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Validated All-in-One™ qPCR Primer for GRM2(NM_000839.5) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Gene References into function
- Ser-148 and Arg-183 may be important for the 3D structure and/or are involved in closure of the domain. Asp-146 is involved in differential binding properties of mGlur2.
- Mapped to Chromosome 3p21.1 - p21.2 and has 5 exons ranging from 74 - 1076 bp.
- The presynaptic group 2 metabotropic glutamate receptor reduces stimulated and spontaneous transmitter release in the dentate gyrus.
- Reduction of mGluR2 immunopositive product in the stratum lacunosum moleculare of hippocampal CA1 is a consequence of neuronal loss in either the entorhinal cortex or CA1 area of the hippocampus.
- Stimulation of glial mGluR2 through mediators present in the cerebrospinal fluid may contribute to glial proliferation and astrogliosis in amyotrophic lateral sclerosis.
- Authors have identified and synthesized a brain penetrant propanoic acid as an allosteric potentiator of the metabotropic glutamate receptor 2.
- The objective of this study was to assess the effects of the mGlu2/3 receptor agonist LY404039 (LY) on operant EtOH self-administration during alcohol seeking pavlovian spontaneous recovery, alcohol relapse, and maintenance responding for alcohol.
- In post-mortem human brain from untreated schizophrenic subjects, the 2AR is upregulated and the mGluR2 is downregulated, a pattern that could predispose to psychosis
- The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia.
- findings show that the activation of mGluR2 leads to the activation of extracellular signal-related kinase pathways