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Validated All-in-One™ qPCR Primer for GRIN1(NM_007327.4) Search again
Product ID:
HQP154630
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
DEE101, GluN1, MRD8, NDHMSD, NDHMSR, NMD-R1, NMDA1, NMDAR1, NR1
Gene Description:
glutamate ionotropic receptor NMDA type subunit 1
Target Gene Accession:
NM_007327.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel.
Gene References into function
- the rapidly and slowly degrading pools mainly consisted of the NR1 splice variants NR1-4a and NR1-2a. deglycosylation by endoglycosidase H indicated the presence of an immature form of NR1 that was retained in the endoplasmic reticulum.
- molecular interaction between PSD-95 and nmda receptors: the effct of the NR1 splice variant on channel gating.
- Alteration of branch site consensus sequence and enhanced pre-mRNA splicing of an NMDAR1 intron not associated with schizophrenia.
- involvement of the GRIN1 in the pathogenesis of bipolar disorder
- Tested the association of two silent polymorphisms, a G/C substitution localized on the 5' UTR and an A/G substitution localized in exon 6, with schizophrenia and found no significant results. Haplotype analyses showed a borderline significant result.
- human cerebral endothelial cells express the message and protein for NMDA receptors.
- Variants in NMDAR genes are associated with alcoholism and related traits.
- SIDS infants had increased mRNA in 6 nuclei of the mid-medulla, while protein was increased in the dorsal motor nucleus of the vagus (p = 0.04) and decreased in the nucleus of the spinal trigeminal tract (p = 0.03).
- disulfide bridging and structural integrity within the NR1 N-terminal domain is requisite for cell surface N-methyl-D-aspartate receptor expression
- the NR1 promoter is positively regulated by NF-kappaB site during neuronal differentiation by interacting with Sp3/Sp1
- A significant decrease in the phosphorylation level at serine 897 (S897) of the NMDA receptor type 1 (NR1) subunit was found in brains from patients with schizophrenia
- Absolute levels of the eight NR1 transcripts by quantitative internally standardized RT-PCR assay were measured; expression was strongly attenuated in susceptible regions of Alzheimer's disease brain
- Increased coassembly of NR1 and NR2B with PSD-95 may underlie one of the cellular mechanisms that contributes to in situ increased hyperexcitability, leading to seizure generation in focal cortical dysplasia.
- NMDA receptor may play a role in the regulation of keratinocyte growth and differentiation
- NMDA receptors are expressed in human epidermis under physiological conditions especially in stratum granulosum. Their reduced expression within parakeratotic epidermis in psoriasis vulgaris may be evidence of impaired intracellular calcium influx.
- arginine 260 is necessary for both tPA-induced cleavage of the ATD of NR1 and tPA-induced potentiation of NMDA receptor signaling
- A tendency to a decrease in the density of the NR1 upper band below control values is found in superior temporal cortex of bipolar and depressed patients, but not schizophrenics.
- Genes for the NMDAR1 subunit is not frequently involved in the development of schizophrenia in the German population.
- the combined effects of the polymorphisms in the GRIN1 and GRIN2B genes might be involved in the etiology of schizophrenia.
- the conformation of NR1 subunit homodimers is affected by the partner NR2 subunits during the formation of heteromeric receptor complexes
- These results suggest that NR1 may play a role in carcinogenicity and cell death associated with one-electron reductions.
- Significant reductions were found in relative NMDA receptor binding in left hippocampal medication-free, but not antipsychotic-treated, schizophrenic patients.
- These results demonstrate that human T lymphocytes express the NR1 subunit of NMDA receptors, which are functionally active in controlling cell activation.
- ApoEr2 can form a multiprotein complex with NMDA receptor subunits and PSD95
- NR3 nmda receptor subunits induce plasticity in NR1 with respect to subunit assembly and ligand binding/channel coupling that is unique among ligand-gated ion channel subunits.
- the three amino acid tail following the TM4 region of the N-methyl-D-aspartate receptor (NR) 2 subunits is sufficient to overcome endoplasmic reticulum retention of NR1-1a subunit
- Data show that SNPs in GRIN1 gene were related to the bipolar disorder. The results confirm that the GRIN1 gene confers susceptibility to bipolar disorder.
- Significant associations in single-marker and haplotype-based analyses pf variants and schiophrenia with depressive symptoms.
- the synaptic NMDA receptor extracellular signal-regulated kinase activation pathway is coupled to both NR2A and NR2B containing receptors
- deletion of the C terminus of the mGlu5a receptor abolishes both its interaction with the NMDA receptor and reciprocal inhibition of the receptors
- NR1 expression begins low prenatally, peaks in adolescence, yet remains high throughout life, suggesting lifelong importance of NMDAR function
- MMP-7 cleaves the NR1 subunit of the N-methyl-d-aspartate (NMDA) receptor to generate an N-terminal fragment of approximately 65 kDa
- NR1-1a (D732E)/NR2A and NR1-1a (D723A)/NR2A trafficked as efficiently as NR1-1a/NR2A, there was a 90% decrease in surface expression for NR1-1a (D732A)/NR2A.
- Data show that expression of NMDA receptor NR1, NR2A, and NR2B subunits is significantly lower in brains of cirrhotic alcoholics than in the corresponding areas in both controls and alcoholics without co-morbid disease.
- A comparison of the molecular bases for NR1/NR2B receptor inhibition versus immobilizing activities of volatile aromatic anesthetics.