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Validated All-in-One™ qPCR Primer for OPRD1(NM_000911.4) Search again
Product ID:
HQP158052
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
DOP, DOR, DOR1, OPRD
Gene Description:
opioid receptor delta 1
Target Gene Accession:
NM_000911.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- These results suggest that oligomerization of chemokine receptor CCR5 and opioid receptors mu, delta and kappa on the cell membrane of human or monkey lymphocytes may modulate receptor functions.
- Gene may be linked to etiology of anorexia nervosa.
- random mutagenesis identified 30 activating point mutations. 3-D modeling revealed an activation path originating from the third extracellular loop and propagating through tightly packed helices III, VI and VII down to a VI-VII cytoplasmic switch.
- protein conformation and binding site for deltorphin ii
- interaction studies between the delta-opioid receptor, ligands, and G-proteins
- investigation of the ability of different opioid receptors to regulate the phosphorylation and degradation of tuberin
- Results describe the residues of the transmembrane helices 7 of delta and kappa opioid receptors that are on the water-accessible surface of the binding-site crevices.
- Results suggest that the OPRD1 gene variants may not be a factor in vulnerability to methamphetamine dependence/psychosis.
- Changes in the inhibitory effects of opioid receptor agonists on intracellular cAMP were used as a marker of the function delta opioid receptors (delta receptor).
- pharmacological chaperones facilitate plasma membrane targeting of delta-opioid receptors by binding and stabilizing receptor precursors, thereby promoting their release from the stringent ER quality control
- delta-opioid receptor phosphorylation regulates its beta-arrestins selectivity and subsequent receptor internalization and adenylyl cyclase desensitization
- The sarco(endo)plasmic reticulum Ca(2+) ATPase 2b (SERCA2b), which maintains high Ca(2+) concentration in the lumen of the endoplasmic reticulum, interacts specifically with the human delta opioid receptor.
- There is a positive haplotypic association between OPRd1 variants and substance dependence in European Americans.
- Increased delta opioid signalling is due to enhanced DOR coupling to its tethered Galpha subunit.
- With CXCR4 receptor, forms heterodimeric complexes that are dynamically regulated by the ligands.
- genes encoding the mu-, delta-, and kappa-opioid receptors may contribute to variation in personality traits
- Data show that CXCR2 chemokine receptor antagonism enhances delta opioid receptor (DOP) function via allosteric regulation of the CXCR2-DOP receptor heterodimer.
- DOP-R desensitization upon etorphine exposure relies on the GRK2, PKC and tyrosine kinases while DPDPE and deltorphin I mediate desensitization at least via tyrosine kinases.
- This study have used immunohistochemistry and quantified the results to demonstrate that the levels of delta- and mu-OR subtypes were high in the VZ and SVZ between 11 and 16 gestation weeks (GW) and decreased by 20GW.
- response to nalmefene did not vary with genotype
- N-glycosylation of the delta-opioid receptor is needed to maintain the expression of fully functional and stable receptor molecules at the cell surface
- Report human hepatic met-enkephalin and delta opioid receptor-1 immunoreactivities in viral and autoimmune hepatitis.
- Neither pressure pain threshold nor tolerance between major and minor alleles of other SNPs of the OPRM1, OPRK1, and OPRD1 genes were significantly different suggesting an association between the IVS2+31G>A SNP of OPRM1 gene and pressure pain sensitivity