|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for ASCL1(NM_004316.4) Search again
Product ID:
HQP149983
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ASH1, HASH1, MASH1, bHLHa46
Gene Description:
achaete-scute family bHLH transcription factor 1
Target Gene Accession:
NM_004316.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding.
Gene References into function
- HASH1 mRNA expression levels in SCLC clinical samples were 1,000-fold higher than in the NSCLC samples, and this method could contribute to diagnosis based on molecular profiling of tumors.
- We also studied the proneural HASH-1 gene and identified a heterozygous nucleotide substitution in three CCHS patients
- HASH1 appears to be important in the endocrine phenotype of medullary thyroid carcinoma (MTC) tumors and may serve as a molecular target for the treatment of patients with MTC.
- ASH1 is a neuroendocrine marker whose expression is largely conserved in normal and neoplastic pituitary cells.
- the hASH1 mRNA level might represent a useful tool for distinguishing esthesioneuroblastoma from poorly differentiated tumors of the sinonasal region
- Up-Regulation of ASCL1 is associated with gastrointestinal neuroendocrine carcinomas
- The present genetic data may thus suggest that polyglutamine length polymorphisms in ASCL1 could influence predispositions to PD through the fine-tuning of LC integrity.
- RaF-1 activation causes cessation of hASH-1 expression
- Upregulation of ASCL1 and inhibition of Notch signaling pathway characterize progressive astrocytoma
- Knockdown of ASH1 gene in lung neoplasm cells in vitro suppressed growth by increasing apoptosis.
- In prostate cancers with neuroendocrine differentiation...hASH1 transcript levels in androgen deprivation-treated compared with untreated patients
- ASH1 functions as a dual transcription factor by activating neuroendocrine differentiation markers and also repressing putative tumor suppressors.
- lack of nuclear expression of HES1 may contribute to the abundance of ASCL1 and to tumorigenesis in the endocrine pancreas.
- The Ascl1 cell lineage generates Purkinje cells, deep cerebellar nuclei interneurons and oligodendrocytes at specific stages in the transgenic mouse cerebellum.
- Tumor marker mASH1 was highly (sensitivity of 71%) and specifically (specificity of 95%) expressed in poorly differentiated neuroendocrine carcinoma.
- MASH1 is a useful adjunct marker for differentiating small cell carcinoma of the lung from Merkel cell carcinoma.
- Findings suggest that a broad range of SCLC cells has tumorigenic capacity rather than a small discrete population. Intrinsic tumor cell heterogeneity, including variation in key regulatory factors such as ASCL1, can modulate tumorigenicity in SCLC.