|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for CREB1(NM_134442.5) Search again
Product ID:
HQP151915
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CREB, CREB-1
Gene Description:
cAMP responsive element binding protein 1
Target Gene Accession:
NM_134442.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
Gene References into function
- review of CREB transcription factor involvment with spermatogenesis
- Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB.
- CREB and sterol regulatory element binding protein cooperate in transactivating CYP51.
- is co-expressed with CREB and CBP in extravillous cytotrophoblasts, revealing the in vivo relevance of this transactivation pathway
- CREB-DNA binding by magnetic fields is dependent on calcium ions.
- hGRP-R activation stimulated sustained cyclic AMP response element binding protein (CREB) phosphorylation and transactivation in duodenal cancer cells through a protein kinase C and partially p38 mitogen-activated protein kinase-dependent pathway.
- CREB activity is an important step for nitric oxide-mediated survival in neuronal cells
- Oct-1 potentiates CREB-dependent cyclin D1 transcriptional activity by a phospho-CREB and CREB binding protein-independent mechanism
- CREB1 plays an important role in the trans-activation of the MHC class II trans-activator (CIITA) promoter III in B cells.
- Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB
- CREB response to hypoxia is modified by small ubiquitin-related modifier-1 (SUMO-1)
- Here we show that HDAC1 associates with and blocks Ser133 phosphorylation of CREB during pre-stimulus and attenuation phases of the cAMP response
- CREB1 associates with TIF2 and is essential for cell transformation.
- IL1beta and TNFalpha activation of MSK1 and CREB and cAMP-response element signaling cascades occurs via ERK/p38 MAP kinases and are crucial aspects of the intracellular mechanisms that mediate MUC5AC gene expression
- Levels of CREB mRNA in thyroid carcinomas, but not in adenomas, were significantly lower than in corresponding normal tissue.
- Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation.
- The involvement of CREB in STAT5 transactivation was demonstrated by serine-133-mutated CREB, which completely blocked the SCF effect. In addition, the CREB-binding protein CBP/p300 was shown to be essential for EPO- and SCF-mediated STAT5 transactivatio
- Sequence variations in the CREB1 promoter and intron 8 have been detected that cosegregate with Mood Disorders, or their absence, in women from these families, identifying CREB1 as a sex-limited susceptibility gene for unipolar Mood Disorders.
- observed CREB phosphorylation via signal pathways and binding of CREB to the cAMP-responsive element after treatment with oxidized phospholipids
- role in assembly of CBP-CREB-HTLV-1 tax coactivator-activator complex
- CREB-binding protein interacts preferentially with the glycosylated form of Stat5
- activation of BTK and the subsequent phosphorylation of CREB at Ser-133 are important in the neuronal differentiation of hippocampal progenitor cells.
- chronic activation CREB and p90RSK in the epileptic hippocampus may be closely associated with the histopathological changes of Ammon's horn sclerosis
- CREB-1 has a role in the cAMP-induced expression of the survival motor neuron (SMN) gene
- CREB-1/CREM-1 have roles as regulators of macrophage differentiation
- CREB is activated by TNF/TNFR1 signaling through a p38MAPK/MSK1 signaling pathway.
- CREB has a role in PPARgamma2 inhibition of cyclin D1 transcription in hepatocytes
- In VSMCs, LDL-induced mitogenesis involves NOR-1 upregulation through a CREB-dependent mechanism. CREB could play a role in the modulation by LDL of key genes (containing CRE sites) involved in atherogenesis.
- CRH plays pathogenic role in modulating inflammatory joint disease with CREB/ATF family of transcription factors as principal effector molecules of proinflammatory mediator action in rheumatoid arthritis.
- identified the in vivo binding sites of CREB1 across the entire human chromosome 22; a large number of potential gene targets for CREB1 have been identified, raising the possibility that it has important roles in a variety of cellular processes
- CREB suppresses the glioblastoma proliferative effect of the stress-induced acetylcholinesterase variant, AChE-R
- Resistance to various antifolates may potentially be associated with impaired activity of Galphas or their coupled receptors, resulting in loss of CREB-1 phosphorylation.
