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Validated All-in-One™ qPCR Primer for PPM1B(NM_002706.6) Search again
Product ID:
HQP159052
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
PP2C-beta, PP2C-beta-X, PP2CB, PP2CBETA, PPC2BETAX
Gene Description:
protein phosphatase, Mg2+/Mn2+ dependent 1B
Target Gene Accession:
NM_002706.6(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways.
Gene References into function
- PP2Cbeta down-regulates cytokine-induced NF-kappaB activation by altering IKK activity.
- Overexpression of PPM1A and the related PPM1B greatly reduced Cdk9 T-loop phosphorylation
- Protein phosphatase 1B is mediated dephosphorylation and inactivation of I-kappa B kinase as well as the termination of the Tumor Necrosis Factor-alpha-induced NF-kappaappaB activation.