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Validated All-in-One™ qPCR Primer for CRP(NM_001329057.2) Search again
Product ID:
HQP151977
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
PTX1
Gene Description:
C-reactive protein
Target Gene Accession:
NM_001329057.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- C-reactive protein was higher in arrhythmia than in control patients.
- Acute phase concentrations of CRP induce signaling through the intrinsic immunoreceptor tyrosine-based activation motif of the cytoplasmic domain of FcgammaRIIa, thus providing a molecular basis for the role of CRP in host protection.
- Polymorphism in the CRP gene contributes to a variation in baseline levels of CRP.
- CRP concentrations are a potent independent predictor of future vascular events.
- role in resolution of bacterial infection - review
- data indicate that IL-1 gene polymorphisms known to affect the inflammatory response are highly related to plasma levels of CRP and fibrinogen in patients referred for coronary angiography
- Macrophage uptake of low-density lipoprotein bound to aggregated C-reactive protein: possible mechanism of foam-cell formation in atherosclerotic lesions
- In a mouse model of systemic infection with highly virulent Streptococcus pneumoniae, protection from lethality by human C-reactive protein and endogenous anti-phosphocholine antibodies requires complement, but not Fc gamma receptors.
- CRP can bind to modified lipoproteins, notably to the non-esterified cholesterol on their surface. These interactions may be related to the suggested role of CRP in the local inflammation present in atherosclerotic plaques.
- establishment of age-dependent normal reference range
- REVIEW: CRP (inflammatory markers) and coronary heart disease
- C-Reactive Protein Attenuates Nitric Oxide Production and Inhibits Angiogenesis
- loss of pentameric symmetry is associated with delayed apoptosis of human neutrophils
- has been shown to reflect systemic and, perhaps, vascular inflammation and to predict future cardiovascular events in asymptomatic individuals (review)
- Phe66 is the major determinant of CRP-phosphocholine (PCh) interaction and is critical for binding of CRP to PCh residues in pneumococcal C-polysaccharide.
- C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells
- C-reactive protein has a role in the immune response to oxidized phosphorylcholine-bearing phospholipids in oxidized LDL and on the cell membrane of apoptotic cells.
- an investigation as to whether the levels of this protein in IDDM are related to coronary calcification
- C-reactive protein directly stimulates monocyte adhesion to vascular endothelial cells.
- IL-1 induces CRP expression through 2 overlapping response elements, the binding sites for CCAAT-box/enhancer-binding protein-beta (C/EBP-beta) and p50-nuclear factor-kappaB (p50-NFkappaB).
- CRP exerts an endothelium-independent vasorelaxing effect via potassium channels in vitro, suggesting a role for CRP in the regulation of vascular tone.
- Cardiorespiratory fitness levels in men are inversely associated with CRP values and the prevalence of elevated CRP values.
- Elevated CRP concentrations associated with hemodialysis may be useful for the prediction of proatherogenic reactivity and cardiac hypertrophy.
- The protective effect of human CRP administered to mice exposed to an inflammatory stimulus appears to be mediated by CRP binding to FcgammaRI and FcgammaRII, thus enhancing secretion of the anti-inflammatory cytokine IL-10 and down-regulation of IL-12.
- Obesity is associated with higher fasting insulin level, and fasting insulin is associated with C-reactive protein level, in healthy 2- to 3-year-old children
- association between higher physical activity and lower serum CRP levels is dependent on the lower body fat of more active women, yet independent of oral hormone replacement therapy
- Physical fitness is inversely related to CRP level in children, a relationship that is more pronounced in boys than in girls.
- The kidney as a second site of human C-reactive protein formation in vivo
- As summarized in this review, CRP mediates host defense and protection because it supports three major effector functions: activation of complement, opsonization, and the induction of phagocytosis.
- C-reactive protein expression was found to be an independent prognosticator in patients with esophageal squamous cell carcinoma in the multivariate analysis
- Leishmania donovani can use CRP to improve infection without inducing detrimental macrophage activation
- data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of C-reactive protein and interleukin-6
- in subjects with hypoalphalipoproteinemia or hyperalphalipoproteinemia, HDL-cholesterol levels may account for plasma C-reactive protein variations independent of other potential cardiovascular risk
- the relation between CRP and HbA(1c) in a large national sample of individuals with diabetes
- Data suggest that C-reactive protein seems to enhance local inflammatory reactions ensuing in human myocardial infarcts of more than 12 hours duration.
- Elevated CRP is a risk factor for ischemic stroke, independent of atherosclerosis severity as measured by carotid intimal-medial thickness
- CRP levels significantly correlate with calculated 10-year Framingham Coronary Heart Disease Risk in men and women not taking hormone replacement therapy but minimally with most individual components of the FCR
- In acute myocardial infarction elevated CRP levels may reflect the inflammatory activity of a ruptured plaque
- The CRP gene +1444C>T variant influences basal and stimulated CRP level. These findings have implications both for the prediction and pathogenesis of coronary heart disease.
- CRP was reduced in one case treated with infliximab.
- Circulating CRP concentrations can be markedly suppressed, independently of total adiposity or indeed fat mass, by intense regular physical exercise.
- in a low-risk population, C-reactive protein levels are already elevated between weeks 10 and 14 in pregnant women who develop preeclampsia or deliver a growth-restricted baby
- CRP levels correlate significantly with increasing severity of penile vascular disease
- CRP is produced by smooth muscle cells of atherosclerotic lesions with active disease but not in end-stage plaques
- High-sensitivity CRP serum level predicts further intracranial large-artery occlusive disease-related and any major ischemic events in patients with first-ever TIA or stroke with intracranial large-artery occlusive disease
- serum C-reactive protein was positively related to serum leptin and QTc interval and negatively correlated with HDL-cholesterol in young apparently health men
- potential direct involvement of CRP and IL-6 in atherogenesis.
- CRP stimulates MMP-1 expression by U937 cells through FcgammaRII and extracellular signal-regulated kinase pathway. These findings suggest that CRP may promote matrix degradation and thus contribute to plaque vulnerability.
- Protection against lethality is conferred neither by an autologous acute-phase response to sterile inflammatory stimuli given wild-type mice 24 h before lipopolysaccharide challenge, nor by human CRP, passively administered or expressed transgenically.
- A proatherogenic role for CRP. Transgenic mice expressing human CRP have accelerated progression of atherosclerosis.
- CRP stimulates decay-accelerating factor expression on endothelial cells and thus may protect these cells from complement-mediated cell injury.
- CRP modifies the relation between blood pressure and microalbuminuria.
- the CRP-VLDL complex could have a pathogenic role in disseminating the process of intravascular coagulation
- CRP is unable to induce TF expression in monocytes and MDMs directly. The presence of CRP-induced TF expression in PBMCs suggests that CRP can induce TF indirectly, probably through cross-talk between cells.
- High plasma levels of C-reactive protein were associated with increased risk of incident cardiovascular events among diabetic men, independent of currently established lifestyle risk factors, blood lipids, and glycemic control
- Human recombinant CRP directly inhibits endothelial progenitor cell differentiation, survival, & function, key components of angiogenesis and the response to chronic ischemia,partlyvia an effect of CRP to reduce EPC eNOS expression.
