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Validated All-in-One™ qPCR Primer for CREM(NM_182769.3) Search again
Product ID:
HQP151947
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CREM-2, ICER, hCREM-2
Gene Description:
cAMP responsive element modulator
Target Gene Accession:
NM_182769.3(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq].
Gene References into function
- review of CREM transcription factor involvement with spermatogenesis
- Increased expression of CREM in T cells from systemic lupus erythmatosus (SLE) patients results from increased transcriptional activity of the CREM gene, and its binding to IL-2 promoter is responsible for decreased production of IL-2 by SLE T cells.
- 5'-RACE on human testis cDNA indicated that exon theta2 is > or = 113 bp in size. In-vitro translation of CREM-theta1 and CREM-theta2 splice variants cloned from human testis yielded full length proteins and also shorter repressor products
- Direct binding of CREM to the CRE site of the IL-2 promoter endows CREM with a central role in repression of IL-2 gene expression: CREM binding promotes chromatin deacetylation, limits promoter accessibility and decreases its transcriptional activity.
- expression of cAMP-responsive element modulator(CREM) activators is a prerequisite for normal spermatogenesis, and the lack of CREM activator expression results in male infertility
- CREB-1/CREM-1 have roles as regulators of macrophage differentiation
- These findings provide little additional evidence for a susceptibility locus for panic disorder either within the CREM gene or in a nearby region of chromosome 10p11 in our sample
- Sperm nucleus PHGPx expression is mediated by the transcription factor CREM-tau, which acts as a cis-acting element localized in the first intron of the PHGPx gene. [CREM-tau]
- down-regulation of CREMtau-mediated gene expression by GCNF
- Lack of spermatid elongation was not due to defective CREM expression. Therefore, CREM did not play a pathogenetic role in the onset of SMA in humans.
- that heart-directed expression of CREM-IbDeltaC-X leads to complex cardiac alterations, suggesting CREM as a central regulator of cardiac morphology, function, and gene expression
- isoforms regulate discrete groups of genes in myometrium
- Results identify calcium/calmodulin-dependent kinase IV as being responsible for the increased expression of CREM and the decreased production of interleukin-2 in systemic lupus erythematosus T cells.
- CREM activator and repressor isoforms were found in all germ cell types, but not in Sertoli cells; data suggest a fine-tuning between CREM activator and repressor isoforms in normal germ cells that might be disturbed during impaired spermatogenesis
- SRp40 regulates the switch in splicing from production of CREMtau(2)alpha to CREMalpha
- Screening of a substantial number of patients would be required to clarify whether observed combinations of genetic changes in the CREM gene might explain some forms of male infertility.
- The interaction between CREM and one haplotype of ACT (activator of CREM in the testis) was reduced by 45% in a yeast two-hybrid assay.
- HNF4alpha, CREM, HNF1alpha, and C/EBPalpha have roles in transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine
- These results constitute the first demonstration of the transcriptional control of ATP1A4 gene expression by cAMP and by CREMtau, a transcription factor essential for male germ cell gene expression.
- functional analysis of isoforms from the testes
- CREMalpha exerts its repressor activity by a mechanism that involves recruitment of HDAC1, increased deacetylation of histones, and repression of promoter activity.
- CREM-alpha mRNA levels were higher in T cells from patients with systemic lupus erythematosus than controls while CREB mRNA levels did not differ between the two groups
- The positive-feedback loop described in this review is regulated by phosphodiesterase 3A and ICER and is pathologically important in adult hearts.
- Data show that inducible cAMP early repressor splice variants ICER I and IIgamma both repress transcription of c-fos and chromogranin A.
- Transcription factors of the CREB/CREM/ATF family have a moderate effect on human MC2-R promoter activity, but seem to play a minor role in transmitting stimulation of the cAMP pathway to increased MC2-R expression.
- CREM is an essential regulator of NIS gene expression.
- CREM has a role in CYP1A1 induction through ligand-independent activation pathway of aryl hydrocarbon receptor in HepG2 cells
- CREB/ICER expression needs to be considered a pathogenetic feature in leukemogenesis
- BDNF- and seizure-dependent phosphorylation of STAT3 cause the adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB) family member ICER (inducible cAMP early repressor) to bind with phosphorylated CREB at the Gabra1:CRE site.