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Validated All-in-One™ qPCR Primer for GABRA2(NM_001114175.3) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].
Gene References into function
- GABRA2 might influence susceptibility to alcohol dependence by modulating the level of neural excitation
- extracellular domain models show subunit arrangement of GABA-A receptors
- A complex pattern of alternative splicing and alternative promoter use of the human GABRA2 mRNA was demonstrated. There are four major isoforms consisting of combinations of two alternative 5' and 3' exons.
- Risk for alcohol dependence associated with GABRA2 is not evident until the mid-20s and then remains throughout adulthood, which is also associated with other drug dependence.
- Results suggest an association between marijuana dependence, illicit drug dependence and alcoholism with single nucleotide polymorphismss in the GABRA2 gene.
- A modest associations between GABRA2 genotypes and addiction phenotypes.
- gabra2 gene is associated with risk for alcohol dependence.
- The GABRA2 haplotype block may act in a dominant manner in relation to risk of alcohol dependence.
- no evidence of a relationship between GABRA2 and alcohol dependence
- The assessment of genetic vulnerability may be relevant to studies of the efficacy of psychosocial treatment: GABRA2 genotype modifies the variance in drinking and can therefore moderate power for resolving differences between treatments.
- study of patterns of htSNPs & linkage disequilibrium (LD)in 6 populations; LD extended from most of the GABRA2 gene through the GABRG1 locus in the same GABAA cluster region suggesting possible association of these genes with alcohol dependence
- GABRA2 mRNA levels significantly differed by GABRA2 genotype. GABRA2 single nucleotide polymorphisms were associated with sensitivity to the acute effects of alcohol.
- GABRA2 variation contributes to genetic susceptibility to alcohol dependence. Allelic associations were found for body sway, motor coordination, pursuit rotor and arithmetical computation tasks and neuroticism.
- Genes such as ELTD1 on chromosome 1, in addition to genes on chromosomes 4 (eg, GABRA2) and 6 (eg, CNR1), may be associated with the genetic risk for cannabis use disorders.
- GABRA2 allelic associations found in clinical case-control studies have detectable but minor effects on DSM-defined alcohol dependence in the general community.
- results demonstrated that GABRA2--originally associated with a diagnosis of alcohol dependence in adults--also predicted the onset of symptoms among subjects in their 20s