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Validated All-in-One™ qPCR Primer for ROR1(NM_005012.4) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Gene References into function
- The ROR1 protein modulates the growth of neurites as well as their branching pattern in hippocampal neurons.
- finsings show ROR1 protein is selectively expressed on the surface of B-cell chronic lymphocytic leukemia (B-CLL) cells, whereas normal B cells, other normal blood cells, and normal adult tissues do not express cell surface ROR1
- ROR1 is an oncofetal surface antigen and survival-signaling receptor in chronic lymphocytic leukemia.
- Overexpression of orphan receptor tyrosine kinase Ror1 is associated with acute lymphoblastic leukemia
- The majority of CLL cells exhibited Ror1 surface expression (71% mean; range 36-92%). Two different variants of the Ror1 protein, 105 and 130 kDa, were identified.
- expression of ROR1 and WT1 in B-ALL is associated with the differentiation stage of the leukemic cells