- Elevated blood CRP levels may promote accumulation of monocytes in the atherogenic arterial wall by increasing chemotactic activities of monocytes in response to MCP-1.
- CRP induces caspase-mediated apoptosis of human coronary VSMCs. CRP induced a time- and dose-dependent increase of GADD153 mRNA expression.
- Review summarizes the role of C-reactive protein in atherogenesis and hints at a more complex immunomodulatory effect which transforms the acute inflammatory response to vascular injury into the chronic inflammation seen in atherosclerosis.
- summary of the structure of CRP, its ligands, the effector molecules with which it interacts, and its apparent functions [review]
- CRP directly attenuates the angiogenic and possibly arteriogenic functions of endothelial progenitor cells.
- Elevated CRP levels may provide an additional marker for risk of progression to type 1 diabetes.
- Site-directed mutagenesis of amino acids coordinating Ca2+ drastically decreased the binding of CRP to fibronectin (Fn), indicating that the Ca2+ -binding site indeed formed the Fn-binding site.
- CRP enhanced, in a dose- and time-dependent manner, LOX-1 mRNA and protein levels in aortic endothelial cells. CRP increased, through LOX-1, both human monocyte adhesion to endothelial cells and oxLDL uptake by these cells.
- In young subjects with uncomplicated type 1 diabetes, even slightly elevated high ssensitivity CRP concentrations are associated with reduced coronary vasoreactivity.
- elevated CRP levels do not appear to appreciably mediate the influence of polycystic ovary syndrome on carotid intima-media wall thickness
- Oxidative stress may be a determinant of CRP levels and promote pro-atherosclerotic inflammatory processes at the earliest stages of coronary heart disease development.
- Whether genetic markers can add to information yielded by high sensitivity CRP (hsCRP) in assessing cardiovascular risk needs further evaluation.
- Plasma hsCRP levels were found to be associated with the presence and extent of coronary stenosis in patients with stable coronary artery disease.
- a three allelic SNP located at position -286 from the transcription start, was strongly associated with the plasma CRP concentration, predominantly in patients with coronary heart disease; functionality of this polymorphism remains to be determined
- CRP can significantly influence gene expressions in vascular endothelium.
- Persistent and enhanced inflammatory responsiveness to C-reactive protein increases baseline concentrations of IL-6 and TNF-alpha in blood monocytes and may be involved in the pathogenesis of unstable coronary disease.
- CRP and annexin A5 at physiological concentrations bind to distinct sites of negatively charged phospholipids present in oxidized LDL
- Cardiovascular disease is more common in those with metabolic syndrome or diabetes who have elevated CRP.
- hsCRP and IL-6 appear to be associated with small silent brain infarction, suggesting a role of inflammatory processes in cerebral small vessel disease
- characterization the interaction between CRP and cholesterol
- C-reactive protein elevation predicts the occurrence of atrial structural remodeling in patients with paroxysmal atrial fibrillation.
- CRP specifically induced hyporeactivity to phenylephrine in artery rings mediated via antagonism by NO. CRP did not alter eNOs expression but increased expression of GTP cyclohydrolase-1, the rate-limiting enzyme in the synthesis of tetrahydrobiopterin.
- study showed that plasma adiponectin and tumor necrosis factor alpha (TNF-alpha) were independently and reversely associated with insulin resistance and C-reactive protein levels were related to TNF-alpha and obesity
- results suggest that high levels of plasma high-sensitivity C-reactive protein (HSCRP) are associated with depressed cardiovascular autonomic function and hyperinsulinemia
- reduced levels in Echerichia coli-infected patients with liver cirrhosis, but not abolished even in patients with advanced liver dysfucntion
- Review summarizes new roles for C-reactive protein, an acute phase reactant, which appears to be a promising biomarker for cardiovascular disease, possibly more predictive than cholesterol, and it may play an etiological role.
- The highest association with mortality as well as with cardiovascular diseases, diabetes and rheumatoid arthritis is found for serum CRP above 10 mg/l
- CRP mediates its biological effects on aortic endothelial cells via binding and internalization through Fcgamma receptors, CD32 and CD64
- Presence or absence of hypertension and retinopathy should be taken into consideration for the interpretation of the serum high sensitivity-CRP in diabetic patients.
- CRP is modified in low-fat soy protein diets, suggesting that inflammation may not only attenuate lipid responses, but also aggravate dyslipidemia in hypercholesterolemic subjects consuming a cholesterol-lowering diet.
- analysis of C-reactive protein binding to FcgammaRI, FcgammaRIIa, and C1q
- CRP levels of Type 2 diabetic(t2dm) men with coronary heart disease(CHD) were higher than non-diabetic men with CHD. Positive correlation between serum CRP and HbA1c, fasting insulin and HOMA-IRin T2DM.
- under certain circumstances, acute, pulsatile release of IL-6 does not stimulate synthesis of CRP
- circulating C-reactive protein may have a role in acute myocardial infarction
- present results do not suggest that human CRP is either proatherogenic or atheroprotective in vivo
- mildly elevated levels of CRP in plasma do not contribute to the development of early atherosclerosis in hypercholesterolemic E3L/CRP transgenic mice
- Magnesium intake is inversely associated with plasma C-reactive protein (CRP) levels.
- Association between dietary fiber and level of this protein, an inflammation marker, in diabetes, hypertension, obesity, or a combination of these conditions.
- demonstration that CRP is a strong associating factor of metabolic syndrome in Korean population
- CRP was significantly associated with body mass index.
- CRP levels increase continuously across the spectrum of fasting glucose in both sexes.
- Elevations in pCRP level in medically healthy personality disordered subjects with higher scores of trait aggression and hostility.
- CRP regulation of monocyte TF could contribute to the higher than expected atherosclerotic vascular disease seen in patients with inflammatory rheumatic disease
- Data demonstrate that serum C-reactive protein level was related with gestational diabetes mellitus and weight gain during pregnancy in late second and early third trimesters.
- significantly higher levels in patients with metabolic syndrome than in those without.
- Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients.
- both IL-1B +3954 (C-->T) and CRP +1059 (G-->C) polymorphisms influence baseline CRP values and act independently of each other in male subjects
- common genetic variants of CRP (3'UTR 1846C/T) and IL-6 (-174G/C) are significantly associated with the risk of stroke after cardiac surgery and may have a role in inflammation in post-cardiac surgery stroke
- Persons with higher CRP levels tended to have more prevalent and incident lacunar infarcts, and thus inflammatory processes may be involved in the pathogenesis of cerebral small-vessel disease.
- Recombinant and natural C-reactive protein have opposite effects on atherosclerosis in apolipoprotein E-deficient mice.
- May be a risk factor for and biological marker of stroke and other cerebral small-vessel diseases.
- Results suggest that CRP is related to measures of arterial wave reflection and stiffness in asymptomatic subjects from the community.
- CRP is a procoagulant and has implications for atherothrombosis
- CRP exerted a proinflammatory effect in mesangial cells by inducing MCP-1 gene expression via NF-kappaB activation, which was mediated, at least in part, through intracellular calcium and reactive oxygen species
- Evidence in this review suggests that C-reactive protein is a proatherogenic molecule that plays an active role.
