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Validated All-in-One™ qPCR Primer for PTPN2(NM_001207013.2) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms.
Gene References into function
- Results identify TC45 as a protein tyrosine phosphatase responsible for the dephosphorylation of Stat1 in the nucleus.
- TcPTP phosphorylation is regulated by STAT1
- regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation
- TCPTP activates p53 and induces caspase-1-dependent apoptosis in a human tumor cell line.
- Insulin makes the TC48-D182A & TC45-D182A "substrate-trapping" mutants form stable complexes with the tyrosine-phosphorylated IR beta-subunit. Differentially localized TCPTP variants dephosphorylate the IR & downregulate insulin signaling in vivo.
- An important function of TC-PTP is the induction of the nitric oxide pathway that mediates inhibition of T cell proliferation.
- Tc-PTP has a novel role in the regulation of type 1 interferon-stimulated gene expression
- in a STI571-resistant CML sublines, TC-PTP was markedly downregulated. TC-PTP-transduced cells showed dramatic decrease of STAT5 phosphorylation and restored sensitivity to imatinib mesylate as monitored by reduced proliferation and increased apoptosis
- Data suggest that TC48 translocates to the Golgi complex along the secretory pathway, whereas its endoplasmic reticulum localization is maintained by selective retrieval enabled by interactions with p25 and p23.
- Single nucleotide polymorphism in PTPN2 gene is associated with ulcerative colitis
- PTP1B and TCPTP play distinct and non-redundant roles in the regulation of the Met receptor-tyrosine kinase
- matrix-controlled TCPTP phosphatase activity can inhibit VEGFR2 signalling, and the growth, migration and differentiation of human endothelial cells
- TCPTP is a negative regulator of SFK, JAK1 and STAT3 signalling during the cell cycle.