|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for OPRM1(NM_000914.5) Search again
Product ID:
HQP158060
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
LMOR, M-OR-1, MOP, MOR, MOR1, OPRM
Gene Description:
opioid receptor mu 1
Target Gene Accession:
NM_000914.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin: SNPs were detected, one in exon3, one in intron3 and one in the 3' untranslated region
- expression activates map kinases in cord blood hematopoietic stem cells
- Two C-terminal amino acids, Ser(355) and Thr(357), required for short-term homologous desensitization of mu-opioid receptors.
- dimerization of mu-opioid receptor expressed in insect cells
- Lack of association of a single-nucleotide polymorphism of the mu-opioid receptor gene with anxiety-related traits
- Association of micro -opioid receptor subunit gene and idiopathic generalized epilepsy.
- A118G single nucleotide polymorphism of the mu-opioid-receptor is among the protective factors against morphine-6-glucuronide-related opioid toxicity
- These results suggest that oligomerization of chemokine receptor CCR5 and opioid receptors mu, delta and kappa on the cell membrane of human or monkey lymphocytes may modulate receptor functions.
- two new human mu opioid receptors are the first human MOR-1 variants containing new exons and suggest that the complex splicing present in mice may extend to humans
- This study suggested that there was significant population difference in the genotype distribution and allel frequency for the A118G and C17T polymorphisms in exon 1 of the OPM1 gene.
- An alternatively spliced variant of the mu opiate receptor, mu3, is expressed on monocytes, granulocytes, and vascular endothelial cells that do not express the mu1 opiate receptor subtype.
- interactions between helix VIII of the human mu-opioid receptors and the C terminus of periplakin disrupt G protein activation
- OPRM1 may play a role in the pathophysiology of substance dependence and this role is population- and diagnostic-specific.
- Genotyping of subjects with severe opioid dependence ( African-Americans amd European-Americans) and control subjects at SNPs in the OPRM1 gene.
- substance P receptor dimerization with micro-opioid receptor, sequestering MOR-1 via an endocytotic pathway with delayed recycling and resensitization kinetics.
- Mu opioid receptor gene polymorphism and neuroleptic-induced tardive dyskinesia in patients with schizophrenia.
- Results show a strong functional relationship between alcohol craving, mood, and mu-OR binding in specific brain regions of recently abstinent, alcohol-dependent men.
- amino acid substitution single-nucleotide polymorphism increrases risk of heroin asddiction in Swedish population.
- FIndings fail to support the hypothesis that Asn40Asp alleles moderate the development of personality dimensions, as measured by the Five-Factor Model.
- importance of STAT3 signaling in the regulation of neuronal growth and differentiation by the mu-opioid receptor.
- NRSF can function as a repressor of MOR transcription in specific cells, via a mechanism dependent on the mu opioid receptor gene neuron-restrictive silencer element
- Interleukin-6 strongly induces mu-opioid receptor mRNA in the human neuroblastoma cell line SH SY5Y.
- The individual variations in mu receptor expression in these vascular tissues may explain the large variance in graft survival
- alpha(2A)-AR and MOR hetero-oligomers, although they occur, do not have an obligatory functional influence on one another
- OPRM1 may be a pain-relevant gene
- No association has been revealed for the OPRM1 genotype and Korean patients with alcoholism compared to Korean control subjects without alcoholism.
- 26-bp polypyrimidine stretch in MOR proximal promoter interacts with these PCBPs and activates MOR transcription
- expression of the mu opioid receptor gene in lymphocytes is subject to the regulation of cis-elements upstream from the transcription initiation site
- OPRM1-G118 is a functional variant with deleterious effects on both mRNA and protein yield
- investigation of the ability of different opioid receptors to regulate the phosphorylation and degradation of tuberin
- Nncoding region in the human OPRM1 gene should lead to a better understanding of the mechanisms underlying OPRM1 gene regulation and individual differences in sensitivity to opioids.
