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Validated All-in-One™ qPCR Primer for CUX1(NM_001202543.2) Search again
Product ID:
HQP152230
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CASP, CDP, CDP/Cut, CDP1, COY1, CUTL1, CUX, Clox, Cux/CDP, GDDI, GOLIM6, Nbla10317, p100, p110, p200, p75
Gene Description:
cut like homeobox 1
Target Gene Accession:
NM_001202543.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq].
Gene References into function
- Transfection of keratinocytes with plasmid DNA leads to the loss of detectable DNA-binding activity of CCAAT displacement protein.
- Analysis of flanking sequences of IgH and Ig kappa V region genes show extensive heterogeneity in frequency and location of CDP binding sites and capability of CDP to bind to the nuclear matrix.
- Data report the characterization of a mammalian coiled-coil protein, CASP, a Golgi protein that shares with giantin a conserved histidine in its transmembrane domain.
- Lack of LF expression in the acute promyelocytic leukemia cell line NB4 is associated with the persistent binding of the silencer CCAAT displacement protein (CDP/cut) to the LF promoter in these cells.
- correlation between binding of CDP/Cux to the DNA pol alpha promoter and the stimulation of gene expression
- CDP, in conjunction with one or more viral proteins, binds to the packaging sequences of Adenovirus type 5 to initiate the encapsidation process
- our data suggested that somatic mutations in CDP gene were rare in unselected uterine leiomyomas
- interaction of G9a with a sequence-specific transcription factor that regulates gene repression through CDP/cut.
- CUTL1 plays a central role in coordinating a gene expression program associated with cell motility and tumor progression.
- Binding of E2 at the binding sites play an important role in overcoming inhibition of E1 complex formation caused by the binding of CDP to the origin of replication.
- PKA-induced phosphorylation results in decreased DNA binding affinity of CUTL1 and diminished CUTL1-mediated cell cycle progression and cell motility.
- Single Nucleotide Polymorphism in CUTL1 is associated with myeloid neoplasias
- CUTL1 transcriptionally up-regulates WNT5A on RNA, protein and promoter level.
- Src plays a crucial role in CUTL1-induced tumor cell migration
- CDP inhibits cytokine-induced NF-kappaB-regulated chemokine transcription in melanoma cells
- CUX1 C-terminal proteolytic processing by a caspase enables transcriptional activation in proliferating cells
- Data show that in renal cell carcinoma, the Cut-like homeodomain protein is involved in FIH-1 transcriptional regulation and is controlled by a specific signaling event involving protein kinase C zeta.
- The data strongly suggest that CDP acts as a major suppressor for Human papillomavirus type 16 P670 transcription by binding to the promoter region in the undifferentiated cells
- Genome-wide location analysis revealed that targets common to p110 CUX1 and E2F1 included many genes involved in cell cycle, DNA replication, and DNA repair.
- This result revealed a negative feedback loop whereby CUX1 shuts down the expression of the protease that cleaves it.
- CUX1 showed evidence of association with the HCMV major immediate early regulatory region and inhibited the capacity of the virus to express ie1 and ie2 transcripts, suggesting that this cellular factor regulates MIE gene expression following virus entry
- study reports that mitotic complex genes Ect2, RacGAP, and MKLP1 are coordinately induced in S phase in proliferating T lymphocytes as well as in epithelial cells, depending upon activity of the CUX1 and E2F1 transcription factors