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Validated All-in-One™ qPCR Primer for KLK6(NM_002774.4) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.
Gene References into function
- characterization of human kallikrein 6 as a degradative protease with structural features more similar to trypsin than the regulatory kallikreins
- X-ray crystallographic structure of KLK6.
- Kallikrein 6, a myelencephalon-specific protease expressed in the adult central nervous system (CNS), is present in inflammatory CNS lesions (e.g., multiple sclerosis) and in excess promotes CNS demyelination.
- Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients
- Immunofluorometric quantitation and histochemical localisation of kallikrein 6 protein in ovarian cancer tissue: a new independent unfavourable prognostic biomarker.
- Decreased cerebrospinal fluid levels may be a posssible risk factor for Alzheimer's disease
- Characterization of the enzymatic activity of kallikrein 6.
- neurosin plays a significant role in physiological alpha-synuclein degradation and also in the pathogenesis of synucleinopathies
- Downregulation of kallikrein 6 is associated with breast cancer
- Distinct promoters regulate tissue-specific expression of KLK6 gene. Cloning of three novel transcript variants of KLK6 gene that encode for wild-type kallikrein 6 and of splice variants 2 and 3 produced by splicing out exons 3 and 4, respectively.
- The enzymatic activity of hK6 is regulated by an autoactivation/autoinactivation mechanism. Mature hK6 displayed a trypsin-like activity against synthetic substrates and human plasminogen was identified as a putative physiological substrate for hK6
- Human KLK6 might play a role in the invasion and metastasis of tumour cells and may be a candidate therapeutic target.
- Tissue-specific expression patterns and differential regulation in CNS disease indicates that each K6 5'-transcript is probably regulated by unique promoter elements and may serve as a molecular target to treat inflammatory demyelinating disease.
- Results indicated that KLK6 mRNA expression was significantly higher in cancerous than in noncancerous colorectal tissues.
- Kallikrein 6 is highly expressed in uterine serous papillary carcinoma (USPC) and is released in the plasma and serum and may represent a novel biomarker for USPC for monitoring early disease recurrence and response to therapy.
- KLK6 is markedly overexpressed in gastric cancer tissue
- hK6 expressed in the central nervous system is involved in normal myelin turnover/demyelination processes, but it is unlikely to self-activate
- KLK6 may participate in epidermal desquamation through cleavage of desmoglein 1 and regulation by lympho-epithelial Kazal-type-related inhibitor (LEKTI).
- KLK6 displayed trypsin-like activity, with the P1 position occupied only by Arg and a strong preference for Ser in P1'.
- the oncogenic role of KLK6 in colorectal cancer
- Co-expression of KLK6 and KLK10 as prognostic factors for survival in pancreatic ductal adenocarcinoma.
- High tumor KLK6 protein expression is associated with inferior patient outcome in ovarian cancer.