- CRP may have a role in atherosclerotic plaque formation in men but not women
- CRP significantly decreases the expression of thrombomodulin and EPCR in human endothelial cells, thereby promoting thrombogenic conditions.
- CRP levels were elevated in pregnancy compared to postpartum.
- Clustering of family history of diabetes, testosterone and IGF I abnormalities, and high high-sensitive C-reactive protein is associated with metabolic syndrome in Chinese middle-aged men.
- This prospective study shows that levels of C-reactive protein, as a marker of the early pregnancy inflammatory response following frozen embryo replacement cycles, may be absent or suppressed, in contrast to that following in vitro fertilization
- In patients with renal cell carcinomas, a tumor-derived origin of some plasma CRP is likely.
- In a British cohort with risk factor levels representative of a contemporary Western population, CRP concentration was among the strongest predictors of CAD incidence and mortality
- Increased CRP levels are associated with atherothrombosis
- serum hsCRP may have a role in development of ischemic stroke in Japanese men
- Homozygous carriers of the CRP 3' UTR +1444C>T polymorphism do not have a significantly increased risk of spontaneous venous thromboembolism.
- Review discusses clinical significance of different levels of CRP, its role in induction or protection from autoimmunity, and the presence of specific CRP autoantibodies in different autoimmune diseases.
- CRP changes with age. Females have higher CRP values than males. CRP values in Aboriginal people are substantially higher than other populations.
- In cultured PBMC cells from patients with angina, added IFN and CRP further increase TF levels that may contribute to the hypercoagulable state in coronary disease.
- study demonstrated that Leishmania donovani can be induced to start differentiation in response to CRP binding; findigs show that the response requires the binding of CRP specifically to lipophosphoglycan
- CRP is increased in patients with heart failure. Of the clinical parameters of left ventricular dysfunction, direct measurement of left ventricular end-diastolic pressure is most closely associated with CRP.
- C-reactive protein levels are increased after oral administration of 17beta-estradiol in healthy post-menopausal women, but not after intranasal administration
- C-reactive protein (CRP) concentrations may modulate diet-induced changes in plasma lipid and lipoprotein concentrations
- The genetic architecture of C-reactive protein (CRP) is described with special emphasis on the detection and characterization of rare variants.
- A common CRP polymorphism is associated with differences in CRP concentration, free from confounding; null association of the variant with coronary events suggests possible residual confounding in CRP-coronary event association in observational studies
- C-reactive protein augmented MMP-1 and -10 messenger ribonucleic acid expression in vascular endothelial cells. Might provide a link between inflammation and plaque vulnerability.
- in human aortic endothelial cells, CRP upregulates monocyte-endothelial adhesion by activation of NF-kappaB through engaging the Fcgamma receptors CD32 and CD64.
- Changes in circulating adipokine (CRP)levels are involved in the improvement of the metabolic state by exercise and may be useful markers for evaluation and prescription of exercise.
- the shared specificity as well as their shared capability to activate complement, suggest that IgM and the pentraxins CRP and SAP exert similar functions in the removal of apoptotic cells
- C-reactive protein has a role in advanced stage beta-cell dysfunction and insulin resistance in patients with type 2 diabetes mellitus
- An elevated preoperative C-reactive protein concentration is an independent predictor of poor cancer-specific survival in gastro-esophageal cancers.
- High serum C-reactive protein was associated with non-small cell lung cancer
- The EPC clonogenic potential seems to be related to hs-CRP and VEGF levels even in healthy population supporting the concept that these mediators are involved in physiological ECs function.
- Results show a strong impact of single-nucleotide polymorphisms of the C-reactive protein (CRP) gene on plasma CRP, but no direct evidence that genetically controlled CRP levels controlled by CRP SNPs contributed to cardiovascular disease phenotypes.
- CRP limits excessive complement activation on targets via its interactions with both factor H and C4b-binding protein (C4BP).
- C-reactive protein is associated with leptin and interleukin 6 blood levels in Japanese type 2 diabetic patients.
- Widespread vascular CRP mRNA expression, a correlation between serum hsCRP, intimal hypertrophy and plaque CRP, and a coronary hsCRP gradient suggest vascular secretion may contribute to serum CRP levels
- Elevated levels of CRP are associated with the presence and extent of angiographically verified Coronary Artery Disease.
- Genetic variants at the CRP locus were associated with CRP levels, but no association was detected for overall ischemic stroke
- South Asians have elevated C3 & CRP levels; results suggest they have a greater level of chronic subclinical inflammation independent of family history of stroke; C3 is more likely to cluster with features of insulin resistance syndrome compared with CRP
- CRP gene haplotype is associated with blood CRP levels in the elderly, and associated with pulse wave velocity, is an indicator of arteriosclerosis.
- Single-nucleotide polymorphisms (SNPs) of the human CRP gene and the T-T-G haplotype are genetic markers for elevated basal CRP levels and appear to be susceptibility markers for atherosclerosis.
- CRP at concentrations known to predict future vascular events upregulates RAGE expression in human endothelial cells at both the protein and mRNA level. Silencing of the RAGE gene prevents CRP-induced macrophage chemoattractant protein 1 activation.
- C-reactive protein plays a role in development of dementia.
- serum amyloid A and C-reactive protein are expressed differently in exudates and transudates
- prostaglandin-endoperoxide synthase 2 polymorphisms, prostaglandin-E receptor 2 polymorphisms, and C-reactive protein concentrations may have a role in atherothrombosis
- inflammation marker C-reactive protein was significantly and positively associated with level of antibodies to Chlamydia pneumoniae only in heavily exposed (>or=1000 mGy) survivors
- C-reactive protein may have a role in development of carotid atherosclerosis
- The plasma levels of CRP and troponin I were also significantly higher in this group of nine patients, and correlated with urinary protein excretion.
- An aggregation of metabolic risk factors is associated with elevated hs-CRP levels among overweight individuals, particularly in women in Japan
- C allele of the CRP +1059G/C polymorphism is associated with decreased serum CRP levels and increased likelihood of disease involvement of the terminal ileum in Crohn's disease patients
- An elevated preoperative C-reactive protein was associated with increased tumour stage, interleukin-6 and interleukin-10 concentrations.
- LDL cholesterol (LDL-C), smoking and WBC count are, but levels of adiponectin, insulin and CRP are not significantly related to chronic heart disease death
- there is association between serum CRP levels and polymorphisms within the CRP and APOE genes in sib-ships with type 2 diabetes mellitus, a population at increased risk for cardiovascular disease
- age-related macular degeneration(AMD) risk-conferring allele alters the binding properties of CFH, thereby leading to choroidal CRP deposition, contributing to AMD pathogenesis
- C-reactive protein is a marker for active carotid atherosclerosis but not for small vessel disease-related brain lesions.
- Genetic variation within C-reactive protein (CRP) is associated with serum CRP levels in the general population and may be associated with prevalent coronary heart disease.
- novel mechanism of inflammatory gene regulation(C-reactive protein) by LXR ligands
- underlying mechanism depends on fluid-phase interaction between C1q and C-reactive protein
- investigated the role of C-reactive protein response to PCI in the risk of clinical restenosis or new coronary stenosis, considering PCI as a model to stimulate inflammati
- Serum amyloid P (SAP) and C-reactive protein (CRP) may represent different facets of inflammation. The association of SAP with cardiovascular disease in these older adults further supports the role of innate immunity in atherosclerosis.
