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Validated All-in-One™ qPCR Primer for ATP1A1(NM_001160234.2) Search again
Powered by BiozBy default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq].
Gene References into function
- Atp1a1 activity in VSMC and REC cells of rats, dog, and human show that Atp1a1 does not mediate the involvement of ouabain in the development of hypertension in rats, suggesting that the pathogenesis of human and rat hypertension may differ.
- A search for potential cation binding sites involved calculation of the valence expected from the disposition of oxygen atoms in the models. This identified 3 positions for Na+ & 2 for K+ at which high affinity for the respective cation is expected.
- hypoxia decreases Na,K-ATPase activity in alveolar epithelial cells by triggering its endocytosis through mitochondrial reactive oxygen species and PKC-zeta-mediated phosphorylation of the Na,K-ATPase alpha(1) subunit
- data suggest that activity is reduced in the microvillous membrane of placentas from IUGR pregnancies; changes might impair function of Na(+)-coupled transporters and contribute to reduced growth of fetuses
- sequence 442GDASE446 in the ATP binding pocket of Na/K-ATPase is an important motif and is involved in both the high and low affinity ATP effects rather than in free Mg2+, Na+, and K+ effects
- At high altitude, the amount of mRNA of Na-K-ATPase, CFTR, and beta-actin of brush biopsies did not change in controls but decreased significantly in high altitude pulmonary edema-susceptible subjects
- In the control subjects the Na,K-pump isoform alpha1 was increased by 37% in resistance trained compared to untrained leg, and in the diabetics the alpha1 content was 45% higher in resistance trained compared to untrained leg.
- Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function.
- Decreases in erythrocyte membrane Na(+)K(+) ATPase activity is associated with rheumatoid arthritis
- N-glycans linked to the beta2 subunit of the Na,K-ATPase contain apical sorting information, and the high abundance of the beta2 subunit isoform along with the absence of the beta1 subunit, is responsible for the unusual apical location of the Na,K-ATPas
- Mice with the ouabain-sensitive "human-like" alpha1 isoform developed ACTH-induced hypertension to greater extent than WT animals
- Phosphorylation of AP-2 mu2 subunit is essential for Na+,K+-ATPase endocytosis in response to a variety of signals, such as dopamine or reactive oxygen species.
- after an ischaemic insult, alpha1 and beta1 protein subunit abundance and mRNA levels are independently regulated.
- identified a well conserved Na,K-ATPase catalytic alpha-subunit motif that binds to the inositol 1,4,5-trisphosphate receptor and can trigger an anti-apoptotic calcium signal.
- Na, K ATPase alpha subunit is associated with the Na, K ATPase beta3 subunit on the red blood cells.
- Elevated Na+ -K+ -ATPase activity postexercise may contribute to reduced fatigue after training.
- study reports the association of human ATP1A1 (P<0.000005) and Dear (P<0.03) with hypertension in a relatively isolated, case/control hypertension cohort from northern Sardinia
- 31KKE in H1 and 47HRK in H2 of the Na,K-ATPase have distinct roles in modulating the enzyme's conformational transitions during the catalytic cycle of the enzyme
- after the 4-wk sprint training period, the expression of the muscle Na+-K+ pump alpha1-subunit and Na+/H+-exchanger isoform 1 was higher
- Data show that JNK modulates the effect of caspases and NF-kappaB in the TNF-alpha-induced down-regulation of Na+/K+ATPase in HepG2 cells.
- Ankyrin facilitates intracellular trafficking of alpha1-Na+-K+-ATPase in polarized cells.
- Moderate apoptotic cell shrinkage may be associated with both an increase in K(+) channel permeability and inhibition of the pump whereas more remarkable shrinkage occurs presumably due to inhibition of the pump.
- HEXIM1 may participate in tissue-selective determination of glucocorticoid sensitivity via direct interaction with GR at least in certain gene sets including atp1a1 and scnn1a.