|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for ERG(NM_182918.4) Search again
Product ID:
HQP153440
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
erg-3, p55
Gene Description:
ETS transcription factor ERG
Target Gene Accession:
NM_182918.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- chemical shift and secondary structure of the PNT/SAM domains
- role in regulating COL11A2 gene transcription
- ERG plays a role in the development of Alzheimer's disease (AD)-like neuropathology in Down syndrome and in pathogenesis of AD per se; the manifold increase of ERG in both disorders may form a pivotal pathogenetic link.
- Erg and Jun proteins interact in living cells
- The oncogenic TLS-ERG fusion protein activates two different sets of genes sharing little similarity when transforms hematopoietic cells and fibroblasts.
- It is proposed that trisomy 21 facilitates the occurrence of megakaryoblastic leukemias through a shift toward the megakaryoblastic lineage caused by the excess expression of ERG.
- Patients with immunophenotype of Pre-B-acute lymphoblastic leukemia were found to carry: TLS/ERG.
- High ERG expression was associated with upregulation of 112 expressed-sequenced tags and named genes, many of which are involved in cell proliferation, differentiation, and apoptosis in acute myeloid leukemia
- RT-PCR analysis of RNA isolated from bone marrow samples from the patient demonstrates that the translocation occurs within intron 1 of ERG isoform 1 and intron 2 of ELF4 resulting in an in-frame fusion joining exon 2 from ELF4 with exon 2 of ERG.
- Data show the presence of the TMPRSS2/ERG gene fusion is common in prostate adenocarcinoma.
- genomic microdeletion of chromosome 21 is associated with rearrangement, as shown by FISH analysis of TMPRSS2/ERG fusions in prostate cancer
- High expression of ERG is an adverse risk factor in adult T-ALL
- demonstrate for the first time that the TMPRSS2-ERG fusion gene can be detected in a proportion of HGPIN lesions and that this molecular rearrangement is an early event that may precede chromosome-level alterations in prostate carcinogenesis
- ERG overexpression and related ETS transcription factors are important for early prostate carcinogenesis.
- findings show that the TMPRSS2-ERG fusion is common in prostate cancer and that the related TMPRSS2-ETV1 fusion is very rare; frequency of ERG-fusions in the present study is somewhat lower than previously observed
- TMPRSS2:ERG prostate cancer gene fusion may lead to haploinsufficiency or additional fusion events.
- TMPRSS2-ERG fusion protein was found in 35/82 prostate neoplasms.
- Low expression of both ERG and BAALC identifies T-ALL patients with a distinctly favorable long-term outcome.
- presence/absence of Alu family consensus sequence in the introns of TMPRSS2 and ERG correlates with the presence/absence of fusion transcripts and indicates consensus sequence may be involved in prostate cancer
- Clonal ERG rearrangements were found both in high grade prostatic intraepithelial neoplasia (PIN) and in atypical in situ epithelial lesions consistent with the diagnosis of low grade PIN.
- Frequent presence of the TMPRSS2-ERG in index tumors suggests critical roles of ERG alterations in the onset and progression of a large subset of prostate cancer.
- a new pathway regulating angiogenesis and endothelial survival, via the transcription factor Erg and the adhesion molecule VE-cadherin.
- Detection of ETS fusion gene by RT-PCR is feasible on formalin-fixed and paraffin-embedded samples.
- TMPRSS2-ERG with interstitial deletion is an aggressive and, in this study, uniformly lethal molecular subtype of prostate cancer associated with androgen-independent disease
- TMPRSS2-ERG fusion prostate cancer is a distinct molecular subclass. TMPRSS2-ERG expression is regulated by a novel estrogen receptor-dependent mechanism.
- the detection of isolated TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia would improve the positive predictive value of finding TMPRSS2-ERG fusion prostate cancer in subsequent biopsies.
- The TMPRSS2:ERG rearrangement can be found in about one third of prostate cancers. A subgroup of prostate cancer patients with a good prognosis may be identified by the rearrangement.
- IGF1 is a common target gene of Ewing's sarcoma fusion proteins EWS-FLI-1, EWS-ERG and FUS-ERG in mesenchymal progenitor cells
- analysis of the TMPRSS2-ERG splice variants in prostate cancer
- TMPRSS2-ERG gene fusion has a role in prostate cancer characteristics and outcomes
- TMPRSS2/ERG fusion isoforms have variable biological activities promoting tumor initiation and progression.
- study discovered three genomic events associated with ERG rearranged prostate cancer, affecting 6q, 7q, and 16q
- Translocation of TMPRSS2-ERG is not associated with outcome and the aggressive clinical features associated with copy number increas in prostate cancer.