- Polymorphisms in the mu-opioid receptor gene may potentially alter the clinical effects of opioid analgesics.
- OPRM1 gene plays a role in T2DM susceptibility in African Americans.
- OPRM1 intronic variants play a role in susceptibility to alcohol dependence and/or drug dependence in populations of European ancestry
- SV1 and SV2 proteins are possible biological modulator of human mu-opioid receptor.
- These results suggest that OPRM1 118G in addition to ALDH2 1510G might be one of the risk factors for alcohol dependence in Japanese people.
- Results suggest that alterations in mu opioid receptors (OPRM1) and opioid neuropeptide systems might underlie enhanced opiate abuse vulnerability apparent in 118G polymorphic individuals.
- Subjects with at least one copy of the 118G allele have increased basal levels of cortisol, which may influence the susceptibility to the stress responsive dyscrasia.
- Changes in the inhibitory effects of opioid receptor agonists on intracellular cAMP were used as a marker of the function of mu opioid receptors.
- Opioid receptor mu agonist morphine acts via inhibition of adenylate cyclase to inhibit protein kinase A-potentiated TRPV1 responses.
- transcriptional regulation of MOR1 is modified by two genetic variations at positions of the mu-opioid receptor promoter
- mu-opioid receptor expression is down-regulated in SH SY5Y neuroblastoma cells by IFN-gamma
- Study provides initial evidence for an association of the OPRM1 A118G variant with nicotine reinforcement in women.
- Synaptophysin plays an important role in the regulation of micro-opioid receptor trafficking and signaling.
- The major function of PKCI-1 is to modulate mu opioid receptor signaling pathway along with RGSZ1, rather than directly mediating the Galphaz RGSZ1 interaction.
- Polymorphisms in genes coding for the mu-opioid receptor (A118G) and catechol-O-methyl transferase (Val158Met) may be important modulators of opioid efficacy
- it was observed that specific OPRM1 tSNPs were strongly associated with heroin-induced positive responses on first use
- The OPRM1 118A > G polymorphism specifically modulates nociceptive but not nonnociceptive cortical activation.
- OPRM1 G allele carriers reported significantly more craving for alcohol than the A allele participants
- OPRM1 genotype may moderate the effect of transdermal nicotine patch compared to placebo during active treatment.
- Reults describe the role of mu opioid receptors and S1P3 transactivation in the attenuation of vascular permeability by methylnaltrexone.
- Although a role of OPRM1 polymorphisms in determining risk for opioid dependence cannot be entirely discounted, a major contribution of the Asn40Asp polymorphism seems unlikely
- The role of the stress hormone beta-endorphin in several mechanisms that contribute to a dysbalance of human endothelial and monocytic endothelin (ET)-1 and nitric oxide (NO) release, mediated by mu1-opioid receptors, is studied.
- Placebo treatment affected endogenous opioid activity in a number of predicted mu-opioid receptor-rich regions that play central roles in pain and affect
- Findings suggest that interaction between CREB1 and OPRM1 may be important in nicotine reward.
- alteration of the beta(2) adrenergic receptor and the mutant mu opioid receptor in their C termini can expose determinants with affinity for GASP binding and consequently target receptors for degradation
- MORs were found in the nuclei of colonocytes and immune cells of the lamina propria in tumor-free tissue. In tumor tissue, immunoreactivity was found in the membrane and often in the nuclei of tumor cells
- Fibromyalgia patients display reduced mu-opioid receptor availability in several brain regions associated with pain modulation, including nucleus accumbens, amygdala and the dorsal cingulate.
- Variant A118G mu opioid receptors showed only a minor difference in cell surface binding capacity compared to the prototype, and no differences in cAMP EC(50) values.
- Pain relief variability was significantly (P<0.0001) associated with single-nucleotide polymorphism of the OPRM1 gene.