- sex differences in CRP may reflect sex-related differences in the inflammatory responses to obesity, and may in part, be mediated by leptin.
- The magnitude of the systemic inflammatory response triggered by coronary angioplasty assessed as an increase in CRP level and the history of coronary angioplasty concerning nontarget stenosis remain independent predictors of lesion re-narrowing.
- results suggest that mortality from Streptococcus pneumoniae may be associated with polymorphism of the promoter region of the CRP gene
- NT-proBNP levels correlate with PCT and CRP levels in septic patients.
- in a prospective study of subjects without previous documented CAD, high sensitive C Reactive Protein (hs-CRP) levels at baseline were associated with angiographic characteristics and clinical consequences of plaque instability during follow up
- Genetic variation in the CRP gene is associated with plasma CRP levels and cardiovascular disease risk in older adults.
- CRP acts on the effector cells of the immune system to enhance cell-mediated cytotoxicity
- CRP secretion is substantially heritable in humans, demonstrating pleiotropy (shared genetic determination) with other features of the metabolic syndrome, such as BMI, triglycerides or BP
- The +1444C/T variant in the CRP gene influences the basal CRP level in normal people.
- The effect of mycophenolate on c reactive protein levels is warranted after kidney transplantation.
- International Diabetes Federation definition of metabolic syndrome has a stronger relationship with serum CRP in Chinese men than by ATP III definition.
- investigated the interaction of CRP with oxLDL/beta2GPI complexes and its association with atherosclerosis in patients with diabetes mellitus
- CRP may cause insulin resistance by increasing IRS-1 phosphorylation at Ser(307) and Ser(612) via JNK and ERK1/2, respectively, leading to impaired insulin-stimulated glucose uptake, GLUT4 translocation, and glycogen synthesis
- Elevated CRP concentrations in early pregnancy are associated with an increased risk of preterm delivery.
- Patients presenting early with chest pain with elevated CRP concentrations have a greater long-term risk for death and heart failure.
- complement control protein 6-8 is able to interact with DNA and necrotic cells, but in contrast the His-384 allotype binds these ligands more strongly than the Tyr-384 variant
- body mass index and waist circumference were associated positively with leptin, HOMA, and hs-CRP, and negatively with HDL-Cholesterol
- findings support the hypothesis that serum CRP enhances the development of diabetes
- c-Rel((1-300)) binding to C/EBPbeta increases the affinity of C/EBPbeta for the C/EBP binding site at -53 on the CRP promoter
- A major gene influencing CRP levels appears to be located on chromosome 5p15, with an effect that is independent of diabetes. Another gene on 3p21 may control CRP variation but only in the presence of a diabetic or insulin-resistant environment.
- Serum levels of albumin and CRP correlated with dialysis patients' treatment costs. Achieving the Kidney Disease Outcomes Quality Initiative targets may be associated with lower costs.
- These data suggest that the presence of high producer CRP genotype is deleterious to carotid elasticity in men.
- Exploration of whether inflammation (measured by plasma C-reactive protein (CRP) levels) is related to insulin resistance and to parameters of metabolic syndrome, independent of obesity.
- during the acute phase of stroke/transient ischemic attack, individuals with the AG/GG genotype had significantly elevated CRP concentrations as opposed to those with the AA genotype (2.02 +/- 1.59 vs. 1.73 +/- 1.69 mg/l, P = 0.027)
- These in vivo observations support the hypothesis that CRP modulates NO metabolism and may have implications regarding the mechanisms by which CRP modulates vascular disease.
- A study as to in predicting type 2 diabetes risk in a sample of French Canadian cardiac patients.
- CRP may be a risk marker for mental stress induction in patients with coronary artery disease.
- variation in the IRAK1 gene is associated with CRP concentration in Caucasian women in the Diabetes Heart Study
- increased serum CRP might have an important independent role in increased arterial stiffening and the measurement of serum CRP is a useful predictor for the degree of improvement of arterial stiffening in hypothyroid patients.
- Serum hsCRP for predicting risk of cardiovascular disease is confounded by obesity, ethnicity, gender and comorbidities
- Angiotensin-converting enzyme and C-reactive protein may have roles in chronic obstructive pulmonary disease
- The presence of metabolic syndrome X in women with previous gestational diabetets is associated with high levels of C-reactive protein
- Measurement of the serum hs-CRP level is a simple, cheap, and highly reproducible assay and correlates with IMT and FMD in obese children.
- Serum CRP and cytokines increased drastically in postop hip-fracture elderly patients. Only CRP significantly and independently increased in patients with impaired mental status and in patients with complications after hip fracture surgery.
- evaluate the role of acute phase of inflammation in the elderly patients with suspected and confirmed pulmonary embolism
- CRP serum levels are closely associated with lymph node status but cannot be used as prognostic parameter in patients with vulvar cancer.
- In the Stanislas Family Study, epsilon4 allele of the APOE gene was associated with lower hs-CRP concentration, but not with 5-year changes.
- No significant associations of serum CRP levels with the genotypes of CRP C1444T and IL-1B C-31T were observed. TNF-A -1031CC polymorphism was significantly associated with high CRP values.
- results suggest a contribution of P-selectin and CRP genes in modulating susceptibility to cognitive decline after cardiac surgery
- Increased serum levels of glycated albumin, C-reactive protein and tumor necrosis factor-alpha are associated with the presence and severity of coronary artery disease and renal impairment in patients with type 2 diabetes mellitus
- The C reactive protein (CRP) 1009A>G genotypes and associated haplotypes were associated with lower fasting serum high sensitivity-CRP concentrations in elderly Chinese men.
- CRP directs uptake of Streptococcus pneumoniae to Fc gamma receptors on dendritic cells, enhancing effective uptake and presentation of bacterial antigens and stimulating protective adaptive immunity.
- No a useful markers of acute cellular rejection during the first year after heart transplantation, but may be a marker for allograft vasculopathy.
- A locus on chromosome 10 influences C-reactive protein levels in two independent populations.
- C-reactive protein induces endothelial cell apoptosis and matrix metalloproteinase-9 production in human mononuclear cells
- data suggest that human CRP gene 1059 G>C polymorphism is associated with plasma CRP concentration among Chinese in Taiwan receiving coronary angiography
- Adiponectin, leptin and hs-CRP were associated with variables of cholesterol metabolism. A high ratio of cholesterol synthesis to absorption is characterized by high serum leptin and low adiponectin concentrations.
- Adiponectin was lower and hsCRP higher in the subjects with metabolic syndrome than in those without it
- CRP does not act alone but collaborates with other plasma pattern recognition receptors to form stable pathogen recognition complexes when targeting a wide range of bacteria for destruction.
- Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE-/- mice
- study concludes that polymorphic variants of the CRP & Fcgamma-receptor genes are associated with the clinical phenotype in systemic lupus erythematosus
- Short-term unfavorable prognosis seems to be associated with elevated serum hsCRP levels in patients with stroke.
- CRP and low albumin, markers of inflammation, predict cardiovascular events and morbidity in chronic kidney disease patients before initiation of chronic hemodialysis.
