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Validated All-in-One™ qPCR Primer for IL1RN(NM_173842.3) Search again
Product ID:
HQP155591
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CRMO2, DIRA, ICIL-1RA, IL-1RN, IL-1ra, IL-1ra3, IL1F3, IL1RA, IRAP, MVCD4
Gene Description:
interleukin 1 receptor antagonist
Target Gene Accession:
NM_173842.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
Gene References into function
- The serum level of IL-1Ra is higher in cicatricial pemphigoid patients in prolonged clinical remission and following intravenous immunogloglobulin therapy, when compared to the pre-IVIg treatment level.
- There were no significant differences in the distributions of the IL-1RN and IL-1B genotpes, allele frequencies or halotypes.
- There is an association between urolithiasis and polymorphism in the IL-1Ra gene.
- Septic shock whole-blood leukocytes and neutrophils (PMNs) selectively maintained production of sIL-1RA after treatment with LPS.
- Interleukin-1 receptor antagonist (IL-1Ra) gene VNTR polymorphism was studied in children with DSM-IV ADHD and their parents to determine the role of brain cytokine activity in the etiopathogenesis of ADHD.
- Slight association of mutations with hypertension.
- results suggest that polymorphisms within IL1RN and IL1L1 themselves or a gene in linkage disequilibrium with IL1RN and IL1L1 predispose to the more severe forms of alopecia areata
- A borderline association was observed between il-1rn and patchy alopecia areata.
- In dengue shock syndrome pts, IL-1Ra was significantly associated with F1+2, TATc (p < 0.04 and p < 0.02, respectively). IL1RA is involved in the onset and regulation of hemostasis.
- Lidocaine inhibits secretion of IL-8 and IL-1beta and stimulates secretion of IL-1 receptor antagonist by epithelial cells.
- IL-1RN*2 homozygotes had a 6.47-fold increased rate of death from sepsis. Insufficient production of IL-1RN might contribute to this higher mortality.
- Interleukin-1 receptor antagonist gene polymorphism in chinese patients with systemic lupus erythematosus.
- There are associations of spontaneous preterm delivery with the fetal carriage of IL1B+3953*1 and IL1RN*2 alleles in African and Hispanic populations, respectively.
- Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis.
- The polymorphism of IL1RN genes 1/2 and 2/2 are associated with the susceptibility of gastric cancer in Chinese.
- IL1RN production is regulated by ligands of the peroxisome proliferator-activated receptor gamma
- Review. The balance between IL-1 & IL-1Ra in local tissues plays an important role in many diseases. An allelic polymorphism has been associated with a variety of human diseases primarily of epithelial & endothelial cell origin.
- Women carrying the A2 allele of the IL-1ra gene showed greater BMD in the lumbar spine and hip.
- important genetic regulator of constitutive, as well as LPS-stimulated, IL-1beta release
- polymorphisms are associated with generalized early onset periodontitis in Japanese
- investigated interleukin polymorphisms in ovarian cancer but did not find any association between common polymorphisms of interleukin 1A, interleukin 1B, and interleukin 1 receptor antagonist and the occurrence of ovarian cancer
- In NIDDM patients, allele 2 carriers had an increased prevalence of CAD that remained significant in a multivariate logistic regression model. Variable number tandem repeat (VNTR) polymorphism in intron 2.
- Investigation of the possible association of a polymorphism in the interleukin-1 receptor antagonist gene with the severity of Plasmodium falciparum malaria in Ghanaian children.
- Pregnant women who are colonized with U. urealyticum during the first trimester have elevated vaginal IL-1ra concentrations and a higher prevalence of the IL-1RN*2 homozygote genotype than do noncolonized women
- a "defective" IL-1ra response to IL-1 may underlie, at least in part, the exaggerated prostaglandin-endoperoxide H synthase (PGHS)-2 induction in orbital fibroblasts
- The polymorphism of IL-1RA seems to be involved in the induction of different solid tumors.