- This review article highlights the current findings on the role of nucleus accumbal and amygdaloid CREB signaling in behavioral consequences of alcohol use and abuse.
- SDF-1/CXCL12 enhanced cell survival in synergy with other cytokines involves activation of CREB and induction of Mcl-1 and c-Fos
- p90 ribosomal S 6 protein kinase 1 (RSK1) mediates the PGE2-induced phosphorylation of cAMP-response element binding protein
- affects the expression of 958 genes in myometrium
- CREB phosphorylation alone is not a reliable predictor of target gene activation and that additional CREB regulatory partners are required for recruitment of the transcriptional apparatus to the promoter.
- CREB promotes abnormal proliferation and survival of myeloid cells in vitro and in vivo through upregulation of specific target genes and thus is implicated in myeloid cell transformation.
- The contribution of CREB to interferon(IFN)-gamma upregulation is demonstrated in T cells from normal tuberculin reactors, compared to T cells from tuberculosis patients with ineffective immunity, which show reduced CREB activity and low IFN-gamma levels
- the PI3-kinase/p38(MAPK)/CREB pathway contributes to the EGF activation of NF-IL6beta gene expression
- Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner
- Results do not support the previous evidence for CREB1 as a major factor contributing to depression.
- phosphorylation of CREB is increased by 8-bromo-cAMP, which has opposite effects on TNF and TNFR1 mRNA expression
- Elevated levels of phosphorylated cAMP response element binding protein is associated with lung tumorigenesis
- results demonstrate that regulation of mitochondrial gene expression by mitochondrial CREB, in part, underlies the neuron protective effects of CREB
- Results suggest that hypoxia promotes intestinal epithelial amphiregulin expression in a CREB-dependent manner, an event that may contribute to increased proliferation.
- CREB/ATF1 and c-Jun were shown to bind to an oligonucleotide encompassing a distal, conserved CREB/AP1 site in the 5'-flanking region of the MUC2 gene, and this cis element was shown to mediate promoter reporter activation by VIP
- metastatic melanoma cells overexpressing CREB/ATF-1 are better equipped than nonmetastatic cells to respond to PAF within the tumor microenvironment.
- expression of PEN-2 is regulated by CREB, and the specific control of PEN-2 expression may imply additional physiological functions uniquely assigned to PEN-2
- Considered together, these results underscore a primary role of CREB in preventing apoptosis triggered by Bax, and suggest that Tax might act by affecting the phosphorylation state of CREB.
- Findings collectively suggest that CREB phosphorylation may be employed as an in situ marker for hypoxia. Moreover, hypoxia and/or phosphorylation of CREB are associated with the cell invasiveness of pituitary adenomas.
- Akt-and CREB-mediated prostate cancer cell proliferation is inhibited by Nexrutine, a Phellodendron amurense extract
- The presence of CREB, Tax and RNA Polymerase II at the p97Vcp and Sgt1 promoters in vivo through chromatin immunoprecipitation in CTLL/WT cells has been confirmed.
- gamma-gene induction by butyrate and trichostatin A involves ATF-2 and CREB1 activation via p38 MAPK signaling.
- intracellular HIV-Tat induces IL-10 transcription by ERK MAPK-dependent CREB-1 transcription factor activation through Ser(133) phosphorylation
- leptin, which is increased in inflamed colonic mucosa, triggers colonic expression of hPepT1 via the CREB and Cdx2 transcription factors
- We observed that the CRE-DNA binding and the protein expression of CREB were significantly decreased in the PFC of teenage suicide victims compared with controls.
- Binding of CREB1 to the CD1A promoter in human monocytes suggests a role for ATF/cAMP response element binding protein family members in regulation of CD1A expression
- Heterodimerization of unphosphorylated CREB with either mutant A-CREB or inducible cAMP early repressor triggers CREB protein degradation, whereas phosphorylation prevents CREB from such degradation both in vitro and in vivo.
