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Validated All-in-One™ qPCR Primer for EEF1A2(NM_001958.5) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene References into function
- This is a putative oncogene in ovarian cancer.
- Review. EEF1A2 is an important ovarian oncogene. The protein elongation network can activate tumorigenesis and inhibit apoptosis.
- These results indicate that the use of cellular promoters such as those for EF-1alpha and ubiquitin C might direct prolonged gene expression in hematopoietic and mesenchymal progenitor cells.
- eEF1A2 may have a role in cytoskeletal remodelling or apoptosis in breast neoplasms
- Overexpression of EEF1A2 and KCIP-1 is associated with lung adenocarcinoma
- there is a physical and functional relationship between eEF1A2 and PI4KIIIbeta
- Regulates oncogenesis through Akt-dependent cytoskeletal remodeling.
- The oncogenicity of eEF1A2 may be related either to its role in protein synthesis or to potential non-canonical functions.
- The expression level of EEF1A2 correlates with cell growth but not apoptosis in hepatocellular carcinoma cell lines with different differentiation grades.
- EEF1A2 is highly homologous and functionally similar to the EEF1A1 oncogene, and was found to be restricted only to the normal tissues of the heart, brain, and skeletal muscle
- Study finds that eEF1A2 stimulates formation of filopodia by increasing the cellular abundance of cytosolic and plasma membrane-bound phosphatidylinositol-4,5 bisphosphate.
- eEF1A2 might play an important role in pancreatic carcinogenesis, possibly by acting as a tumour oncogene.