- spontaneous release of IL-8 and IL-1ra by airway neutrophils was significantly higher than that from blood neutrophils in cystic fibrosis
- women with recurrent spontaneous abortion showed a significantly increased frequency of genotypes bearing the rare allele IL1RN*3
- allele 2 of the IL-1ra gene represents a susceptibility factor in the development of carotid atherosclerosis; A gene-dose effect was detected - The homozygous carrier state for allele 2 was associated with greater likelihood of atherosclerosis
- intracellular IL-1Ra1, which is released into the extracellular space when overexpressed under the control of a strong constituitive promoter in transgenic mice has a similar anti-arthritic effect as secreted IL-1Ra
- It was concluded that the lower expression of icIL-1ra in CML marrow nucleated cells might be involved in the evolution of CML.
- serum interleukin-1 receptor antagonist was strongly associated with regional fat distribution, and especially truncal fat mass, both at baseline and during treatment in Cushing's syndrome
- Data suggest that IL-1ra may have a function connected with endothelial cell (EC) growth.
- In multiple sclerosis primary progressive patients, the IL-1beta /IL-1ra ratio was significantly lower than in relapsing-remitting patients.
- Increased serum level of interleukin-1 receptor antagonist is associated with children with Langerhans cell histiocytosis
- polymorphic in women with cervical cancer.
- highly significant ankylosing spondylitis association with markers in the IL1RN gene
- IL-1Ra is not helpful in predicting (POAG) primary open-angle glaucoma in Chinese patients.
- a possible epistatic effect between tumour necrosis factor and IL1RN linked genes for susceptibility to palmoplantar pustulosis
- When analyzed separately, none of the IL1B or IL1RN polymorphisms was associated either with inflammation or restenosis. However, when the IL-1B (-511) and the IL-1RN VNTR genotypes were combined, a highly significant relationship was observed.
- Neither IL-1B-511, IL-1B+3954 nor interleukin-1 receptor antagonist genotypes, allele or carrier frequencies showed significant association with tubal pathology or C.trachomatis post-infection-based tubal pathology.
- The interleukin-1 receptor antagonist (IL-1RA) gene has been shown associated with ulcerative colitis (UC) in some populations. This study aimed to assess the relationship between the IL-1RA polymorphism and UC in a Japanese population.
- Possession by fetus of IL1RN*2 allele is associated with enhanced intraamniotic IL-1beta production. Induction of intra-amniotic proinflammatory immune response might be more likely to lead to preterm labor in fetuses carrying the IL1RN*2 allele.
- Vaginal interleukin-1 receptor antagonist from pregnant women may differ from nonpregnant values; some levels, such as interleukin-6 and interleukin-8, may fluctuate during normal pregnancy. May affect mucosal immunologic responses to genital infection.
- no relationship between the IL-1ra polymorphism and body mass index in Korean women
- IL-1ra attenuated brain edema formation following intracerebral hemorrhage, perhaps by reduction of thrombin-induced brain inflammation.
- A sequencing approach to coding region of human IL1RN gene revealed additional DNA variants, from which a selection was associated asthma. Linkage disequilibrium for human IL1RN gene showed strong linkage disequilibrium for nearly all analyzed SNPs.
- The presence of high amounts of intracellular IL-1Ra1 in human dermal fibroblasts suggests that these cytokines may carry out important function inside cells
- Our results suggest that IL-1Ra and TNF-alpha gene polymorphism is associated with the susceptibility to ischemic stroke in a Korean population
- IL-1 gene cluster polymorphisms may play a significant role in the pathogenesis of osteoarthritis of the hip.
- chronic exposure of human islets to leptin decreased beta cell production of IL-1Ra and induced IL-1beta release from the islet preparation, leading to impaired beta cell function, caspase-3 activation, and apoptosis
- differences in the transcriptional regulation of icIL-1Ra alleles 1 and 2 may be involved in the production of icIL-1Ra protein
- IL-1Ra is mainly produced by adipocytes, rather than the stromal fraction of white adipose tissue, and that IL-1alpha and beta, as well as interferon-beta (IFN-beta), strongly up-regulate the expression and secretion of IL-1Ra
- Our preliminary data suggest that an 86-base pair tandem repeat polymorphism in intron 2 of IL-1 RA does not modulate the onset and cessation of menses in this cohort of Caucasian women.