- results suggest that extracellular HIV-Tat induced IL-10 transcription in primary human monocytes is regulated by CREB-1 and Sp-1 transcription factors through the activation of calmodulin/CaMK-II-dependent p38 MAPK
- in contrast to Akt1, Akt2 was unable to induce CREB phosphorylation at Ser-133 in vivo and CREB target gene expression; findings suggest that the regulatory domain of Akts contribute to the functional difference between Akt1 and Akt2
- Here we report that the human SOX9 proximal promoter is also regulated by the cyclic-AMP response element binding protein (CREB) and Sp1.
- These preliminary results suggest a strong, gender-specific association between variation at the CREB1 locus and anger expression in major depressive disorder.
- CREB may regulate VEGF transcription via a hypoxia-inducible factor-dependent mechanism in normoxic conditions.
- PKD1 stimulates GAL4-CREB-mediated transcription in a Ser-133-dependent manner, activates CRE-responsive promoters
- a novel mechanism for activation of the activity of ATM kinase by retinoic acid , and implicate ATM in the regulation of CREB function during RA-induced differentiation.
- Tax promotes CREB phosphorylation in vivo to ensure availability for Tax transactivation in HTLV-1 infections
- PRKCD-mediated CREB activation regulates ghrelin-induced COX 2 expression and dinoprostone production in colonic epithelial cells.
- mediates the differential effects of cAMP and stress pathways on CREB target gene expression in conjunction with TORC2
- The luciferase reporter incoporates CREB and provides optimal perfomance for use in G-protein-coupled receptor drug discovery efforts.
- the CREB transducer of regulated CREB activity 1 coactivator undergoes neuronal activity-dependent translocation from the cytoplasm to the nucleus [review]
- CREB has a role regulating CRE-mediated gene expression during cerebral ischemia [review]
- the basic leucine zipper domain has a role in the regulation of transcriptional activity of CREB with TORC and salt inducible kinase [review]
- CREB has a role in oncogenesis [review]
- the expression of p-CREB is related, in asthma, to the persistent inflammation according to the disease severity. p-CREB expression can be modulated by glucocorticoids in responsive patients.
- Findings suggest that interaction between CREB1 and OPRM1 may be important in nicotine reward.
- Data demonstrate that CREB activation via nonclassical retinoic acid signaling may regulate the expression of mucin genes, including MUC5AC, and mediating the early biological effects of RA during normal mucous differentiation in NHTBE cells.
- findings suggest that CREB plays an important role in the pathogenesis of acute leukemia and is a potential biomarker of disease
- Transcription factors of the CREB/CREM/ATF family have a moderate effect on human MC2-R promoter activity, but seem to play a minor role in transmitting stimulation of the cAMP pathway to increased MC2-R expression.
- report for the first time the presence of EWSR1-CREB1 in angiomatoid fibrous histiocytoma, which now appears to be the most frequent gene fusion in this tumor
- p38/CREB phosphorylation and COX-2 expression are inhibited by olive oil polyphenols
- The level of CREB1 in breast cancer patients is elevated and is significantly raised in patients with metastatic disease
- In CREB-overexpressing transfected cells, Meis1 RNA expression was 3-fold higher than in untransfected cells. In AML cells, it was 5- to 10-fold higher than in the control cells. CREB overexpression may result in leukemia.
- overexpression of either CREB or ATF4 enhanced the activation of the HEC1 promoter and overexpression of both of them had an additive effect on the activation of the HEC1 transcription.
- A pathway comprising PKCs>Raf-1>MEK-1>ERK-1/-2 mediates the effect of gastrin on the CgA promoter, and strongly suggests that enhanced phosphorylation of Sp1 and CREB is crucial for CgA transactivation through the G protein-coupled CCK-B/gastrin receptor
- a novel link between TLR4 and a calcium-dependent signaling cascade comprising CaMKIV-CREB-Bcl-2 that is essential for DC survival.