- Our observations suggest that CRP is not causally involved in the pathogenesis of cerebral small vessel disease.
- Characterization of monomeric CRP can be complicated by the its propensity to interact with immunoglobulins and other proteins. Such interactions could serve to eliminate excess of monomeric CRP and to scavenge altered, damaged and denatured proteins.
- Leptin induces CRP expression in human coronary artery endithelial cells via activation of the leptin receptor, increased ROS production, and phosphorylation of ERK1/2
- The relation between CRP levels in end stage kidney disease (ESRD) is not a sensitive method for the determination of inflammatory status in ESRD.
- High CRP level is one of the major contributors to the risk of type 2 diabetes.
- Patients who did not achieve an early-mid treatment CRP level of <5 mg/L, had a shorter time to disease progression or relapse (P = 0.001) as well as a reduced overall survival
- The researchers found evidence that five single nucleotide polymorphisms in the CRP gene are associated with circulating CRP levels at two different time points over the life course.
- Serum hs-CRP levels may be related to the state of asthma exacerbation and allergic inflammation.
- IL-17 is a potent inducer of CRP expression via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation.
- A higher gene expression of CRP, IL-6, and both IL-6 membrane receptors in subcutaneous samples of inflamed patients than in healthy controls.
- This is the first report to demonstrate consistent and profound elevation of hs-CRP in cases of non-alcoholic steatohepatitis compared with in cases of simple nonprogressive steatosis
- The relationship between CRP levels and small vessel disease-related lesions was not apparent in Japanese elderly. The impact of inflammation in the pathogenesis of small vessel disease-related brain lesions seems to be weak.
- CRP was quantitated using PVDF affinity probes and MALDI-MS.
- The pleiotropic association between CRP and obesity, adipokines and cardiovascular risk factors might prove it to be an important link between inflammatory reaction and atherogenesis in which adipose tissue hormones are involved.
- population-based study suggests that the combined presence of unfavorable CFH and CRP genetic profiles is associated with risk of MI.
- hCRP is not proatherogenic but instead slows atherogenesis, possibly through proteasome-mediated protein degradation
- Plasma concentration of CRP and interleukin 6 concentrations increased, and was positive correlated with Thrombosis In Myocardial Infarction frame count in patients with slow coronary flow compared with normal coronary flow subject
- in patients with cardiovascular disease or dyslipidemia, adiponectin was independently positively associated with serum HDL-cholesterol, sVCAM-1 (vascular cell adhesion molecule 1), female gender and negatively with hs-CRP (C reactive protein)
- investigated the association of CRP with extent and progression of atherosclerosis in multiple vessel beds in a large, population-based cohort study
- Data show that C-reactive protein can predict tumor necrosis factor-alpha blocker retention rate in axial ankylosing spondylitis.
- The inflammatory markers, hsCRP, ESR, WBC, fibrinogen, and TNF-alpha, were raised in all patients but were significantly higher in rheumatoid arthritis patients with coronary artery disease who also had periodontal disease.
- The data imply that the CRP gene may be a longevity gene in humans.
- CRP enhances myeloma cell proliferation under stressed conditions and protects myeloma cells from chemotherapy drug-induced apoptosis in vitro.
- The impact of the IL6 -634G allele on serum C-reactive protein elevation is greater in nonsmokers than in current smokers.
- CRP was identified in the blood of colon neoplasm patients.
- Serum level of C-reactive protein is a marker of poor prognosis in hepatocellular carcinoma patients.
- Baseline CRP levels are independently predictive of future Coronary Heart Disease.
- While genetic variation in the IL-6 gene was associated with circulating IL-6 and CRP concentrations, there is little evidence for association between common IL-6 gene variation and adverse cardiovascular outcomes in this population of older adults.
- Suggest low C-reactive protein in healthy individuals may represent physiological status.
- Reference intervals were established with a high analytic performance for OPN and an acceptable analytic performance for OPG and total sRANKL. The study revealed low biological variation for OPN and total sRANKL and high biological variation for hsCRP.
- performance. C-reactive protein was not found to be superior to other acute phase proteins in the differential diagnosis of cancer and infection and in differentiating early stage disease from advanced stage.
- Sleep apnea is independently associated with raised levels of CRP and fibrinogen in patients with acute ischemic stroke.
- In long-lasting persistent AF, lower levels of CRP appear to be associated with maintenance of sinus rhythm after pharmacological cardioversion irrespective of the use of RAS inhibitors.
- In diabetic children with microangiopathy hsCRP level was insignificantly higher compared to controls and to diabetic children without complications. Correlation analysis showed interrelations between hsCRP and systolic blood pressure and HbA1c.
- The association between hsCRP and progression of early carotid atherosclerosis shows sex differences. In further studies analyzing the role of inflammation for cardiovascular diseases and atherosclerosis, these sex differences should be considered.
- In blacks, the haplotype tagged by 3872A (rs1205) was associated with increased risk of non-CV mortality, relative to other haplotypes;this haplotype was associated with decreased risk of early but not decreased risk of late CV mortality in blacks
- There was no relationship between investigated genotypes or haplotypes of estrogen receptor alpha and levels of C-reactive protein in postmenopausal women.
- using a haplotype-based analysis showed no evidence for an association of the Creactive proteinhaplotypes tested with Type 2 Diabeste mellitus
- CRP is differentially present in nipple aspirate fluid and varies by Gail model risk factors
- in women with early atherosclerosis, higher c-reactive protein levels were predictors of adverse events (cerebrovascular or cardiovascular disease or death)
- Intraplaque hemorrhage evaluated by MRI identified neurologically unstable patients with increased levels of high-sensitivity C-reactive protein regardless of the degree of carotid stenosis.
- the CRP synonymous 1059G/C polymorphism affects CRP levels in patients with unstable angina
- Data show that CRP was the most informative for differentiating grade 1 from grade 2 diabetic foot ulcers.
- CRP uncouples eNOS resulting in increased superoxide production, decreased nitric oxide production and altered eNOS phosphorylation.
- Women whose labor will start with PROM have higher CRP values at post-date follow-up than women whose labor starts otherwise.
- 24 hrs following surgery, CRP and IL-6 levels were significantly higher in the abdominal hysterectomy group compared to laparoxcopic hysterectomy and total laparoscopic hysterectomy with transsection of uterine vessels
- Serum CRP was significantly elevated and serum retinol was significantly lower children with type 1 diabetes. Healthy children with CRP levels above 0.6 mg/L had lower levels of retinol.
