|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for IL1R1(NM_001320978.2) Search again
Product ID:
HQP155575
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CD121A, CRMO3, D2S1473, IL-1R-alpha, IL-1RT1, IL1R, IL1RA, P80
Gene Description:
interleukin 1 receptor type 1
Target Gene Accession:
NM_001320978.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq].
Gene References into function
- Heparins (unfractionated heparin, UFH and low molecular weight heparin certoparin) had no effect on the release of IL-1ra, IL-10, and IL-12p40 from neutrophils or peripheral blood mononuclear cells.
- Carriage of IL1beta and IL1RN*2, together with non-carriage of TNF2 is associated with increased susceptibility, but not with a prognosis of IgAN.
- Carriage of ILRN*2 alleles influences disease severity rather than susceptibility.
- IL-1 receptor has a role in the pathway linking static compression to reduced proteoglycan synthesis
- A decrease in interleukin-1 receptor antagonist expression in the prefrontal cortex of schizophrenic patients.
- high allele frequency of the IL1RN*2 allele may affect disease susceptibility in childhood nephrotic syndrome
- IL-1RA gene polymorphism is not responsible for specific clinical characteristics in RA and SLE but that IL-1RN*2 is relevant in the susceptibility to RA.
- There is an association between polymorphisms of the promoter region -511C/T of IL-1B and IL-1RN intron 2 and chronic hepatitis B virus infection
- Sixteen SNPs were identified through a 9643 bp sequencing of IL-1R1 gene. Four were in 5' flank region, four in intron region, one in coding region, and seven in 3' untranslated region.
- Data show that Exip, but not p38alpha, binds to Toll interacting protein, which is involved in interleukin-1 (IL-1) signaling pathway, and impaired NF-kappaB activity.
- the dysregulation of IL-1/IL-1-R system relates to immunological dysfunction in endometriosis
- SIGIRR inhibits IL-1R and TLR4-mediated signaling through different mechanisms
- Our findings indicate that the VDR FokI polymorphism and several VDR and IL-1-R1 haplotypes are associated with susceptibility to T1DM in the Dalmatian population.
- data describe percentage of bone marrow cells expressing receptors for interleukin-1, platelet-derived growth factor, fibroblast growth factor, transforming growth factor-beta, epidermal growth factor and c-Fos and c-Myc in untreated lung & breast cancer
- Rac1 facilitated the recruitment of Nox2 into the endosomal compartment and subsequent redox-dependent recruitment of TRAF6 to the MyD88/IL-1R1 complex.
- icIL-1ra1 does not act at an intracellular level to alter IL-1 mediated signalling, and is effective in inhibiting IL-1 responses only when released in an ATP-dependent and cell type specific manner
- Distributions of single-base polymorphisms of the human IL-1RI gene were evaluated and a C-->A transition in exon 1C showed protective effect against endometriosis in heterozygotes.
- Our study showed an imbalance in the expression of IL1R1 and IL1R2 in eutopic, and particularly in ectopic, endometrial tissues of women with endometriosis
- Conformational stability of rhIL1ra was monitored by equilibrium urea denaturation, and thermodynamic parameters of unfolding; conformational stability, monitored using the Cm value, has an effect on oxidation rates of buried methionines
- Abnormal interleukin 1 receptor types I and II gene expression in eutopic and ectopic endometrial tissues of women with endometriosis.
- rheumatic heart disease cases showed a significantly higher frequency of homozygous genotypes of IL-1Ra A1/A1. Cases with mitral valve disease showed higher frequencies of genotype IL-1Ra(VNTR) A1/A1.
- This study shows an increase in gene and protein production for the IL-1 receptor type I in degenerate intervertebral discs.
- results showed that there was a gender difference in IL-1Ra gene polymorphism expressed by a higher incidence of IL1RN*1/IL1RN*1 homozygotes and a lower occurrence of IL1RN*1/IL1RN*2 heterozygotes in men compared with women
- The expression of the IL-1 receptor, a known regulator of SREBP-2, was also elevated after exercise.
- polymorphism is not associated with the presence of pulmonary aspergillosis infection; but in combination with IL1a and IL1b genotypes may predict disease susceptibility
- Mild or intensive immunoreactivity for IL-1RI was observed in the epithelial cells in all cases, and in the endothelial cells and fibroblasts in five cases of keratocystic odontogenic tumors.
- IL-6 and IL-1Ra polymorphisms can be considered genetic markers for bronchial asthma susceptibility and/or severity among Egyptian children.
- TRAF6 and interleukin receptor-associated kinase 2 are novel binding partners for PS1, and IL-1R1 is a new substrate for presenilin-dependent gamma-secretase cleavage