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Validated All-in-One™ qPCR Primer for AFDN(NM_001207008.2) Search again
Product ID:
HQP157022
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
AF6, MLL-AF6, MLLT4, l-afadin
Gene Description:
afadin, adherens junction formation factor
Target Gene Accession:
NM_001207008.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
AF6 is a Ras (see HRAS; MIM 190020) target that regulates cell-cell adhesions downstream of Ras activation. It is fused with MLL (MIM 159555) in leukemias caused by t(6;11) translocations (Taya et al., 1998 [PubMed 9722616]).[supplied by OMIM].
Gene References into function
- This paper deals with AF-6 in mouse, rat, and cow.
- RYK, a catalytically inactive receptor tyrosine kinase, associates with EphB2 and EphB3 but does not interact with AF-6.
- Bcr kinase downregulates Ras signaling by phosphorylating AF-6 and binding to its PDZ domain
- Results report the solution structure of AF-6 PDZ domain and its interaction with the C-terminal peptides from Neurexin and Bcr.
- AF6 negatively regulates Rap1-induced cell adhesion.
- In the Acute Myeloid Leukemia patients, detected MLL rearrangements consisting of MLL/AF6, MLL/AF9, MLL/AF17 , MLL/ELL and MLL partial tandem duplication. MLL rearrangement include chromosome translocation and partial tandem duplication.
- Loss of afadin is associated with breast cancer
- AF6/s-afadin is a candidate for mediating control of cellular growth processes by regulated translocation to the nucleus.
- c-Src is recruited by AF-6 to cell-cell contact sites, suggesting that c-Src is regulated by a PDZ protein in special cellular locations.
- AF6 protein is important for spreading of Herpes simplex virus 1 in epithelial cells
- two distal surfaces of the AF-6 PDZ domain respond differently to peptide binding; distal surface 1 changes in millisecond dynamics, whereas distal surface 2 undergoes structural rearrangement