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Validated All-in-One™ qPCR Primer for BMX(NM_203281.3) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC (MIM 600583), TXK (MIM 600058), ITK (MIM 186973), and BTK (MIM 300300). All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain.[supplied by OMIM].
Gene References into function
- BMX/Etk is a TNFR2-specific kinase involved in TNF-induced angiogenic events
- Etk activation is essential for transducing the EGF-induced apoptotic signaling in breast cancer cells.
- Pim1 and Etk are required for IL6-induced activation of androgen receptor-mediated transcription in prostate cancer.
- Bmx is a downstream Rap1 effector in VEGF-induced endothelial cell activation.
- two isoforms of Pim-1 kinase may regulate distinct substrates and the 44 kDa Pim-1 may play a more prominent role in drug resistance in prostate cancer cells and interact directly with tyrosine kinase Etk/BMX
- Etk transgenic mouse model may be a useful tool for studying the functions of Etk and identification of new molecular markers and drug targets relevant to human diseases.
- Role of Bmx in ischemia-mediated arteriogenesis/angiogenesis: response to ischemia, enhanced in transgenic mice.
- results demonstrate that Bmx is a critical downstream target of the constitutively active PI 3-kinase in PTEN-deficient PCa cells and further show that Bmx is recruited by the EGF receptor and ErbB3 and activated in response to their respective ligands
- Mechanisms regulating IL-6 production led to the discovery that the Tec kinase bone marrow tyrosine kinase gene in chromosome X (Bmx) regulates Toll-like receptor 4-induced IL-6 production.
- Etk/Bmx may have different biological roles in tumor and nontumor cells, and may be involved in regulating hepatocyte differentiation by c-Fos activation in HCC.
- In fibroblast-like synoviocytes of rheumatoid arthritis patients, Etk is implicated in the cross-talk between focal adhesion kinase (FAK) and myeloid differentiation factor 88 (MyD88) pathways.
- Bmx kinase activity in fibroblasts from rheumatoid synovium is increased following LPS stimulation; Bmx is involved in the regulation of LPS-induced IL-6 and VEGF production via mRNA stabilisation.
- Pretreatment of umbilical vein cells with a pharmacologic inhibitor of Bmx, LFM-A13, produced significant radiosensitization of endothelial cells measured by clonogenic survival analysis and apoptosis.