- Acetylcholine-induced vasodilation in the forearm, but not flow mediated vasodilation, was inversely related to CRP and e-selectin levels independently of traditional risk factors in elderly subjects
- in a Spanish population study, 2.9% of the total variation in circulating CRP levels seem to be explained by genetic variations within the CRP locus. Furthermore, serum leptin levels are strongly associated with serum CRP levels
- in colorectal cancer patients c-reactive protein levels and Ki67 (proliferation-related Ki-67 antigen) expression were associated with poorer cancer-specific survival; Ki67 labelling index and C-reactive protein were correlated
- CRP could significantly increase resistin expression in cultured human PBMC, and this effect was inhibited by simvastatin, suggesting that CRP and resistin might be involved in the pathogenesis of atherosclerosis
- C-reactive protein may play a role in coronary disease, but does not explain the European gradient of CVD risk
- CC genotype of OLR-1 G501C polymorphism is associated with susceptibility and serum C-reactive protein concentration in Chinese essential hypertensive population
- elevated serum C-Reactive Protein (CRP) levels are associated with a less favorable prognosis in patients with surgically treated endometrial cancer
- high prevalence of common and uncommon inflammatory conditions in individuals with high CRP concentrations
- the response to vascular injury provoked by human C-Reactive Protein in ovariectomized C-reactive protein transgenic mice depends on Fc gamma RI and probably requires its expression by F4/80+ cells
- children with history of Kawasaki disease have increased levels of hsCRP (high sensitivity C reactive protein)
- Higher serum levels of CRP could predict the subsequent renal impairment in patients admitted with the worsening of heart failure symptoms.
- Rheumatoid arthritis patients were less likely to have elevated erythrocyte sedimentation rate (ESR)/depressed C-reactive protein. ESR as a measure of inflammation in rheumatic disease may be limited in infection, renal insufficiency, and low albumin.
- CRP 1059G>C polymorphism is one possible genetic determinant for the difference between intra- and extracranial atherosclerosis
- CRP inhibits cholesterol efflux from human foam cells derived from THP-1 and PBMCs in vitro though oxidative stress, ERK1/2 activation, and downregulation of intracellular cholesterol transport molecules ABCA1 and ABCG1.
- The present study demonstrates that CRP could enhance apoptosis in hypoxia-stimulated myocytes through the mitochondrion-dependent pathway but CRP alone has no effects on neonatal rat cardiac myocytes under normoxia.
- Apolipoprotein E-epsilon 4 carriers had significantly lower levels of C-Reactive Protein yet significantly higher levels of Cytomegalovirus antibodies
- C-reactive protein (CRP) serum levels are associated with increased risk and worse outcome of ischaemic events, a serious prognostic sign in Fabry disease.
- C-reactive protein is useful as a biological marker in synovial fluid for diagnosing septic arthritis.
- These data demonstrate that rs3093061 at the -707 site within the CRP gene is an systemic lupus erythematosus susceptibility locus.
- Results of ischemia-modified albumin and CRP were correlated with final diagnoses of nonischemic chest pain (NICP) and acute coronary syndrome (ACS).
- Levels are increased in young women with polycystic ovary syndrome.
- Pre-diagnostic plasma C-reactive protein concentration was not associated with an increased risk of colorectal adenoma
- No relationship between serum CRP levels and the presence and severity of coronary artery disease in patients with stable angina.
- Human CRP did not play a pathogenetic role in early murine atherogenesis in LDLR knockout mice.
- These findings suggest that CRP in plaques or found circulating in CVD patients can influence DC function during atherogenesis.
- CRP has predictive value for CT-evidence of brain edema.
- Serum C-reactive protein concentration is not associated with asthmatic inflammation expressed by bronchial hyperreactivity and should not be considered a marker of the local inflammatory process in atopic or non-atopic asthma.
- The purpose of this study was to analyse morphological changes in small blood vessels of the cardiac syndrome x patients with increased CRP levels
- Data show that cognitive and affective dimensions of hostility, and traitnegative affect are positively associated with plasma levels of CRP.
- In a population of young subjects with type 1 diabetes, there was a significant increase in CRP levels after the onset of microalbuminuria, likely reflecting a general state of inflammation.
- CRP may have a role in atherogenesis and endothelial dysfunction, reducing vasodilatation and affecting vascular smooth muscle cells
- Serum CRP can be seen as a novel, widely available independent prognostic variable of ovarian cancer.
- hsCRP levels should be adjusted for BMI, ethnicity, education level, disease activity and medications when conducting cardiovascular risk assessment in patients with lupus.
- findings show that IL-1beta NFkappakappaB- & C/EBPbeta-dependently induces IL-6-synthesis in hepatocytes; IL-6 consecutively stimulates CRP production; this mechanism may be crucial for acute phase response in general & CRP production in particular
- We found statistically significant associations between four CRP SNPs and CRP serum concentrations. These were not associated with overall or cause-specific mortality, but two were weakly associated with cardiovascular death.
- CRP levels at nephrology consultation were an independent predictor of death in this cohort of oncology patients with acute renal failure
- CRP showed no significant association with mortality in hemodialysis patients
- Decreased levels of adiponectin and increased levels of hs-CRP and IL-1Ra are tightly associated with the components of metabolic syndrome
- C-reactive protein (CRP) levels increased with the increase in conditions of metabolic syndrome (MeS). In patients with acute myocardial infarction AMI, MeS is associated with systemic inflammation.
- Data show that Serum high-sensitive C-reactive protein levels are increased in manic bipolar disorder patients, as compared to euthymic, depressed patients and healthy controls.
- CRP and pro-inflammatory cytokines (IL-6 and IL-8) are strong predictors of all-cause and cardiovascular mortality.
- Serum high sensitivity CRP is independently negatively associated with volume of tibial but not patella cartilage suggesting that subclinical inflammation may predispose to knee cartilage loss in tibial compartment.
- High-sensitivity CRP is correlated with neurologic symptoms and plaque instability in patients with severe stenosis of the carotid bifurcation.
- The function of CRP to prevent formation of foam cells may influence the process of atherogenesis.
- CRP modulates the expression of genes that contribute to both pro- and anti-inflammatory responses in human monocytes. Among these novel anti-inflammatory effects, we show clearly that CRP activates the LXRalpha pathway.
- Levels of high sensitivity C-reactive protein and tumor necrosis factor-alpha have a cumulative effect on the mean values of carotid artery intimal medial thickness in Asian Indian subjects with normal glucose tolerance.
- CRP and C1q regulate the behaviour of platelets, and that this may be an important immunoregulatory mechanism during inflammatory conditions
- increased C reactive protein (CRP) levels in systemic scleroderma correlated with P selectin and Platelet Glycoprotein GPIIbIIIa complex expression.
- C-reactive protein (CRP) level is independently associated with left ventricular mass index, and suggest that measurement of CRP may provide clinically important prognostic information to supplement left ventricular hypertrophy.
- serum CRP level after hepatectomy not only may reflect residual liver function but also may have important metabolic role in regeneration; early dampened CRP response after liver resection may reflect poor hepatic reserve that may have prognostic utility
- CRP was associated with lower scores on cognitive tests of frontal lobe function among females and these associations were driven by the overweight/obese female group.
- In youth, hs-CRP is strongly related with metabolic syndrome and its components, and is also determined by the body composition. This association indicates a precocious proinflammatory state.
- C-reactive protein, migration inhibitor factor (MIF), leptin, and visfatin levels decreased after weight loss.
- Combination of CRP and HMW-adiponectin reflects further metabolic abnormalities compared with each of them in type 2 diabetic subjects.
- Examine association of sleep apnea severity and obesity with insulin resistance, C-reactive protein, and leptin levels in male patients with obstructive sleep apnea.
- IL1B promoter haplotypes characterized by homozygosity for the common allele at -3737, were associated with raised serum levels of C-reactive protein
- There was no association between CRP or anti-CRP antibody levels with atherosclerosis or statin use.