- HGF and IL-1ra adhesion-dependent release from human blood granulocytes and monocytes involves plasma IgG, complement C3 and beta2 integrin
- IL1B2 and IL1RN*2 genotypes of the IL-1 cluster genes are associated with diabetic nephropathy in Korean patients with type 2 diabetes mellitus
- polymorphisms studied do not play a major role in paranoid schizophrenia pathogenesis in the population investigated.
- A possible relationship of the IL-1RN(VNTR)*2 polymorphism with lower C-reactive protein levels may exist in coronary disease patients.
- IL1RN gene does not appear to play a major role in ankylosing spondylitis genetic susceptibility.
- The polymorphism distributions of IL-1Ra (+8006T/C) and IL-1Ra (VNTR) showed no differences between the essential hypertension group and control group.
- Iindoleamine 2,3-dioxygenase, manganese superoxide dismutase, and interleukin-1 receptor antagonist protein transferred to isolated NOD mouse donor islets protect islet grafts from diabetogenic T cells.
- OxLDL exposure reduces the expression of IL1RN.
- strong and early expression of interleukin-1 receptor antagonist(IL-1Ra) proves to be non-protective due to the robust expression of airway agonist interleukin-1beta seen by day 5 in premature infants who develop bronchopulmonary dysplasia (BPD)
- No correlation of polymorphisms with gastric cancer.
- The genotype of interleukin-1 receptor antagonist seems to be associated with early-stage gastric cancer.
- IL-1Ra(-/-) mice failed to induce mRNA expression of cholesterol 7alpha-hydroxylase, the rate-limiting enzyme in bile acid synthesis, with concurrent up-regulation of small heterodimer partner 1 mRNA expression, needed for cholesterol homeostasis
- data indicate that H. pylori infection and IL-1RN*2 synergistically determine susceptibility to duodenal ulcer
- IL-1ra gene polymorphism is closely associated with race, but does not influence the susceptibility of alcoholic liver disease.
- polymorphisms in chronic obstructive pulmonary disease patients
- The protein encoded by the IL1RN gene may be involved in susceptibility to alcoholism in Spanish men, probably through a different pathway from that involved in the regulation of the inflammatory response.
- Variation in the IL-1 receptor antagonist gene and IL-1 beta genes individually does not play a role in susceptibility to recurrent miscarriage.
- Co-expression of icIL-1Ra1 did not antagonize this effect, indicating that intracellular effects of preIL-1alpha are not necessarily susceptible to inhibition by icIL-1Ra1
- epistatic interrelationship between interleukin 1, beta-511 and interleukin 1, beta catabolin confers protection against gastric cancer in low-risk Italian population
- Two polymorphisms within the IL-1 gene cluster are associated with ESRD independent of race
- IL-1RN gene might contribute to the ventricular volumetric changes observed in schizophrenic patients
- Anion competition for the interleukin-1 receptor antagonist (IL-1ra) cationic site suppresses IL-1ra aggregation via interference with its self-association pathway.
- IL1B -31C>T and IL1RA VNTR polymorphisms do not play a crucial role in susceptibility or resistance to cerebral malaria.
- Association seen between common haplotype in the IL1RN gene and prostate cancer in Swedish population; supports role of inflammation in prostate cancer development
- IL-1Ra gene polymorphism was found in patients diagnosed with crohn disease living in India.
- results indicate that individuals homozygous for the IL1RN*1 allele and carrying the IL1B-31T allele had increased risk of non-small cell lung cancer; findings support the significance of IL1 gene cluster polymorphisms and risk of lung cancer
- an IL-1Ra polymorphism has a role in colorectal carcinogenesis
- IL-1Ra, Bcl-2, and iNOS are upregulated and counter the proinflammatory and proapoptotic effects of ischemia-reperfusion
- IL1RN has a role in determining susceptibility to rheumatoid arthritis in the Spanish population.
- Exerts intracellular functions regulating effect of N-terminal IL-1alpha propiece on movement of ECV304 tumor cells.
- Increased levels of cord IL-1ra levels are associated with neonatal morbidity and adverse outcome in preterm infants
- substance P, epinephrine, and norepinephrine are not involved in mediating peripheral inflammation following psychosocial stress, at least with respect to interleukin-1 receptor antagonist
- results suggest that IL-1RN2 allele positivity is associated with periodontal disease in a Turkish population
- The association between the interleukin-1 polymorphisms and gastric cancer risk depends on the family history of gastric carcinoma in the study population.
