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Validated All-in-One™ qPCR Primer for GLRX(NM_001243658.2) Search again
Product ID:
HQP154378
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
GRX, GRX1
Gene Description:
glutaredoxin
Target Gene Accession:
NM_001243658.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- Glutaredoxin-dependent peroxiredoxin from poplar: protein-protein interaction and catalytic mechanism
- Results suggest that glutaredoxin plays an important role during implantation, while Trx levels remained constant during the secretory phase.
- role of GRX in oxidative stress-induced signaling and cytotoxicity in glucose-deprived human cancer cells
- facilitates GS-radical scavenging and S-glutathionylation of redox signal mediators, consistent with a critical role in redox signal transduction and cellular regulation
- role in metabolic oxidative stress-induced activation of apoptosis signal-regulating kinase 1
- secretion of Grx1 and its presence in plasma suggests extracellular functions as found for mammalian thioredoxin 1
- Lung cells can synthesize Grx1 mRNA and protein. Grx1 is expressed in alveolar macrophages of healthy lung.
- Grx1(as) cDNA is an alternatively spliced human Grx1 cDNA and the Grx1(as) 3'-untranslated region may have a role in stabilizing mRNA
- Abeta neurotoxicity might be mediated by oxidation of GRX1 or TRX1 and subsequent activation of the ASK1 cascade.
- We propose that GRX1 is essential for ATPase function and catalyses either the reduction of intramolecular disulphide bonds or the deglutathionylation of the cysteine residues within the CxxC motifs to facilitate copper-binding for subsequent transport.
- GRX plays an important role in PDGF-BB-dependent cell proliferation by regulating the redox state of LMW-PTP
- Grx1 is a potential redox modulatory protein regulating the intracellular as well as extracellular homeostasis of glutathionylated proteins and GSH in human lung.
- A novel mechanism of caspase-3 regulation by glutaredoxin is demonstrated in tumor necrosis factor-alpha-induced apoptosis.
- In this review, reversible glutathiolation of procaspase-3 by glutaredoxin provides further mechanistic insight into the role of reactive oxygen species in TNF-alpha-induced apoptosis.
- The results of this study implicate a role of Glrx1 in cardioprotection and redox signaling of the ischemic myocardium.
- Deglutathionylation of IRF3 is necessary for efficient interaction of IRF3 with CREBBP.
- downregulation of Grx1 leads to mitochondrial dysfunction through oxidative modification of the outer membrane protein, VDAC, providing support for the critical role of Grx1 in maintenance of mitochondrial membrane potential