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Validated All-in-One™ qPCR Primer for APOE(NM_001302690.2) Search again
Product ID:
HQP149772
(click here to view gene annotation page)
Powered by BiozSpecies:
Human
Symbol:
Alias:
AD2, APO-E, ApoE4, LDLCQ5, LPG
Gene Description:
apolipoprotein E
Target Gene Accession:
NM_001302690.2(click here to view gene page)
Estimated Delivery:
Approximately 1-3 weeks, but may vary. Please email sales@genecopoeia.com or call 301-762-0888 to confirm ETA.
Important Note:
By default, qPCR primer pairs are designed to measure the expression level of the splice variant (accession number) you selected for this gene WITHOUT consideration of other possible variants of this gene. If this gene has multiple variants, and you would like to measure the expression levels of one particular variant, multiple variants, or all variants, please contact us for a custom service project at inquiry@genecopoeia.com.
Summary
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2.
Gene References into function
- An interaction between apoE3 and CNTF occurs with both delipidated apeE3 and apoE3 found within a lipoprotein particle in cerebrospinal fluid. This interaction potentiates the survival-promoting activity of CNTF for hippocampal neurons.
- ApoE inhibits the depolymerization of beta 2-microglobulin-related amyloid fibrils at pH 7.5, possibly by binding directly to the surface of the fibrils and stabilizing the conformation of beta 2-microglobulin in the fibrils.
- Patients with multiple sclerosis and allelic polymorphism of APOE epsilon 4 have a significantly higher progression index of disability and a worse ranked multiple sclerosis severity score than their non-epsilon 4 counterparts.
- APOE polymorphisms in cerebral amyloid angiopathy
- gene polymorphism as a risk factor for cerebral amyloid angiopathy-related hemorrhage.
- PON2*S and apoE4 alleles have interactive effect on the development of the two most common forms of dementias AD and VD, and further support the hypothesis that cardiovascular factors contribute to the development of AD.
- Cellular and secreted levels of apoE are reduced (15 and 30%, respectively, over a 24-h period) by addition of exogenous lactosyl ceramide (LacSer) to cultured macrophages, indicating a proatherogenic role for LacCer.
- polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis
- Polymorphisms do not contribute substantially to the risk of holoprosencephaly
- Both epsilon 4 allele and mutation -219G/T in the promoter are associated with early onset coronary heart disease in Finland.
- APOE does not play an important role in susceptibility to Parkinson's disease, but may play a role in dementia associated with Parkinson's disease
- Association of plasma lipid levels with apolipoprotein E polymorphism in Type 2 diabetes; carriers have increased risk of NIDDM
- The unfavorable effect of ApoE 4 genotype on lipoproteins is not altered by HRT, but ApoE 2 genotype modulates the HDL-ERT association in older women.
- These results indicate that, in fetus, the character and metabolism of HDL, especially of apo E-rich HDL cholesterol, are distinct from those in adults.
- in individuals with age-associated memory impairment APOE E4 allele carriers performed worse on memory; this effect was only observed in females
- There is a higher prevalence of the apo E2 allele in patients with severe aortic valve stenosis
- phenotype is associated with glucose metabolism and cognitive function
- APOE gene polymorphism as a risk factor for the severity of macular edema in Type 2 diabetes mexican patients
- Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells
- Epsilon3-haplotypes containing the promoter allele -219T were associated with reduced amyloid deposition and reduced risk of neuropathologically verified Alzheimer disease as compared to epsilon3-haplotypes containing -219G.
- investigated the effect of APO E gene polymorphism over lipid profile, macular toxicity and clinical manifestations in rheumatoid arthritis and systemic lupus erythematosus patients treated with chloroquine
- no association seen between APOE genotype and time to psychosis in Alzheimer's disease
- In a sample of mostly white, well-educated research participants with Alzheimer's disease, the APOE epsilon 4 allele was associated with shorter survival in men but not in women.
- The relationship between APOE genotype and its influence on memory performance following traumatic brain injury have been demonstrated.
- association between ApoE polymorphism and specific components of visuospatial attention
- ApoE affects the age of onset of Abeta deposition in amyloid precursor protein transgenic mice as well as the level, structure and anatomic distribution of brain Abeta deposits.