- CREB is critical for normal myelopoiesis and leukemia cell proliferation
- involvement of CaMKs in the control of glutamate-induced proliferation at a common step downstream of CREB
- CREB protein was significantly high (p<0.001) at diagnosis but not during remission
- CREB is a critical positive regulator of constitutive human MIF gene expression & and thus of MIF-dependent host antimicrobial innate immune defense.
- These data reveal that phosphorylation of CREB is not sufficient for CBP/p300 recruitment and transcriptional activation.
- Lyl1 interacts with CREB1 and alters expression of CREB1 target genes.
- results suggest that the CREB1-1H SNP (G/A change), and the CREB1-7H SNP (T/C change) may be associated with bipolar disorder and/or lithium response.
- although IE86 does repress the UL144-mediated activation of a synthetic NFkB promoter, it is unable to block UL144-mediated activation of the CCL22 promoter, and this lack of responsiveness to IE86 appears to be regulated by binding of CREB.
- HTLV-1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding
- not only CREB but also Sp1 plays a critical role in regulating basal CD2AP promoter activity in renal tubular epithelial cells
- Its phosphorylation regulates activation of MITF and expression of tyrosinase.
- CREB is a critical regulator of human GRP-R expression in gastrointestinal cancer and might be activated through different upstream intracellular pathways.
- CREB decreases the protein level of RCAN1, which is overexpressed in the brain of Down Syndrome patients.
- CCR5 expression is regulated by the cAMP/CREB-1 pathway and that interference in this pathway affects endogenous CCR5 transcription.
- CREB is frequently overexpressed in ovarian cancer where it appears to promote cell proliferation
- p-CREB, C/EBPbeta, and CBP are recruited to the CRE of the GnRH-II promoter in a temporarily defined manner to enhance its transcription in JEG-3 and OVCAR-3 cells in response to cAMP
- TORC2 localization and CREB activity in islet cells
- tissue microarray slides containing sections of NSCLC specimens obtained from 310 patients showed a decreased survival duration was associated with overexpression of CREB or p-CREB in never smokers but not in current or former smokers with NSCLC
- The CREB1-linked single-nucleotide polymorphism was associated with significant differential activation in an extended neural network responding to angry and other facial expressions.
- Results show that VRK1 activates CREB and regulates cell cycle progression in the DNA replication period by inducing cyclin D1 (CCND1) expression.
- Data show that RGS13 inhibits CREB-dependent transcription of target genes through disruption of complexes formed at the promoter.
- Sequence analysis of CREB can be a useful diagnostic tool for confirming diagnosis of RTS.
- Reduced CREB phosphorylation (Ser-129) associated with inactivation of GSK3beta by Ser-9 phosphorylation may be the major mechanism underlying PEPCK-C gene suppression by AMPK-activating agents such as biguanide
- BDNF- and seizure-dependent phosphorylation of STAT3 cause the adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB) family member ICER (inducible cAMP early repressor) to bind with phosphorylated CREB at the Gabra1:CRE site.
- These results support the hypothesis that STAT3 and CREB play an important role in leptin signaling pathway that leads to the proliferation of Ishikawa cells, thus establishing a direct association between obesity and endometrial tumorogenesis.
- Expression of recombinant HDAC8 results in decreased CREB activation and CREB mediated gene transcription in response to forskolin application.
- Targeting CREB or NF-kappaB using small-molecule inhibitors, such as KG-501, holds promise as a preventive and/or therapeutic approach for NSCLC.
- CREB signaling is potentiated by enhancers of long-term memory
- a single pathway from PGF(2alpha) receptor to CREB is responsible for inducing MUC5AC overproduction
- Disruption of CREB transgene activity affects murine brain reward processes using intracranial self-stimulation (ICSS) and inducible bitransgenic mice with enriched expression of transgenic CREB in forebrain regions.
- RGS17, an overexpressed gene in human lung and prostate cancer, induces tumor cell proliferation through the cyclic AMP-PKA-CREB pathway.