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Validated All-in-One™ qPCR Primer for MITF(NM_198159.3) Search again
Product ID:
HQP156955
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CMM8, COMMAD, MI, MITF-A, WS2, WS2A, bHLHe32
Gene Description:
melanocyte inducing transcription factor
Target Gene Accession:
NM_198159.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features.
Gene References into function
- MAZR and MITF synergistically transactivated the mMCP-6 gene. MAZR appeared to play important roles in the normal phenotypic expression of mast cells in association with MITF
- Microphthalmia-associated transcription factor (MITF) regulates the differentiation and development of melanocytes and retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Review.
- Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling
- MITF-M transactivates its own promoter (M promoter) by interacting with LEF-1
- Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability
- MITF regulates not only the expression of enzymes involved in melanin synthesis, but also the expression of a receptor which plays an essential role in melanocyte functions
- Beta catenin induced human melanoma growth requires the downstream target MITF
- MITF gene may be implicated in Waardenburg syndrome.
- MITF-M plays dual roles in the Wnt signaling pathway; MITF-M represents a downstream target and a nuclear mediator of Wnt signals in melanocytes
- Data show that MITF appears to regulate the expression of the SILV and MLANA genes.
- MITF expression in melanocytes is regulated by alpha-melanocyte-stimulating hormone modulated by SOX10
- MITF and STAT3 cooperatively induce c-fos, resulting in cellular transformation
- MITF as a major transcriptional regulator of studies identify MITF as a major transcriptional regulator of TRPM1 and suggest that its prognostic value may be linked to MITF-mediated regulation of cellular differentiation
- Mitf might play a role in the multinucleation process of giant cells and giant cell lesions.
- the functional consequences of MITF sumoylation depend on promoter context. Sumoylation provides a possible mechanism for altering the effects of MITF by affecting the target genes that it activates
- MITF regulates p16INK4A expression in melanocytes.
- The majority of isoforms were found to be broadly expressed, with the M- and Mc-isoforms being tissue-restricted to melanocytes and mast cells, respectively.
- Simultaneous expression of the EWSR1-ATF1 and MITF-M transcripts in clear cell carcinoma has led to the proposal that the MITF-M promoter is transactivated by EWSR1-ATF1.
- We therefore conclude that the alpha-MSH/cAMP pathway, using MITF as a signal transducer and HIF1alpha as a target, might contribute to melanoma progression.
- MITF represents a distinct class of 'lineage survival' or 'lineage addiction' oncogenes required for both tissue-specific cancer development and tumour progression
- These data suggest that MITF is an anti-proliferation factor that is down-regulated by B-RAF signaling and that this is a crucial event for the progression of melanomas that harbor oncogenic B-RAF.
- identified MITF as a new substrate of caspases and we characterized the cleavage site after Asp 345 in the C-terminal domain
- MITF, specifically MITF-M, is a key transcription factor for protein kinase C-beta (PKC-beta), linking the PKC- and cAMP-dependent pathways in regulation of melanogenesis
- The results of this study demonstrate a role for glutamate in MiTF regulation that may have implications in melanocyte associated disorders.
- c-Met expression is regulated by Mitf in the melanocyte lineage
- Mitf detection in blood can indicate subclinical metastatic disease and predict treatment outcome in melanoma patients.
- The transcription factor MITF is an amplified oncogene in melanoma that is critical for anchoring lineage dependence and malignant character.
- Sphingosylphosphorylcholine reduces melanin synthesis via MITF downregulation.
- Tacrolimus or cyclosporine A act on human osteoclast precursors in rheumatoid arthritis patients by targeting the calcineurin-dependent NFAT pathway and activation pathway for c-Jun or MITF.
- MITF and TFE3 reciprocally rescue one another in lines derived from CCS or pediatric renal carcinoma.
- Of special interest was the rapid decrease in expression of MITF in melanocytes treated with DKK1, which is concurrent with the decreased activities of beta-catenin and of glucose-synthase kinase 3beta.
- findings show that in melanomas invasiveness can be regulated epigenetically by Mitf, via regulation of the DIAPH1 gene; Mitf, via regulation of Dia1, can both inhibit invasiveness & promote proliferation
- MITF evokes transcription of a paradigmatic MITF target tyrosinase and show that the adenoviral E1A protein represses the MITF-driven transcription in these cells.
- analysis of the Mitf gene reveals novel conserved domains in human, mouse and Drosophila
- Detection of both partial and whole gene deletions of MITF increase mutation detection in Waardenburg syndrome.
- Microphthalmia-associated transcription factor gene amplification in metastatic melanoma may have a role in patient survival
- link between microphthalmia-associated transcription factor haploinsufficiency and endothelin signaling
- These results show that RAB27A is a new direct transcriptional target of MITF and link MITF to melanosome transport, another key parameter of melanocyte differentiation and skin pigmentation.
- expression of mature miR-137 in melanoma cell lines down-regulates MITF expression
- Data report a three-generation Chinese family with a point mutation in the MITF gene causing Waardenburg syndrome type 2.
- MITF is a major transcriptional regulator of melanoma inhibitor of apoptosis expression in melanomas.
- plays a predominant role in regulation of melanogenesis.
- study identified a novel MITF mutation of IVS4 -1G --> C in a Japanese family with Waardenburg syndrome type II
- BRAF regulates melanoma proliferation through the lineage specific factor MITF
- Brn-2 regulates invasiveness and directly represses Mitf expression.
- MiTF regulates cellular response to reactive oxygen species by regulation of APE-1, and this may provide a mechanism of how MiTF is involved in melanoma carcinogenesis
- expression of miR-182 increases with progression from primary to metastatic melanoma and inversely correlates with FOXO3 and microphthalmia-associated transcription factor levels