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Validated All-in-One™ qPCR Primer for PPY(NM_002722.5) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene belongs to the NPY family and it encodes a protein that is synthesized as a 95 aa polypeptide precursor in the pancreatic islets of Langerhans. It is cleaved into two peptide products; the active hormone of 36 aa and an icosapeptide of unknown function. The hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain.
Gene References into function
- Distribution of pancreatic polypeptide and peptide YY
- Pancreatic polypeptide in pancreatitis
- Pancreatic polypeptide-related tumors
- Autonomic neuropathy is associated with impaired neuropeptide Y and this peptide responses to insulin-induced hypoglycaemia in Type I diabetic patients.
- Early postprandial insulin and PP secretory responses were higher in Pima Indians compared with those of Caucasians.
- Pancreatic polypeptide contributes to the regulation of energy balance in humans.
- in healthy humans the presence of fat in the small intestine suppresses ghrelin secretion, and fat-induced suppression of ghrelin and stimulation of peptide YY and pancreatic polypeptide is dependent on fat digestion
- Inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. Is suggested to have physiological role in pancreatic postprandial counterregulation of gastric emptying and insulin secretion.
- human pancreatic polypeptide inhibits TFF2 secretion in a diurnal rhythm
- Age and sex may modulate the association between plasma PP level and the intra-abdominal fat area, suggesting that they may be determinants of parasympathetic activity.