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Validated All-in-One™ qPCR Primer for XRCC6(NM_001288976.2) Search again
Product ID:
HQP154070
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CTC75, CTCBF, G22P1, KU70, ML8, TLAA
Gene Description:
X-ray repair cross complementing 6
Target Gene Accession:
NM_001288976.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa.
Gene References into function
- Studies on the mode of Ku interaction with DNA
- binding with inositol hexakisphosphate
- regulates osteocalcin gene expression
- Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-terminus
- role of expression in NF-kappaB activation and COX-2 expression
- Ku associates with hTERT, and this interaction may function to regulate the access of telomerase to telomeric DNA ends
- Transcripts of Ku70 and Ku86 genes were detected by RT-PCR and Ku protein was localized in the nucleus of neutrophils as a heterodimer
- In naevus cell naevi, significant correlations were found between Ku70/80 gene expression and some ploidy-related parameters.
- The mechanism that regulates for nuclear localization of Ku70 and Ku80 appears to play, at least in part, a key role in regulating the physiological function of Ku in vivo.
- Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment
- This antigen acts as the transcription factor induced by interleukins (IL)-13 and -4 leading to induction of 15-lipoxygenase (15-LO) in human cells.
- This autoantigen is induced by a divergence in intracellular signaling between IL-4 and IL-13.
- DNA repair proteins Ku70 and Ku80 expression is lost in cell nucleus after oxidative stress
- Ku antigen interacts with RBP-Jkappa and NF-kappaB p50 may act as a positive regulator of p50 expression in gastric cancer AGS cells.
- DNA-PK can be activated by nucleosomes through the ability of Ku to bind to the ends of nucleosomal DNA, and that the activated DNA-PK is capable of phosphorylating H2AX within the nucleosomes
- (ADP-ribosyl)ation of Ku70/80 reduces the ability of this factor to stimulate WRN exonuclease, suggesting that covalent modification of Ku70/80 by PARP-1 may play a role in the regulation of the exonucleolytic activity of WRN.
- Expression of both genes was down-regulated as melanoma progressed. In situ hybridization demonstrated more Ku70- and Ku80-positive cells than immunohistochemical methods, but the correlation between the two methods was highly significant (P <0.01).
- cell-surface Ku functions as an adhesion receptor for fibronectin; both Ku70 and Ku80 present a structural relationship with integrin I (or A) domains and the A1 and A3 domains of von Willebrand factor, domains known to be involved in Fn binding
- activity of ESE-1 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP.
- Results show that Ku70/Ku80 and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) modulate RAG-mediated cleavage during V(D)J recombination.
- DNA-binding component of human OF-1 (which binds Herpes simplex virus type 1 origin of replication) contains Ku70 and Ku80 proteins
- Histone gamma-H2AX promotes binding of nuclear DNA helicase II to transcriptionally stalled sites on chromosomal DNA.
- Ku70/80 interacts directly with the RNA component of human telomerase, independent of the human telomerase reverse transcriptase protein.
- Ku70 has a role in human cancer cell sensitization to radiation and etoposide treatments
- The level of Ku70 in the cytoplasm was decreased, but that of Bax in mitochondria was increased by justicidin A in colorectal cancer cells.
- Ku70 is a receptor for the rickettsial protein rOmpB. Bacterial internalization is dependent on the presence of cholesterol-enriched microdomains containing Ku70.
- Ku70 has other antiapoptotic functions in Granzyme A (GzmA)-induced cell death, which are blocked when GzmA proteolyses Ku70
- The present study suggests that Ku binds IRES -(internal ribosomal entry site)elements within RNA molecules, and that Ku plays a role in the modulation of IRES- mediated mRNA translation.
- Dimeric particles are observed in which two DNA-PKcs/Ku70/Ku80 holoenzymes interact through the N-terminal HEAT repeats.
- Ku-mediated assembly of DNA-PK on DNA ends is responsible for a dissociation of the DNA-PKcs.Artemis complex.
- Functions in nonhomologous DNA end joining.
- The three-dimensional structure of the human full-length Ku70-Ku80 dimer at 25 A resolution, alone and in complex with DNA, by using single-particle electron microscopy was reconstructed.
- poly(ADP-ribose)polymerase-1 and Ku70/Ku80 are transcriptional regulators of S100A9 gene expression
- maintenance of higher expression of Ku70 and Mre11 may be responsible for keeping longer life span observed in the longevity group
- SIRT1 modulates DNA repair activity, which could be regulated by the acetylation status of repair protein Ku70 following DNA damage
- Ku70 protein plays an important role in repair of DNA DSB (double-strand breaks) damage and for maintainance of genome stability.
- These data support a new role for Ku in the migration of monocytes into tissues, which depends on a tightly regulated pathway of intracellular redistribution.
- TrkA signaling appears to be proapoptotic in the absence of Ku70.
- potential relevance of Bin1-Ku interaction to cancer are discussed in light of these findings
- Genes encoding KU70, MGST1 and BIK show age-related mRNA expression levels in hematopoietic stem cells.
- The Ku70 promoter T-991C, but not the Ku70 promoter C-57G polymorphism, is correlated with pterygium.
- These results indicate that Bax and Ku70 acetylation play important roles in Q79C-induced cell death, and that BIP may be useful in the development of therapeutics for polyQ diseases.
- Expression of Ku70 in breast cancer tissue and normal breast tissue with immunohistochemistry are largely equal.
- Ku80 is essential for Ku70 accumulation at DSBs. Three domains of Ku80, i.e., the N-terminal alpha/beta, the DNA-binding, and Ku70-binding domains, seem to necessary for the accumulation at or recognition of DSBs in the early stage after irradiation
- Autoantibodies against Ku are elicited by macromolecular protein complexes containing Ku and the associated DNA damage proteins may be involved of autoimmunity in rheumatic diseases.
- point mutation observed by transcriptome sequencing of malignant pleural mesothelioma tumors
- Ku70 regulates apoptosis by sequestering Bax from the mitochondria and mediating Bax deubiquitylation
- Ku70 mRNA was the marker most significantly associated with response to induction chemotherapy (IC). Moreover, high tumor Ku70 mRNA expression was associated with significantly longer local recurrence-free survival (LRFS).
- Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors.
- Ku antigen as a part of DNA-PK was shown to inhibit abasic site cleavage by apurinic/apyrimidinic endonuclease 1.
- ApoC-IV overexpression may perturb lipid metabolism leading to lipid accumulation. HCV core protein may modulate ApoC-IV expression through Ku antigen and PPARgamma/RXRalpha complex.