- Although these data do not provide support for the role of genetic variation in these mu-opioid-receptor-interacting proteins and smoking cessation, further exploration of opioid pathway genes in larger prospective pharmacogenetic trials may be warranted
- Clinical studies do not unequivocally support an association between polymorphisms in OPRM1 and alcohol dependence. [REVIEW]
- the cooperative interaction of Sp1 and YY1 transcription factors is the critical event triggering the initiation of transcription of the MOR gene in lymphocytes
- participants with one or two Asp40 alleles (n=16) had a significantly greater cortisol response to naloxone than Asn40 homozygotes, but the effect was limited to European Americans
- OPRM1 status did not moderate any of naltrexone's effects on alcohol drinking.
- A118g polymorphism in mu opioid receptor gene (oprm1)is association with opiate addiction in subjects of Indian origin.
- Increased mu opioid signalling requires an active conformation of the DOR and also results in activation of the Galpha subunit fused the DOR.
- genes encoding the mu-, delta-, and kappa-opioid receptors may contribute to variation in personality traits
- The functionally significant OPRM1 Asp40 allele predicts naltrexone treatment response in alcoholic individuals.
- the A118G SNP of the OPRM1 gene is associated with suicide.
- it is the constitutive activity inherent in the cannabinoid CB1 receptor that reduces the capacity of co-expressed mu opioid receptor to function
- IgG and IgA levels were also significantly different in individuals with different Mu opiate receptor genotypes.
- The mu opioid receptor mediates morphine-induced TNF and IL-6 inhibition in peptidoglycan-stimulated monocytes.
- plays a mandatory role in the analgesic properties of opioids and its polymorphism affects the mRNA expression and indivisual differences in sensitivity to opioids.
- Fentanyl inhibited gastric myoelectrical activity in about half of the subjects. The variation could not be explained by Single Nucleotide Polymorphism in the MOR gene.
- the minor allele, for most of the polymorphisms in the OPRM1 receptor gene investigated, was found to be associated with a more intense, and/or more adverse, response to alcohol
- This study have used immunohistochemistry and quantified the results to demonstrate that the levels of delta- and mu-OR subtypes were high in the VZ and SVZ between 11 and 16 gestation weeks (GW) and decreased by 20GW.
- The 102T/C OPRM1 gene polymorphism is associated with a better glucose tolerance and improved insulin sensitivity, both of which suggest a potential protective effect of this variant on T2DM risk.
- MOR gene expression is downregulated by opioid agonists and upregulated by opioid antagonists.
- response to nalmefene did not vary with genotype
- A118G polymorphism associated with functional neural changes in mesocorticolimbic structures after exposure to alcohol cues
- Results indicate that M6a modulates mu-opioid receptor endocytosis and post-endocytotic sorting and has an important role in receptor regulation.
- A pH-dependent effect was observed on the secondary structure of mu-opioid receptor solubilized in detergents, which demonstrates the essential role of ionic and hydrophobic interactions on the secondary structure.
- Methylation of cytosine:guanine dinucleotides in the OPRM1 promoter may lead to reduced OPRM1 expression in the lymphocytes of former heroin addicts.
- We explored associations of gene variants in the dopamine, opioid, and serotonin pathways with smoking reward ('liking') and reinforcement (latency to first puff and total puffs) as a function of negative mood.
- four patients and all mutations were novel (one patient had a DSG2 double mutation).
- genetic variation at position 118 of the mu-opioid receptor is associated with interindividual differences in pain scores, self-administered intravenous morphine, and the incidence of nausea postoperatively
- Those with at least one copy of the mu receptor A118G allele had a 48.6% good outcome if randomized to placebo but an 87.1% good outcome if randomized to naltrexone. T
- OPRM1 gene is involved in the prevalence of obesity in a Chinese population.
- data revealed that pressure pain threshold, but not tolerance, in subjects with the minor allele (termed 'GA') genotype of the IVS2+31G>A polymorphism of the OPRM1 gene was significantly higher than those with major allele (termed 'GG') genotype.