- In a cohort of 496 Caucasian SLE families we estimated basal CRP heritability, h(2)= 27.7%. We typed a dense map of CRP single nucleotide polymorphisms (SNPs) and found that seven were associated with basal CRP.
- The results of structural equation model (SEM) in the Taiwanese women showed that obesity was positively associated with elevated CRP (B=0.69, p<0.001).
- The association between obesity and CRP is at least as strong in African Americans and Hispanic Americans as in white Americans
- C-reactive protein single-nucleotide polymorphism is not associated with endometrial cancer
- in post-myocardial patients, heritability of lung function is at least partly controlled by the C reactive protein gene.
- Essential hypertensive non-dippers compared to dippers exhibit higher hs-CRP values, irrespective of the dipping status definition.
- CRP and SAA strongly correlated up to the fifth day of observation but were not good predictors of mortality in septic shock.
- quantitative insulin sensitivity check index was negatively correlated with hs-CRP
- Ceruloplasmin is a better predictor of the long-term prognosis compared with fibrinogen, CRP, and IL-6 in patients with severe unstable angina.
- Study suggests that in essential hypertension there is an association between protein-bound sialic acid and C-reactive protein, which reflects the clustering of cardiovascular risk factors in these patients.
- Report synergistic effect of amlodipine and atorvastatin on blood pressure, left ventricular remodeling, and C-reactive protein in hypertensive patients with primary hypercholesterolemia.
- The results suggest that CRP1444C/T (T allele as risk factor) genetic polymorphisms may be associated with the non-valvular atrial fibrillation in the Chinese Han population.
- CRP increases after ST segment elevated myocardial infarct, depending on infarct sice, and may be a prognostic marker after myocardial revascularization.
- CRP levels were clearly associated with future coronary heart disease events in a general population of Japanese.
- Serum adiponectin level was decreased and serum CRP and TNF-alpha levels were increased in obese children. Our findings suggest that childhood obesity is associated with inflammatory processes.
- Results provide evidence of specific interactions between CRP and FcgammaR (predominantly FcgammaRI) naturally expressed on macrophage-like cells.
- Elevated CRP in Type 1 diabetes is associated with poor glycemic control, larger body habitus, and other factors comprising the insulin resistance syndrome, but not with complications.
- Evidence of linkage for plasma C-reactive protein levels as a determinant of obesity-related metabolic diseases has been identified on chromosomes 12p11.23 and 12q15.
- high sensitivity C-reactive protein is expressed differently in different ethnic groups in Israel
- in patients with coronary artery disease, combined use of NT-proBNP (N-terminal-probrain natriuretic peptide ) and hsCRP (high sensitivity C reactive protein) significantly increased predictive value for future cardiovascular events
- Elevated C-reactive protein could serve as a marker for carotid stenosis but was not useful to identify plaques at risk for symptomatic conversion.
- the present collaboration will undertake a Mendelian randomisation analysis to help assess the likelihood of any causal relevance of CRP levels to CHD risk
- Elevated plasma C-reactive protein is associated with androgen-independent prostate cancer.
- CRP at levels found during episodes of inflammation directly binds to the activated form of alphaIIbbeta3 and inhibits platelet aggregation.
- IL6 and CRP levels are associated with presence of white matter lesions (WML) and brain infarcts (BI)
- The chemokine receptor CCR5-del32 frameshift mutation is associated with low levels of C-reactive protein, decreased intima-media thickness, and cardiovascular disease risk
- There are several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.
- CRP has a role in true bacteremia in children
- Data show that hs-CRP is a useful tool for early diagnosis of cardiovascular risk in obese children and teenagers.
- Baseline levels of high-sensitivity C-reactive protein are associated with future arterial events in symptomatic peripheral arterial disease patients but cannot stand alone as a predictive tool.
- In the presence of PEt, CRP bound to native low-density lipoprotein in serum also.
- ET-1 was found to be significantly elevated in the plasma in the AIS. There is association between ET-1 and CRP on the fifth day after AIS. Plasma levels of ET-1 and its association with CRP levels may be used as additional biomarkers for AIS.
- The Vitamin D receptor b, a, T, alleles were more frequent in dialysis patients with elevated serum level of C-reactive protein compared with patients with normal C-reactive protein level.
- Serum CRP concentration is favorably related to physical performance, even within a very low range in a community-based elderly population aged 70 years and over
- Functional role for rs3091244(T) in cardiovascular diseases.
- C reactive protein (CRP) might be a sensitive marker for severe asthma.
- Normal levels of C-reactive protein and IL-6, along with the elevated levels of IL-8 in patients with permanent atrial fibrillation (AF), but not in those with paroxysmal AF, suggest a link between a low-grade inflammatory reaction and long-lasting AF.
- Low levels of high-sensitivity C-reactive protein are associated with a significantly more rapid cognitive decline than are high levels in patients with Alzheimer disease, as indexed using the Blessed Dementia Scale.
- Maternal type 1 diabetes increases the foetal plasma CRP concentration and thus might predispose the offspring to development of atherosclerosis.
- PD patients after peritonitis may be associated with prolonged systemic inflammation. CRP (C-reactive protein ) was a better serum marker for monitoring inflammatory status and predicting long-term prognosis in our study.
- NT-proBNP and hsCRP can independently predict all-cause mortality in a non-dialysis CKD population and may have a useful role in risk stratification.
- CRP levels at diagnosis were related to the extent of disease in patients with ulcerative colitis;a predictor of surgery in subgroups of patients with either ulcerative colitis or Crohn's disease
- C-reactive protein levels are linearly associated with levels of N-terminal-probrain natriuretic peptide in cross-sectional and longitudinal analyses of patients with rheumatoid arthritis.
- High high sensitivity-CRP levels are related to obesity and central distribution of body fat, leading to a higher cardiovascular risk among Mexican subjects
- Elevated CRP levvels may be useful in risk stratification for pulmonary disease in people with metabolic syndrome.
- plasma alkaline phosphatase may have a role in systemic inflammation in Hong Kong Chinese, but it is unknown whether C-reactive protein has a similar role
- findings suggested that more chronic, severe inflammation might be involved in the pathogenesis of variant angina, manifested by increased counts of circulating inflammatory cells and elevated plasma levels of CRP and IL-6.
- weaker association observed between CRP and creatinine-based measures reflects the misclassification of elderly frail subjects as having normal kidney function rather than suggests cystatin C itself to be a marker of inflammation
- The diagnostic performance of hsCRP in distinguishing 3-vessel coronary artery disease from less extensive forms of coronary atherosclerosis is more accurate in a group of subjects without the apoE epsilon4 allele than in patients with it.
- C-reactive protein can stimulate smooth muscle cell migration by a mechanism that may involve upregulation and activation of PDGFRbeta
- Pravastatin immunomodulates IL-6 and C-reactive protein, but not IL-1 and TNF-alpha, in cardio-pulmonary bypass
- Report effects of N-terminal pro-B-type-natriuretic peptide and C-reactive protein vs angiographic severity in predicting major adverse cardiovascular events and clinical restenosis after coronary angioplasty.
