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Validated All-in-One™ qPCR Primer for SRGN(NM_001321053.2) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, which may serve as a mediator of granule-mediated apoptosis.
Gene References into function
- proapoptotic granzyme is exocytosed predominantly as a macromolecular complex with serglycin
- cell- and differentiation-specific alterations in chromatin structure may control serglycin gene expression
- serglycin-bound granzyme B in high-molecular-weight degranulate material from cytotoxic T lymphocytes predominantly followed a dynamin-dependent pathway to kill target cells
- mechanism of delivery is proposed entailing electrostatic transfer of granzyme B from serglycin to cell surface proteins
- Serglycin release is a constitutive process, which may be of fundamental biological importance in the study of multiple myeloma.
- Mutations in SRGN is not associated with familial hemophagocytic lymphohistiocytosis