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Validated All-in-One™ qPCR Primer for CRHR2(NM_001883.5) Search again
Product ID:
HQP151965
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CRF-RB, CRF2, CRFR2, HM-CRF
Gene Description:
corticotropin releasing hormone receptor 2
Target Gene Accession:
NM_001883.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Gene References into function
- Detected in placenta, myometrium, decidua, and fetal membranes. Widespread expression of CRH system in gestational tissue suggests paracrine role CRH in birth process (e.g. effects on macrophages and endothelial cells).
- data suggest a distinctive role for corticotropin-releasing hormone receptor 2 specific agonists like urocortin II in the control of myometrial contractility during human pregnancy
- CRH-R1:CRH-R2 ratio varied according to fat-depot type; whereas CRH-R1 expression was higher in sc fat than in visceral fat, the opposite was true for CRH-R2.
- The regions of the CRF2(a) promoter that regulate the inducible expression were determined
- ligand binding properties of CRFR2
- expression by semiquantitative reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescent immunocytochemistry in umbilical cord blood-derived cultured mast cells
- CRHR2 polymorphisms examined do not confer susceptibility to panic disorder.
- adrenocortical cells exhibit a higher expression of functional CRH receptors than chromaffin cells and that CRH acts on adrenal DHEA production
- expression of CRH-BP, CRH-R1 and CRH-R2 in uterine tissues is down-regulated during pregnancy; the most pronounced down-regulation of CRH-BP and CRH-R2 occurred in laboring cervix, irrespective the length of gestation
- Results demonstrate corticotropin-releasing factor (2) expression in the human gastric mucosa and indicate a physiological role of this receptor type in regulating apoptosis, an important parameter of gastric cell regeneration.
- Both CRHR1 and CRHR2 play a facilitatory role in the non-clathrin-, non-caveolae-mediated endocytosis and intracellular signal transduction of urocortin.
- in chorion trophoblast cells, CRHR1 and CRHR2 mediate divergent effects on PGDH expression, and this may provide a precise regulation of PGs levels from chorion to myometrium during pregnancy
- results show that haplotype variation at the CRHR2 locus is associated with suicidal behaviour
- Human myometrium expresses both CRH-R1 and CRH-R2 during pregnancy.
- Cultured placental trophoblasts express both CRH-R1 and CRH-R2.
- Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma.
- UCN inhibited the proliferation and promoted the apoptosis of endothelial cells and down-regulated VEGF expression in vivo via CRFR2.
- Expression loss of CRFR2 in prostate cancer and its neovascularization contributes to prostate tumorigenesis, progression, and neoangiogenesis.
- receptors couple to different G-proteins in stably transfected human cells, leading to transient divalent calcium ion mobilization on top of the natural increase in cyclic AMP stimulation.