|
ORF cDNA clones
|
CRISPR / TALEN
|
Lentivirus
|
AAV
|
TALE-TF
|
ORF knockin clones
|
|
Antibody
|
Proteins
|
miRNA target clones
|
qPCR primers
|
shRNA clones
|
miRNA products
|
Promoter clones
|
Validated All-in-One™ qPCR Primer for ARF1(NM_001658.4) Search again
Product ID:
HQP149836
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
PVNH8
Gene Description:
ADP ribosylation factor 1
Target Gene Accession:
NM_001658.4(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport.
Gene References into function
- A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling
- ARF1 has a role in phospholipase D activation by the M3 muscarinic receptor
- human ARF tumor suppressor binds to Tat-binding protein-1 and has a role in control of cell proliferation
- Overexpression of SPN causes activation of the tumor suppressor protein ARF1.
- crystal structure of the ARF1*GDP*Sec7*Brefeldin A (BFA)complex shows that BFA binds at the protein-protein interface to inhibit conformational changes in ARF1 required for Sec7 to dislodge the GDP molecule
- Results from NMR experiments presented on ADP-ribosylation factor 1 (Arf1).GDP and Delta17Arf1.GDP in solution reveal substantial structural differences that can only be associated with N-terminal truncation.
- GDP-bound ARF1 induces dissociation of ADRP from the Lipid droplet surface;.
- Binding of Arf1 to phosphatidylinositol (4,5) bisphosphate can promote the nucleotide exchange process and facilitate activation of Arfs with associated conformational changes and possible alteration in position and stability of Arf1 N-terminal helix.
- Arf1 mRNA is a natural target for Stau1-mediated decay, and data indicate that other mRNAs are also natural targets.
- These studies suggest that membrin recruits Arf-1 to the early Golgi and reveal distinct kinetic cycles for Arf-1 at early and late Golgi determined by different sets of Arf regulators and effectors.
- The ADP-Ribosylation Factor 1 acts as a master regulator of Golgi structure and function through the recruitment and activation of various downstream effectors.
- CTLA-4 may be stored in a specialized compartment in regulatory T cells that can be triggered rapidly for deployment to the plasma membrane in a phospholipase D- and ADP ribosylation factor-1-dependent manner
- MdmX can affect post-translational modification and stability of Mdm2 and p53 activity through interaction with ARF
- Analysis of the four possible conformations of the human ARF1 N-terminal peptide by molecular dynamics simulations to distinguish which of the four possible membrane bound structures was the most likely.
- N376 to D mutation in the conserved NPxxY motif within the carboxy terminal tail domain (CT) of the 5-HT2A receptor alters the binding preference of GST-fusion protein constructs of the CT domain from ARF1 to an alternative isoform, ARF6.
- A phosphatidylinositol-3-kinase-dependent signal transition defines the sequence of ARF1 activation during phagocytosis.
- Data show that the architecture of the vimentin cytoskeleton is modified by perturbation of the GTPase ARF1.
- Arf1-GTP-ASAP1 undergoes a significant conformational change when transitioning from the ground to catalytically active state
- Coatomer is linked to the Golgi through multiple interfaces with membrane-bound Arf1-GTP.
- Enhanced the stimulatory effect of 1-Phosphatidylinositol 4-Kinase on regulated exocytosis.
- p24A is a regulator of signal-dependent trafficking that controls ARF1-dependent resensitization of PAR-2
- These results suggest that KIAA1110 is expressed specifically in mature neurons and may play an important role in the secretion pathway as a GEF for ARF1.
- siRNAs demonstrate that GBF1-mediated ARF1 activation is required for efficient MHV RNA replication
- Arf1 and Arf6 were shown to load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix.
- Arf1-GTP induces positive membrane curvature and find that the small GTPase can dimerize dependent on GTP
- Arf1-GTP-induced tubule formation suggests a function of Arf family proteins in curvature acquisition at sites of vesicle budding.
- ARF1 regulates epidermal growth factor-dependent breast cancer cell growth and invasion during cancer progression by controlling the activation of the phosphatidylinositol 3-kinase pathway
- present the structure of a myristoylated ARF1 protein, determined by solution NMR methods, and an assessment of the influence of myristoylation on association of ARF1.GDP and ARF1.GTP with lipid bilayers