|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for ELAVL4(NM_021952.5) Search again
Product ID:
HQP153152
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
HUD, PNEM
Gene Description:
ELAV like RNA binding protein 4
Target Gene Accession:
NM_021952.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- HuD stabilizes the GAP-43 mRNA through a mechanism that is dependent on the length of the poly(A) tail and involves changes in its affinity for the mRNA
- HuD expression in neuroblastoma
- the importance of post-transcriptional mechanisms in regulating AChE expression in differentiating neurons and implicate HuD as a key trans-acting factor in these events
- Ten HuD-derived peptides immunogenic in HLA-A*0201 restriction demonstrate in vitro binding to the HLA molecule, 8 elicit specific cytotoxic T lymphocytes (CTLs) in a murine model, 2 elicit specific human CTLs, and 1 is naturally processed and presented.
- Significant T-cell activation occurred in response to 74% of the selected HuD peptides in Hu-positive patients, suggesting a role of cellular immunity during the course of anti-Hu syndrome.
- potential role for ELAVL4 suggested as a modifier gene for age at onset of Parkinson's disease
- propose that haploinsufficiency of HuD due to chromosome #1p deletion in neuroblastoma selects for cells that amplify N-myc genes
- Increased expression of HuD in the transgenic hippocampus is associated with a concomitant increase in acetylcholinesterase transcript levels.
- HuD plays a role in the post-transcriptional control of GAP-43 mRNA
- Gene silencing and overexpression of the nELAV member HuD in motoneuronal NSC34 cells indicate that Nova1 mRNA stability and translation are positively and strongly controlled by the nELAV proteins
- an unregulated expression of HuD disrupts mossy fiber physiology in adult mice in part by altering the expression and phosphorylation of GAP-43 and the amount of free calmodulin available at the synaptic terminal
- Association with rs967582 in a third cohort further implicates ELAVL4 as a Parkinson disease susceptibility gene.
- increased level of mRNA transcripts detected in Small Cell Lung Cancer patients