- Novel functions for icIL-1ra, which might be relevant to the genesis of fibrotic diseases such as systemic sclerosis were demonstrated.
- Glucan phosphate raised the LPS- & the TSST-1-induced DNA binding of NFkappaB, NFIL-6 & NFAT, leading to a synergistic increase of IL-1RA. Complex regulation of the IL-1RA gene via multiple promoter binding sites can be modulated by a beta-1-->3-D-glucan
- Allele frequencies did not vary statistically significantly among women with polycystic ovary syndrome(PCOS) and healthy controls or within the PCOS group with respect to their clinical characteristics.
- Increased circulating levels of interleukin 1 receptor antagonist is associated with Hepatitis C virus positive patients and with those affected also by non-Hodgkin's lymphoma with or without cryoglobulinemia syndrome
- IL-1beta and IL-1Ra haplotype influences the impact of allograft outcome in renal transplant patients.
- IL-1Ra intron 2 polymorphism plays a prominent role among the IL-1 gene cluster with respect to bladder carcinogenesis.
- IL-1RA might be a candidate mediator to exert as an anti-apoptotic molecule during the interaction between human limbal epithelial cells and intact human amniotic membrane.
- IL-1Ra genetic polymorphism may contribute to the variation in postoperative morphine consumption.
- analysis of the NFKB1 protein polymorphism interactions with CARD15/NOD2, IKBL, and IL-1RN genes
- non-fat cells in human adipose tissue contribute to most of the release of interleukin 1 receptor antagonist seen during primary culture of adipose tissue explants from obese women
- Carriers of the IL-1-RA appeared to have an increased risk of stroke in association with a febrile episode prior to strokes.
- The results of this study provide evidence of an association between the IL1RN*long allele and Rheumatoid Arthritis (RA), the strongest association being observed in RA patients with an aggressive disease resistant to methotrexate treatment.
- co-expression of vascular endothelial growth factor and interleukin-1 receptor antagonist can improve the outcome of islet transplantation better than either gene alone
- the carriage of IL-1R receptor antagonist alleles 2, 4, 6 may not play any role in the development of HBV infection
- Patients with at least one copy of the IL1RN*2 allele had increased risk of death during the first week, and patients homozygotic for this allele had increased risk of death within the first month after stroke
- There is a significant association between an intron 2 genetic polymorphism of IL-1Ra and susceptibility to brucellosis.
- In a meta-analysis, the overall associations between IL-1RN proinflammatory polymorphisms and gastric cancer were null but several studies showed an association. The sources of this variation are unclear.
- interleukin-1beta (-511C/T) and IL-1RN (VNTR) polymorphisms are significantly associated with increased risk of Type 2 diabetes mellitus as well as associated complications in North Indians
- Maternal carriage of at least 1 copy of the IL-1RN allele 2 appears to be associated with increased risk of preterm birth.
- Results show that IL1RN and its isoforms were involved in the pathogenesis of systemic lupus erythematosus.
- The present results demonstrate that PI3Ks are involved in the inhibition of IL-1beta secretion and in the induction of sIL-1Ra production in human blood monocytes.
- Results demonstrate the association of the IL-1Ra allele 2 with faster progression to end-stage renal disease.
- Interleukin 1 receptor antagonist gene polymorphisms are associated with gastric cancer
- Coexpression of hVEGF and hIL-1Ra suppressed nitric oxide production, total caspases, apoptosis, and necrosis in the presence of inflammatory cytokine cocktail consisting of IL-1beta, TNFalpha, and IFNgamma.
- Decreased levels of IRAP in patients with endometriosis and disease-related dysmenorrhea may play an important role in the pathogenesis of this disease.
- data show that the IL-1RN VNTR genotype was not associated with bacterial vaginosis although the rare allele 3 showed a trend towards protection in non-pregnant Italian women
- Allele 2 of IL1RN, present in nearly one-quarter of stroke patients, may contribute to genetic risk for ischemic stroke and confirm the previously identified association with cerebrovascular disease
- the data suggest an essentially two-state equilibrium denaturation mechanism with small, but detectable structural changes within the pretransition region.
