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Validated All-in-One™ qPCR Primer for CENPC(NM_001812.4) Search again
Product ID:
HQP151451
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
CENP-C, CENPC1, MIF2, hcp-4
Gene Description:
centromere protein C
Target Gene Accession:
NM_001812.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq].
Gene References into function
- CENP-C may target the centromere by establishing multiple contacts with both the DNA and protein constituents of the kinetochore
- the interaction between CENP-B and CENP-C may be involved in the correct assembly of CENP-C on alphoid DNA
- CENPC target sites that can be sumoylated by SUMO-2 were shown to be equally susceptible to SUMO-1 attachments which include specific sites on SUMO-2 itself, Ubc9, and the recombinant CENP-C fragments
- a functional interplay between the chromosomal passenger complex and CENP-C.
- Using protein truncation and in vitro mutagenesis, we have identified the nucleolar localization sequences on CENPC1,and evidence shows that CENPC1 is an RNA-associating protein that binds alpha-satellite RNA by an in vitro binding assay.
- CENP-C and CENP-H co-localize to the CENP-A chromatin domain.