- role of alleles in dyslipemia and kidney transplantation
- The presence of one or more epsilon4 alleles of ApoE is a significant predictor for the incidence of delusions in the course of Alzheimer disease
- Comparison of apoE epsilon genotypes in MS patients revealed no significant differences in frequencies between benign & severe septiles. The risk conferred by epsilon4 rose upon comparison of carriage rates in more narrowly defined anti-podal quantiles.
- Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene.
- data suggested that the ApoE epsilon2/epsilon4 genotype might be a susceptibility variant of moderate effect for sporadic idiopathic Parkinson disease in our samples, whereas the ACT gene signal peptide polymorphism might not
- role in amyloid foundation but not amyloid growth in vitro; is a risk factor for AD not due to a pathological gain of function of apoE4 but to a loss of protective function of apoE3
- APOE domain structural requirements for the formation of SDS-stable complexes with beta-Amyloid(1-40)
- apoe4 allele frequency is increased in patients with the temporal variant of frontotemporal dementia compared to non-demented controls
- Apolipoprotein E polymorphism in Northern Indian patients with coronary heart disease: phenotype distribution and relation to serum lipids and lipoproteins
- Regulated expression of gene cluster in mascrophages
- apoE binds to the LDL receptor by interacting with more than one of the receptor ligand-binding repeats.
- role of ApoE3 and ApoE4 isoforms in lipid release from astrocytes
- Apolipoprotein E polymorphism in childhood nephrotic syndrome.
- There is a minor association between BChE-K and early-onset coronary artery disease, especially in the presence of the APOE-epsilon 4 allele
- the response to plant stanol ester ingestion was not influenced by apolipoprotein E phenotype
- E2 allele seems to be a risk factor of frontotemporal dementia but is associated with the lowest risk in Alzheimer's disease.
- APOE allele is not associated with cognitive impairment in normal aging
- The APOE epsilon-4 allele seems to influence the risk of Alzheimer disease by a relatively selective effect on episodic memory.
- Apolipoprotein C-III and E polymorphisms and cardiovascular syndrome, hyperlipidemia, and insulin resistance in renal transplantation
- Apo epsilon4 allele ise predictor for stroke development.
- This protein protects PC12 rat cells against the cytotoxicity of APP.
- Isoforms of apolipoprotein E modulate tissue plasminogen activator-induced clot lysis in an in vitro clot assay system.
- generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells
- APOE has a role in regulating cholesteryl ester uptake by binding to SR-BI in human cells
- effects of the apolipoprotein E (ApoE) genotype and gender on the response to donepezil treatment in Alzheimer's disease
- Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus.
- Contributions of 18 additional DNA sequence variations in the gene encoding apolipoprotein E to explaining variation in quantitative measures of lipid metabolism
- that the epsilon4 allele of apolipoprotein E and the -491A allele are over-represented among individuals who complain of memory difficulties.
- We have retested non-demented 80-year-olds who were participants in the Scottish Mental Survey of 1932, and find that the variation in their non-pathological cognitive change from age 11 to 80 is related to their apolipoprotein E (APOE) genotype.
- Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity
- Effect of long-term hormone replacement therapy on atherosclerosis progression in postmenopausal women relates to functional genotype
- Healthy adult males carrying this genotype were used in the oral fat load experiments.
- the -491AA APOE promoter genotype is associated with elevated brain apolipoprotein E levels, suggesting that the risk for AD may be modulated by the apoE protein level as well as by the apoE protein isoform.
- ApoE2, apoE3, and apoE4 are equally effective in inhibiting aortic smooth muscle cell migration toward platelet-derived growth factor, while apoE3 and apoE2 isoforms are preferred to apoE4 for inhibiting PDGF-stimulated smooth muscle cell proliferation.
- The APOE/epsilon 4 was associated with an increase of plasma lipid levels and with a decrease of systolic blood pressure.
- Hyperlipidemia in APOE*3 Leiden transgenic mice resulted in a significant increase in accelerated atherosclerosis in vein grafts.
- APOE isoproteins are inefficient at complexing with synthetic Alzheimer disease amyloid-beta protein in vitro.
- APOE genotype was evaluated for an association between infant genetic variation and the risk for spina bifida cystica.
