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Validated All-in-One™ qPCR Primer for GRIN2B(NM_000834.5) Search again
Product ID:
HQP154634
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
DEE27, EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3
Gene Description:
glutamate ionotropic receptor NMDA type subunit 2B
Target Gene Accession:
NM_000834.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq].
Gene References into function
- NMDA receptor subunit 2B (GRIN2B) genetic variants and psychopathology and clozapine response in schizophrenia
- hypothesis that the allelic variant (C2664T) of the NR2b confers susceptibility to AD .
- It is unlikely that the GRIN2B C2664T polymorphism plays a substantial role in conferring susceptibility to Parkinson's disease in the Chinese population.
- The levels of Nr2B mRNA are decreased in Alzheimer disease hippocampus and entorhinal cortex compared to controls.
- identification of a novel variant of the human gene promoter region and its possible association with schizophrenia
- The results show that GRIN2B genetic variations are not a major risk factor for treatment-refractory schizophrenic patients, but may influence the effect of clozapine during treatment.
- human cerebral endothelial cells express the message and protein for NMDA receptors.
- Variants in NMDAR genes are associated with alcoholism and related traits.
- NR2B was located in the midpiece of sperm, whereas GLT1 mainly existed in the head
- Increased coassembly of NR2B and NR1 with PSD-95 may underlie one of the cellular mechanisms that contributes to in situ increased hyperexcitability, leading to seizure generation in focal cortical dysplasia.
- These results provide evidence that GRIN2B may be associated with susceptibility to OCD.
- Reviews the role of altered structure and function of NMDA receptors after ethanol exposure and summarizes the recent data about the activity of NR2B subunit selective NMDA receptor antagonists in model systems related to alcoholism.
- results suggest that GRIN2B single nucleotide polymorphisms might be linked with susceptibility to schizophrenia
- NR2B subtypes mainly expressed in the striatum, may influence the variability in age of onset of Huntington disease.
- the combined effects of the polymorphisms in the GRIN1 and GRIN2B genes might be involved in the etiology of schizophrenia.
- novel mechanism for Ca2+-dependent negative-feedback regulation of NR2B-containing NMDARs in a CaMKII activity- and autophosphorylation-dependent manner that may modulate NMDAR-mediated synaptic plasticity
- These results demonstrate that human T lymphocytes express the NR2B subunit of NMDA receptors, which are functionally active in controlling cell activation.
- The genetic findings suggest a role for GRIN2B in schizophrenia and bipolar disorder.
- Results describe the successful replacement of murine N-methyl-d-aspartate receptor (NR)2B gene function by "knocking-in" a chimeric human NR2A/B cDNA containing the minimal domain abolishing ifenprodil binding into the endogenous NR2B locus.
- These findings suggest new candidate SNPs(rs1806201) in GRIN2B for studying the genetic susceptibility to alcoholism.
- data suggest an association between variations in the GRIN2B subunit gene and ADHD as measured categorically or as a quantitatively distributed trait.
- The results show evidence of a statistically significant association for GRIN2B. The association seems weaker, but nonetheless interesting
- the three amino acid tail following the TM4 region of the N-methyl-D-aspartate receptor (NR) 2 subunits is sufficient to overcome endoplasmic reticulum retention of NR1-1a subunit
- postsynaptic density-93 and N-methyl-D-aspartate receptors subunits 2B mRNA are upregulated in temporal lobe tissue of epilepsy
- NR2A and NR2B receptor gene variations modify age at onset in Huntington disease in a sex-specific manner.
- NMDAR2B methylation is a common and important biologically relevant event in gastric cancer progression
- genetic variations in the human GRIN2B gene probably do not play a major role in susceptibility to, or severity of Tardive dyskinesia
- Laser capture microdissection combined with quantitative PCR was used to examine the expression of AMPA (GRIA1-4) and NMDA (GRIN1, 2A and 2B) subunit mRNA levels in Layer II/III and Layer V pyramidal cells
- The interaction between NR2B subunit and Mind bomb-2 reveal a possible mechanism for the regulation of NMDAR function involving both phosphorylation and ubiquitination.
- results on chromosome 12p support GRIN2B as a candidate gene for bipolar disorder that needs further investigation
- the synaptic NMDA receptor extracellular signal-regulated kinase activation pathway is coupled to both NR2A and NR2B containing receptors
- GRIN2B gene is associated with Alzheimer's disease.
- Data show that expression of NMDA receptor NR1, NR2A, and NR2B subunits is significantly lower in brains of cirrhotic alcoholics than in the corresponding areas in both controls and alcoholics without co-morbid disease.
- An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.
- A comparison of the molecular bases for NR1/NR2B receptor inhibition versus immobilizing activities of volatile aromatic anesthetics.