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Validated All-in-One™ qPCR Primer for ARSB(NM_000046.5) Search again
Product ID:
HQP149958
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
ASB, G4S, MPS6
Gene Description:
arylsulfatase B
Target Gene Accession:
NM_000046.5(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Arylsulfatase B encoded by this gene belongs to the sulfatase family. The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. The protein is targetted to the lysozyme.
Gene References into function
- Mucopolysaccharidosis type VI: Structural and clinical implications of mutations in N-acetylgalactosamine-4-sulfatase
- Seven novel mutation were identified in ARSB in mucopolysaccharidosis type VI patients undergoing a Clinical trial of enzyme replacement therapy, 3 of these mutations resulted in truncated proteins.
- analysis of novel mutations on the arylsulphatase B gene in South American Mucopolysaccharidosis type VI patients
- Decreased arylsulfatase B activity is associated with cystic fibrosis
- The identification of many novel mutations unique to individuals/their families highlighted the genetic heterogeneity of the mucopolysaccharidosis VI disorder.
- Novel mutations in arylsulfatase B is associated with mucopolysaccharidosis VI
- modification of expression of the lysosomal sulfatases ASB and GALNS regulates the content of CSs.
- Reduced activity of arylsulfatase B enzymatic activity in children with cystic fibrosis
- All the ARSB mutations studied had a significant effect on enzyme activity, protein processing and/or mRNA stability.