.4) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation.
Gene References into function
- Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.
- In entering mitosis the cell cycle-specific regulation of c-Src by RPTPalpha can occur by dephosphorylation of phospho-Tyr527 that activates c-Src in a reaction catalyzed by the transmembrane receptor-like protein tyrosine phosphatase RPTPalpha.
- interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs
- RPTPs have the capacity for inside-out signaling
- This protein regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells.
- data suggest that receptor-like protein tyrosine phosphatase alpha acts as a receptor for Helicobacter pylori VacA toxin in G401 cells
- Receptor protein tyrosine phosphatase alpha signaling has a role in androgen depletion-induced neuroendocrine differentiation of prostate tumor cells
- These data reveal a functional relevance of PTP alpha for insulin secretion.
- PTPRA and PTPRZ may have roles in gastric cancer progression including lymphovascular invasion and liver/peritoneal dissemination
- the two splice variants of PTPalpha are expressed differentially and regulate c-Src activity in different ways.
- siRNA-mediated suppression of protein tyrosine phosphatase alpha (PTP alpha) reduces Src activity 2 to 4-fold in breast, colon and other human cancer cell lines.
- CD63 plays a role in the regulation of ROMK channels through its association with RPTPalpha, which in turn interacts with and activates Src family PTK, thus reducing ROMK activity.
- This study showed that PTPalpha is required for remodeling of focal adhesion during cell spreading via a pathway involving Rac1.
- report a statistically significant lower expression intensity of PTEN and HePTP
- RPTPalpha plays a critical role in HCN channel function via tyrosine dephosphorylation