- a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection
- gene polymorphisms could have an active role in the pathogenesis of gingivitis in Caucasian children and IL-1RN*2 allele could be a protective marker against gingivitis
- A fusion protein of recombinant IL-1 receptor antagonist and Il-1RA showed attenuated expression of pro-inflammatory cytokines.
- The finding suggests that the IL-1 Ra gene polymorphism is implicated in the pathophysiology of childhood Immune thrombocytopenic purpura (ITP).
- study does not support the role of common genetic variation at MIC1 and IL1RN in prostate cancer susceptibility
- association of polymorphisms in the IL-1Ra gene and IL-1 beta gene with the susceptibility to rheumatoid arthritis appears to be significantly affected by gender
- TNF-alpha, IL-1beta and IL-1Ra are produced after selective activation of mast cells in rheumatoid synovial tissue
- results of the present study suggest that the IL1 gene complex does not play a major role in conferring susceptibility to schizophrenia in the Japanese population
- IL-1beta -511C/T and IL-1 RN 86 bp VNTR do not contribute to the aetiology of essential hypertension in the Pakistani Pathan population investigated here
- In traumatic brain injury, the ability of patients to mount a response to receptor antagonist interleukin (IL)-1ra, as measured in cerebrospinal fluid, strongly correlates with the neurological outcome.
- study suggests that the IL1RN VNTR, IL1A+4845, IL1B+3953 genes polymorphisms are not genetic markers of susceptibility to knee osteoarthritis in Turkish patients & are unrelated to clinical, radiological & laboratory characteristics of knee osteoarthriti
- The chronic blockade of IL-1 signalling in the brain was associated with an atrophic phenotype of the brain, and with modified levels of APP and PS1.
- IL1RN VNTR and the IKBL + 738T > C gene polymorphisms are not risk factors for myocardial infarct in Caucasians with type 2 diabetes
- IL-1B +3954 and IL-1RN genetic polymorphisms are associated with a significantly increased risk of RA in this Chinese population
- The IL-1RN*2 allele is a susceptibility marker for ankylosing spondylitis in the Indian population but does not influence disease phenotype.
- Biodegradable microspheres represent an efficient system for sustaining recombinant IL-1Ra delivery and improving its therapeutic efficacy.
- Report conformation and side chain environments of recombinant IL-1ra probed by raman, raman optical activity, and UV-resonance Raman spectroscopy.
- Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma.
- Our data provide evidence for an altered ratio of IL-1/IL-1ra in DCM patients. This dysregulation may contribute to pathogenesis and/or progression of heart disease by modulating the otherwise balanced IL-1-mediated functions in cardiovascular cells.
- Genetic polymorphisms are not associated with the development and clinical features of adult-onset Still's disease.
- the IL-1 gene cluster may harbour susceptibility genes for AITDs and GD pathogenesis in the Tunisian population
- Interleukin-1 receptor antagonist is the earliest sensitive marker of anti-inflammatory response to enteral immunonutrition in malnourished patients after pancreaticoduodenectomy.
- IL1-RA polymorphism is associated with cervical cancer.
- For T-cell non-Hodgkins Lymphoma, homozygosis for the IL1RN rs454078 T-allele was associated with a 4.5-fold elevated risk
- In atrophic ody gastritis patients IL-1RN polymorphisms does not appear to be associated either with specific clinical, biochemical or histological features or with the development of gastric neoplastic lesions at long-term follow-up.
- The aim of the present study was to investigate whether variations in the interleukin-1 receptor antagonist (IL-1RN) were associated with structural brain characteristics of 73 minimally medicated first-episode non-affective psychotic patients.
- A combination of IL-1beta and IL-1RA associations exhibiting gene-gene interaction further substantiates the finding of risk.
- IL-1Ra serum levels exhibit marked interindividual gender-based variation in type 2 diabetics with high intraindividual consistency.
- glycosylated IL-1ra contained high mannose glycoforms that ranged from Man(9)GlcNAc(2) to Man(14)GlcNAc(2).
- Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of metabolic syndrome
- IL-1RN gene polymorphism has no association with acute coronary syndrome, but the allele 1 (C) of IL-1B (-511) may be a risk factor for susceptibility to USAP in the Turkish population
- the association of IL-1RN +2018 C with reduced susceptibility to CP in the Japanese
- Data show that low IL-1 RA levels in ascites are associated with a significant improvement in postoperative and progression-free ovarian cancer survival, and suggest that IL-1 RA shows a prognostic relevance in ovarian cancer.
- IL-1RN*2 allele carriage is associated with a poor prognosis of achieving a pregnancy after IVF.
- IL-1RN*2 and IL-1beta -511*T in various combinations of genotypes and haplotypes are associated with higher susceptibility for cervical cancer.
- There was a statistically significant gender difference (p=0.018) in correlation between quantitative insulin sensitivity check index anad IL-1 Ra levels.
- subjects with IL-1 beta*T-IL-1RN*1 (T1) haplotype had lower risk for middle third tumor location of EC in a northern Indian population
- no significant difference in IL1Ra polymorphisms between patients with and without placental abruption.
- Common functional polymorphisms of the IL1RN gene are associated with several markers of systemic inflammation.
- IL-1Ra gene polymorphism is associated with the risk of BPH
- Our findings provide further evidence of a possible role of polymorphisms of the IL-1 gene cluster in disease severity in RA.
- Down-regulation in the release of the pro-inflammatory cytokine IL-1beta and the up-regulation of its antagonist (IL-1Ra) may be a part of the inflammatory response to infection in human term, but not preterm, placentae.
- Type I IFN-induced IL1RA expression in hepatocytes is mediated by activating STAT6 through the formation of STAT2:STAT6 heterodimer.
- Report IL1RN gene polymorphisms in gastric cancer cases' and controls' family members from Chinese areas at high cancer prevalence.
- Recombinant human interleukin-1 receptor antagonist attenuates the severity of spinal cord ischemic injury in rabbits.
- Cardiomyocytes in health and infarcted myocardium represent a major source of IL-1ra in vivo.
- Detection of receptor antagonist tandem repeat polymorphisms among 21 HLA identical renal transplant recipient and donor pairs.
- High endogenous IL-1Ra (interleukin 1 receptor antagonist) /IL-1beta ratio occurs in synovial fluid from knee osteoarthritis; it does not correlate with pain or Lequesne index
- Expression of IL-1Ra was detected in the epithelial cells in five cases, and in the endothelial cells and fibroblasts in three cases of keratocystic odontogenic tumors.
- To test whether polymorphisms in IL-1, NF-KB, FAS, and FASL genes are associated with risk of silicosis
- Interleukin-1 receptor antagonist allele 2 is associated with a reduced time interval from labor induction to delivery.
- no significant differences were found when the frequency of IL-1RN 2 polymorphisms were compared between fertile control couples and couples experiencing recurrent pregnancy loss
- These results suggest that the interleukin-1 receptor antagonist IL-1RN*2 allele might represent a factor of susceptibility to OA; however, no correlation between this allele and the markers of cartilage degradation was found.
- five genes (TNFSF10/TRAIL, IL1RN, IFI27, GZMB, and CCR5) were upregulated and three genes (CLK1, TNFAIP3 and BTG1) were downregulated in at least three out of four subpopulations during acute GVHD.
- The IL1RA(interleukin 1 receptor antagonist) +2018C allele is associated with a decreased risk of osteolysis after Total hip replacement
- In children with community-acquired pneumonia, absence of the A1 allele at the interleukin-1 receptor antagonist intron 2 polymorphic site is associated with increased risk for more severe lung injury
- Individuals with 1/C and 2/C haplotypes of IL-1RN VNTR and -511IL-1B C --> T polymorphisms were more susceptible to develop gallbladder cancer with gallstones compared to healthy controls in north India.
- IL-1Ra(interleukin 1 receptor antagonist) VNTR polymorphisms are not associated with the development of amyloid in familial Mediterranean fever patients
- polymorphisms of interleukin-1 receptor antagonist gene in systemic oncogenesis: significant etiopathologic connections
- Polymorphisms related to TNF-alpha and IL-1Ra genes may be considered genetic markers for Type 1 diabetes (T1D) among Egyptians.
- upregulated expression in follicular phase of menstrual cycle