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Validated All-in-One™ qPCR Primer for GATA4(NM_002052.5) Search again
Product ID:
HQP154212
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ASD2, TACHD, TOF, VSD1
Gene Description:
GATA binding protein 4
Target Gene Accession:
NM_002052.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes.
Gene References into function
- GATA-4 and GATA-6 mRNAs are readily detectable from gestational week 19 in human adrenal cortex.
- role in trans-activation of bone morphogenetic protein 4 and regulation of mammalian organogenesis
- In postnatal ovary, granulosa cells of growing follicles express FOG-2, partially overlapping with expression of mullerian-inhibiting substance. Important role for FOG-2 and GATA transcription factors in developing ovary.
- Nkx-2.5 and GATA-4 play prime roles in Dio2 gene regulation in the human heart and suggests that it is their synergistic action in humans that causes the differential expression of the cardiac Dio2 gene between humans and rats.
- results implicate GATA4 as a genetic cause of human cardiac septal defects, perhaps through its interaction with TBX5
- Wild-type SF1 but not SF1 G35E is a potent transactvator in GAGA4-expressing cells. Results strengthen the importance of a GATA-4/SF-1 cooperation for MIS transcription; disruption of this synergism might lead to abnormal sex differentiation.
- GATA-4 is critical for transcription of the erythropoietin (Epo) gene in hepatocytes and may contribute to the switch in the site of Epo gene expression from the fetal liver to the adult kidney
- in colorectal cancer and gastric cancer promoter hypermethylation and transcriptional silencing are frequent for GATA-4 and -5
- plays a transactivator role in the regulation of the transcription of the microsomal epoxide hydrolase gene (EPHX1)
- transcription factors GATA4 and YY1 are involved in the regulation of FcgammaRIIb expression, and that the expression variants of FcgammaRIIb lead to altered cell signaling, which may contribute to autoimmune pathogenesis in humans.
- A novel atrial septal defect causative GATA4 mutation in a Japanese family.
- GATA4 is a SUMO-1-targeted transcription factor and together with PIAS1 is a potent regulator of cardiac gene activity
- optimal claudin-2 expression in the gut relies on the presence of GATA-4, suggesting a role for this factor in intestinal regionalization
- Hypermethylation of the GATA4 is associated with lung cancer
- NKX2.5 inhibits myocyte differentiation and myotube formation, and up-regulates Gata4 and Tbx5 expression
- Steroidogenically active human adrenocortical cells were weakly positive for GATA-4, whereas steroidogenically inactive cells were totally GATA-4 negative. In contrast, both cell lines expressed GATA-6.
- GATA-4 detected in ovarian GCTs has retained normal function
- expression of GATA-4 and GATA-6 is up-regulated prior to the transcriptional activation of Nkx 2.5 during cardiogenesis
- Aggressive granulosa cell tumors(GCTs) retain high GATA-4 expression, whereas larger tumors lose proliferation-suppressing anti-Mullerian hormone expression. High GATA-4 expression in GCTs may serve as marker of poor prognosis.
- Methylation of GATA-4 was associated with ovarian carcinogenesis
- a GATA4 mutation may have a role in Tetralogy of Fallot
- Altered histone modification of the promoter loci is one mechanism responsible for the silencing of GATA transcription factors.
- Frequent silencing of GATA-4 and GATA-5 in human esophageal neoplasia is associated with gene promoter hypermethylation.
- Data show that Oct-4, Rex-1, and Gata-4 expression in human mesenchymal stem cells increases cell differentiation efficiency but not hTERT expression.
- GATA4 mutations are relatively rare among congenital heart disease patients.
- TGF-beta signaling regulates gut epithelial gene expression by targeting GATA4.
- GATA4 mutations that result in deficits in transactivation ability are consistently associated with congenital heart disease suggesting that normal transactivation properties of GATA4 are required for proper cardiac development.
- Cooperative interaction between HNFA4 and GATA4 and GATA6 regulates ABCG5 and ABCG8.
- analysis of the nuclear shuttling pathways of GATA-4 that represent an additional mechanism of gene regulation
- Tbx18 interacts with Gata4 and Nkx2-5 and competes Tbx5-mediated activation of the cardiac Natriuretic peptide precursor type a-promoter. Tbx18 down-regulates Tbx6-activated Delta-like 1 expression in the somitic mesoderm in vivo
- somatic GATA4 mutations in the 3'-UTR may provide an additional molecular rationale for congenital heart disease
- These data establish the phenotypic spectrum of heterozygous Gata4 mutation in mice, and suggest that heterozygous GATA4 mutation leads to partially overlapping phenotypes in humans.
- While hypermethylation of GATA-5 seems to be a universal feature among human tumors, infrequent methylation of GATA-4, and its corresponding overexpression, appears unique to pancreatic cancer from other tumor types reported thus far.
- 4 missense sequence variants (Gly93Ala, Gln316Glu, Ala411Val, Asp425Asn) occurred in patients with cardiac septal defects. 2 led to polarity changes. Non-synonymous GATA4 sequence variants sometimes occur in septal defects & rarely in conotruncal defects
- identification of a novel GATA4 mutation in a patients with ASDII
- the majority of the ovarian surface epithelial carcinomas retained GATA-4 expression, whereas approximately two-thirds of the carcinomas had mislocalization or loss of GATA-6 expression
- The results suggest differential but overlapping functions for GATA-4 and GATA-6 in the normal gastrointestinal mucosa. Furthermore, GATA-4, GATA-6 and Ihh expression is altered in premalignant dysplastic lesions and reduced in overt cancer.
- HNF4alpha regulates thyroid hormone homeostasis through transcriptional regulation of the Dio1 gene with GATA4 and KLF9
- GATA-4 influences granulosa cell fate by transactivating Bcl-2.
- findings are useful in understanding the prevalence of GATA4 mutations and the correlation between the GATA4 genotype and the congenital heart disease phenotype in Chinese patients