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Validated All-in-One™ qPCR Primer for FOLR1(NM_016729.3) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene is composed of 7 exons; exons 1 through 4 encode the 5' UTR and exons 4 through 7 encode the open reading frame. Due to the presence of 2 promoters, multiple transcription start sites, and alternative splicing of exons, several transcript variants are derived from this gene. These variants differ in the lengths of 5' and 3' UTR, but they encode an identical amino acid sequence. [provided by RefSeq].
Gene References into function
- findings suggest that up-regulation of FRalpha gene and calcyclin gene expressions induced by Allitridi may play an important role in human gastric cancer cell differentiation
- The 27 kDa protein representing soluble folate binding protein exhibited a greater affinity for ligand binding than the 100 kDa protein which possesses a hydrophobic tail identical to the one that anchors the folate receptor to the cell membrane.
- Nuclear mRNA instability due to a new ORF element determines tissue specificity of FRalpha. FR-alpha has constitutive mRNA & protein synthesis during the cell cycle & slow protein turnover, ensuring a high steady-state level to override the instability.
- The possible anticancer agent, CB300838 has a low affinity for this carrier which makes it a possible antitumor agent.
- Mutations in the 5'-untranslated region and proximal promoter of the folate receptor-alpha (FR-alpha) gene could be a new factor contributing to gene-food interaction explaining part of the hyperhomocysteinemia panorama.
- Downrwegulated in an antifolate resistant leukemia cell line.
- polymorphism may contribute to susceptibility to gastric cancer in at-risk Chinese
- FBP secreted from epithelia of epididymis & vas deferens. A small fraction of FBP associated with prostasome-like vesicles which adhere to spermatozoa in epididymal duct. FBP may have bacteriostatic function depriving folate-requiring bacteria of folate.
- FRalpha might confer a growth advantage to the tumor by modulating folate uptake from serum or by generating regulatory signals.
- Novel mutations in the 5'-UTR of the FOLR1 gene were discovered in patients with elevated levels of homocysteine.
- This study suggests that FR alpha plays a role in the uptake of 5-methyltetrahydrofolate when the concentration gradient is insufficient for reduced folate carrier -mediated transport.
- intensity of folate receptor staining was strongly correlated with breast cancer outcome
- folate receptor type beta is induced in a bone marrow engraftment model of acute myelogenous leukemia
- Eight novel rare FOLR1 mutations with a combined prevalence of approximately 1.3% in Whites as well as two common polymorphisms with 5% and 13%, respectively, have been demonstrated.
- Higher levels of FOLR1 appear to be associated with better prognoses for patients with lung adenocarcinomas.