- Increased CRP was associated with hypertension, there were interactions between increased CRP and cigarette smoking, and insulin resistance on hypertension in Mongolian people.
- The hypertriglyceridemic waist contributes to the metabolic syndrome and most likely is an important factor increasing high-sensitivity C-reactive protein levels and consequently, relative coronary risk in patients with type 2 diabetes of any sex and age
- although G-CSF induces an inflammatory reaction leading to CRP production, it has direct beneficial effects protecting ECs from the deleterious effects of CRP through activation
- Middle aged hypertensives with obstructive sleep apnea had increased levels of CRP, IL-6, IL-18, TNF-alpha, and asymmetric dimethyl-arginine.
- high serum C-reactive protein levels is associated with cardiovascular disease in a socioeconomically disadvantaged population
- The summary odd ratio indicated that H. pylori infection could influence the serum hsCRP level.
- The nature of the association between CRP phenotype and diabetes development using CRP haplotypes as instrumental variables, was examined.
- CRP is higher in apo E3/3 than in 3/4 subjects and in women compared with men, but remains unchanged by 6 months of standard aerobic exercise training to reduce cardiovascular disease risk. How apo E genotype affects CRP is not known.
- If elevated serum/plasma levels of CRP are associated with neovascular age-related macular degeneration, it is likely not due to genetic variation within CRP, but likely due to variations in some other genetic as well as epidemiological factors.
- an etiological role for CRP in some cancers
- CRP directly increases macrophage lipoprotein lipase expression and secretion. Given the predominant role of macrophage LPL in atherogenesis, LPL might represent a novel factor underlying the adverse effect of CRP on the diabetic vasculature.
- CRP +1444 C-->T and TNF-alpha -308 G-->A polymorphisms are associated with predisposition to Kawasaki disease and, in patients with Kawasaki disease, increased carotid arterial stiffness and intima-media thickness in the long-term.
- Multivariable standard regression analysis and Mendelian randomization analysis suggest that the association of CRP with carotid atheroma may not be causal.
- Findings do not support a causal association between circulating CRP and coronary disease risk, but very large genetic association studies would be required to rule this out.
- The level of serum IL-6 or genetic IL-6 polymorphism is correlated with the complexity of coronary plaque in patients with stable coronary artery disease (CAD).
- In a population free of major cardiovascular disease (CVD) at baseline, CRP was significantly related to risk of CVD.
- a role for CRP in direct stimulation of angiogenesis and therefore may be a mediator of neovessel formation in the intima of vulnerable plaques.
- Discrete episodes of unemployment may have long-term implications for future CRP levels.
- There was a positive strong correlation between Asymmetric dimethylarginine and C reactive protein levels in young men with familial Mediterranean fever.
- Complement factor H binds to denatured rather than to native pentameric C-reactive protein.
- unique haplotype combinations in the CRP gene may modify the risk of developing systemic lupus erythematosus and influence circulating CRP levels
- Data show that secondary antiphospholipid syndrome patients had significantly elevated serum high-sensitivity C-reactive protein levels in comparison to primary antiphospholipid syndrome patients.
- In a population-based cohort of African Americans, circulating CRP concentration was heritable and associated with several traditional cardiovascular risk factors, particularly body mass index.
- first trimester concentrations of maternal plasma CRP in low risk subjects do not appear to be significantly associated with CRP genotype.
- Our study suggests that in the acute phase of the cerebral infarction CRP might be either a marker of cardioembolism or a predictive factor for short-term mortality.
- Measures of inflammation, such as CRP, and indices of atherosclerosis, such as coronary calcium store, are likely to provide distinct information regarding cardiovascular risk
- C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm is independent of the most important CRP genetic polymorphism.
- Examine the role of high-sensitivity C-reactive protein in asymptomatic intra- and extracranial large artery diseases.
- High-sensitivity C-reactive protein is not independently associated with peripheral subclinical atherosclerosis.
- patients with Alzheimer's disease showed lower CRP levels than patients with vascular dementia, mild cognitive impairment or depression
- In the nondiabetic population, smoking associates differently with subclinical inflammation between genders, with a decreased adiponectin level in women and with an increased hs-CRP level in men.
- Autoantibodies against mCRP are prevalent in patients with lupus nephritis and are associated with disease activity and renal tubulointerstitial lesions
- Higher serum high-sensitivity CRP levels are positively associated with diabetes mellitus in a sample of US non-Hispanic blacks.
- Assessment of the prognostic value of C-reactive protein in the prognosis of acute pancreatitis.
- C-reactive protein elevation and rapid angiographic progression of nonculprit lesion in patients with non-ST-segment elevation acute coronary syndrome.
- Polymorphisms in the CRP gene are associated with marked increases in CRP levels and thus with a theoretically predicted increase in the risk of ischemic vascular disease.
- C-reactive protein (CRP) level predicts rheumatoid arthritis progression to major joint replacement after standardisation for relevant risk factors.
- As previously shown in women, a prediction model in men that incorporates high-sensitivity C-reactive protein and parental history significantly improves global cardiovascular risk prediction in men.
- hs-CRP (high sensitivity C Reactive protein) was associated with disease activity but not with overall damage accrual; it correlated with specific domains of the damage index
- CRP up-regulates M-CSF release from human monocyte-derived macrophages and human aortic endothelial cells and increased macrophage proliferation.
- the structural mechanism for pentraxin's binding to FcgammaR and its functional activation of FcgammaR-mediated phagocytosis and cytokine secretion
- The significant association between the AGTR1 polymorphism and hsCRP levels, which appears to be independent of anthropometric and metabolic traits, is yet another indication of a direct influence of renin-angiotensin system on inflammation.
- Early measurements of IL-6 in extracorporeal membrane oxygenation patients could give prognostic information beyond that of C-reactive protein.
- High C reactive protein and high serum fibrinogen provide prognostic information in chronic kidney disease patients.
- C-reactive protein may have a role in metabolic syndrome
- Although circulating C-reactive protein (CRP) levels are associated with aortic pulse wave velocity, CRP does not have a causal role in the development of arterial stiffness. CRP may simply act as a marker of vascular damage.
- These data identify CFHR4 as a novel ligand for native CRP, and suggest a role for CFHR4 in opsonization of necrotic cells.
- Single nucleotide polymorphisms at the -390 position of the CRP gene promoter region influence CRP basal levels in such a way that the "C" allele correlated with the lowest and the "T" with the highest after kidney transplantation.
- Prognostic utility of apoB/AI, total cholesterol/HDL, non-HDL cholesterol, or hs-CRP as predictors of clinical risk in patients receiving statin therapy after acute coronary syndromes: results from PROVE IT-TIMI 22.
- Glucose at admission and resistin are independently associated with elevated levels of CRP in men during the early stage of acute myocardial infarction.
- In recently diagnosed hypertensive subjects, hsCRP and sE-selectin levels are related to awake systolic blood pressure variability.
- In women suffering from polycystic ovary syndrome, pregnancy complications were associated with elevated blood/serum levels of haemoglobin and C-reactive protein
- Our findings suggest that common genetic variation in CRP genes may contribute to heterogeneity of COPD population associated with systemic inflammation
- C-reactive protein correlates with tissue oxygen availability in patients with stable COPD.