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Validated All-in-One™ qPCR Primer for PHB1(NM_001281496.2) Search again
Product ID:
HQP158612
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HEL-215, HEL-S-54e, PHB
Gene Description:
prohibitin 1
Target Gene Accession:
NM_001281496.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Prohibitin is an evolutionarily conserved gene that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations in PHB have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region. The longer transcript is present at higher levels in proliferating tissues and cells, suggesting that this longer 3' untranslated region may function as a trans-acting regulatory RNA. [provided by RefSeq].
Gene References into function
- Data show that prohibitin recruits Brg-1/Brm to E2F-responsive promoters, and that this recruitment is required for the repression of E2F-mediated transcription by prohibitin.
- Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis.
- appears to repress E2F-mediated transcription utilizing different molecular mediators and facilitate channeling of specific signaling pathways to the cell cycle machinery
- The prohibitin 3' untranslated region polymorphism is not associated with risk of ovarian cancer.
- Prohibitin appears to induce p53-mediated transcription by enhancing its recruitment to promoters
- Here we show that the E2F1 binding domain of prohibitin has the potential to fold into a coiled-coil structure.
- PHB is required for growth suppression by estrogen antagonists.
- Data indicate that the novel 3' untranslated region of prohibitin influences not only the tumorigenic phenotype but also may play a role in differentiation and migration of breast cancer cells.
- PHB might be a useful therapeutic approach for the treatment of variety of disease states, including inflammation, obesity and cancer.
- Prohibitin plays a role in the activation of the Ras-Raf signalling pathway and in modulating epithelial cell adhesion and migration.
- Findings in this review demonstrate an unexpected role of PHB in the control of a central signaling pathway involved in cell growth and malignant transformation.
- study demonstrated that prohibitin 1 may be activated at the early stage of glandular neoplasia of the uterine cervix
- These studies show that prohibitin plays a vital role in inducing cellular senescence.
- These studies show that prohibitin can have diverse effects on the expression of different genes and the activity of various cellular promoters is affected by prohibitin
- TGF-ss mediated the nuclear export of prohibitin, a protein involved in androgen-regulated prostate growth, to the cytosol in prostate cancer cells.
- appears then that repression of androgen receptor (AR) activity is one mechanism by which prohibitin inhibits androgen-dependent growth of prostate cells
- the PHB 3'UTR T allele increases the risk of breast cancer in patients who are already at increased risk of disease.
- PHB protein was positively expressed at normal renal tissues, strongly down-regulated in renal biopsy specimens, and negatively correlated with the expression of alpha-smooth-muscle actin (alpha-SMA) and with the degrees of tubulointerstitial lesions.
- A significant reduction of prohibitin and ATP synthase was observed in the substantia nigra in PD cases. In contrast, increased prohibitin and ATP synthase levels were found in the frontal cortex in PD.
- The prohibitin 3' UTR polymorphism was not associated with risk and prognosis of ovarian cancer in Caucasian women.
- With RNF2, regulates the activity of E2F1 transcription factor via dual pathways.
- Results indicate that PHB functions as a transcriptional corepressor for ERalpha in vitro and in vivo, and that its heteromerization with REA acts as a novel mechanism to limit its corepressor activity.
- Phb1 and Phb2 are novel phosphoproteins up-regulated during T cell activation that function to maintain mitochondrial integrity
- Phb1 over-expression induced cellular resistance to Staurosporine via the intrinsic apoptotic pathway. Phb1 induces block at G0/G1 phase of the cell cycle and promotes survival of cancer cells.
- PHB1 maintains the organization and copy number of the mtDNA through both TFAM-independent and -dependent pathways.
- The prohibitin 3'UTR C-to-T transition variant is not associated with the risk of breast cancer in Turkish women.
- PHB could be a potential diagnostic and differentiation biomarker of gastric cancer for tissue-based detection by immunohistochemistry and real-time PCR, but not for serum-based detection.
- PHB is a nuclear matrix protein, which is located in the nuclear matrix, and the distribution and expression of PHB and its relation with associated genes may play significant roles during the differentiation of SMMC-7721 hepatocarcinoma cells
- MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin
- This protein has been found differentially expressed in the temporal lobe from patients with schizophrenia.