- differential effects of apoE3 and apoE4 on HDL metabolism
- involvement of ApoE in the hematogenous route of HSV-1 to the CNS
- the APOE varepsilon 4 allele is a predisposing factor for Alzheimer disease, but not for cerebrovascular disease or vascular dementia
- ApoE varepsilon 4 allele occurs frequently in late-onset Alzheimer disease and we have found similar association in cognitively impaired individuals without clinical cerebrovascular disease
- APOE4,4 is associated with thinning of the microvascular basement membrane in Alzheimer's disease
- data indicated that upstream-stimulatory-factor (USF) might be involved in the basal transcriptional machinery of apolipoprotein E by binding to a non-canonical E-box motif within the proximal promoter
- differences in binding capacity of apolipoprotein E3 and E4 isoforms to lipid emulsions
- effects of apoE genotype and plasma concentration on cholesterol and triglycerides (TG) levels in subjects from five countries: Finland, France, Northern Ireland, Portugal, and Spain
- amyloidogenic effects of apoE4 are exacerbated by polymorphisms in the APOE promoter that enhance apoE production
- findings suggest that the APOE4 carriers are particularly susceptible to the atherogenic effects of smoking; this interaction is particularly clear in hypertensive subjects
- apolipoprotein E epsilon4 haplotype is a predictor for recurrence in ischemic cerebrovascular disease
- compared with all the other APOE genotypes, those carrying the Leu28-->Pro mutation were at a substantially higher risk of developing AD (OR=4.25; 95% CI=1.21-14.97).
- the ApoE polymorphism was associated with higher risk of MI in Russians and Tatars under 45.
- Thus, the present study provides evidence that the efficiency of intestinal absorption and synthesis of cholesterol in humans are not related to the apoE phenotype.
- The APOE epsilon4 allele has a negative effect on the course of MS, and increasing axonal damage may be an important mechanism.
- No significant differences in allele or genotype frequency for APOE gene were detected between patients with myocardial infarction and healthy controls.
- Results demonstrate that apoE4-202 functions even in the presence of clearance-defective apoE2.
- The microenvironments of all 12 lysine residues in intact apoE3 were determined and their relative contributions to heparin binding were examined.
- Apolipoprotein E gene polymorphism has a role in hypercholesterolemia and type 2 diabetes, and affects glomerular filtration rate
- Polymorphism is associated with neurodegenerative diseases, notably Alzheimer disease.
- ApoE is dysregulated in nephrotic syndrome with marked increment in serum. Glomerular apoE is down regulated in focal segmental glomerulosclerosis and may contribute to pathogenesis.
- APOE may play a role in invasiveness of human prostate cancer
- Apolipoprotein E gene polymorphisms are associated with carotid plaque formation but not with intima-media wall thickening.
- Apoe4 affects the outcome of acute brain damage in an isoform-specific fashion (apoE4 > apoE3 = apoE2) and is detected in neurons and astrocytes in the peri-infarct area of genetically engineered mice.
- Increased expression of neuronal apolipoprotein E in cerebral infarction.
- APOE genotype distribution strongly influences serum APOE concentration, not suggesting, at present, a possible role as a biochemical marker for AD, but only as a putative longevity factor.
- In a magnetic resonance spectroscopy study of the non-demented elderly occipital cortex, levels of creatine correlate significantly with age and performance on the Mini-Mental State Examination test in APOE epsilon 4 carriers, but not in the non-carriers
- Discontinuation and poor adherence to therapy with statins is dependent on APO E genotype.
- Apolipoprotein E genotype and heterogeneity at the CETP gene locus have an interactive influence on plasma lipid and lipoprotein levels in children.
- The distributions of ApoE epsilon 2, epsilon 3 and epsilon 4 were similar in both clinical patient groups and in the non-diabetic group and unrelated to progression of disease.
- No differences in ApoE allele or genotype frequencies were observed between schizophrenic patients and controls, except for a possible association between male schizophrenic patients and the ApoE epsilon 2 epsilon 3 genotype.
- sequence variation in the BACE1 or BACE 2 gene is not a significant risk factor for AD; but, a combination of a specific BACE1 allele and APOE epsilon 4 may increase the risk for Alzheimer disease over and above that attributed to APOE epsilon 4 alone.
- HFE and APOE genotypes are different between Alzheimer's disease patients, high cognitive impairment and low cognitive impairment controls.
- The effect of APOE genes on brain MRI measures were studied in subjects with age-associated memory impairment. No APOE effects were observed when analyses accounted for other potential confounding variables.
- Apo e4 allele is associated with impairment of endothelium-dependent arterial dilation in the early stage of Type 2 diabetes
- Lack of an association of apolipoprotein E gene polymorphisms with familial age-related macular degeneration.
- APOE epsilon 2 may be a risk factor for early malaria infection
- The ability of APOE4/4 VLDL to inhibit the antiapoptotic effects of HDL presents a potential mechanism by which the expression of several diseases, including atherosclerosis, is enhanced by the APOE4 genotype
- This review examines key scientific advances which focus on possible therapeutic strategies encompassing the use of apoE in the amelioration of atherosclerosis, based on its direct effects on the vascular wall.
- APOE worked as LPL-inhibitor of the lipolysis activated by APOC2. The binding density of APOE was less for small emulsion surfaces than for large ones.
- Hepatic lipase promoter SNPs are associated with increased HDL cholesterol and, paradoxically, an increased risk of IHD after adjustment for HDL cholesterol, and particularly in individuals with apolipoprotein E epsilon43 genotype.
- Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity.
- inheritance of the APOE epsilon4 allele is associated with increased risk of late posttraumatic seizures
- APOE is not associated with the risk of Alzheimer disease.
- Single nucleotide polymorphisms in the promoter of APOE modify the phenotype of open-angle glaucoma and result in increased optic-nerve damage.
- ApoE e4 allele was associated with a marked reduction in LDL peak particle size and an increased plasma concentration of small dense LDL.
- There was no evidence for an APOE allele effect on thyroid status in males. There was no evidence for an APOE allele effect on hepatitis B virus status (HBV), or for an HBV status effect on thyroid status.
- Variability in apoE-related risk was found in both Alzheimers disease(AD) and non-AD cases, depending on the subgroup /Review/meta-analysis/
- These data may support the importance of Apo E 4 allele in determining postmenopausal spine bone mass.
- apoE inhibits cell migration via cAMP-dependent protein kinase A activation as a consequence of its binding to LRP-1
- ApoE4 allele is not a contributory factor to cholesterol gallstone formation, at least in the Japanese population.
- To determine whether late cognitive decline after head injury is more prevalent among carriers of APOE epsilon 4.
- This study confirmed the risk association between APOE epsilon 4 and AD. The observation that APOE epsilon 4 is associated with mixed dementia reflected the role of AD in the aetiopathogenesis of this condition.
- the epsilon2 allele of the APOE polymorphism is a prognostic risk factor for both the onset and the progression of diabetic nephropathy in Japanese type 2 diabetes.
- In the ApoE4 genotype group, low LDL cholesterol was associated with good performance in the mental arithmetic test, whereas for those without ApoE4 genotype.
- 6 hour postprandial triglyceride values were correlated with fasting triglyceride levels, which showed association with the apolipoprotein E4 allele
- a less organized structure in the C-terminal domain of apoE4 leads to the higher affinity for lipid as compared to apoE3, contributing to its preferential association with VLDL
- In a family based study, the authors consistently found a significantly reduced transmission of allele 2 to newborns affected with intrauterine growth restriction (IUGR); in other words, allele 2 seems protective against IUGR.
- The -219G/T polymorphism may influence triacylglycerol-rich lipoprotein metabolism during the postprandial period
- no relation between APOE gene polymorphisms and Japanese patients with multiple sclerosis
- Longitudinal analysis of several components of memory over a 2-year interval showed a significant Age-by-APOE interaction reflecting a decline in new learning for the > or =60 epsilon4+ group only.
- Accelerated memory decline in Alzheimer's disease with apolipoprotein epsilon4 allele.
- Data show that the apolipoprotein E receptor 2 binding domain of apolipoprotein E is in the 1-165 amino terminal region, whereas the carboxy terminal 230-299 region of apoE is required for efficient initial association with phospholipids.
- possession of epsilon4 does not by itself confer an increased risk of cerebral amyloid angiopathy but may be associated with reduced longevity even in the absence of alzheimer's disease or cerebral haemorrhage
- This study found that APOE promoter polymorphisms and APOC1 insertion alleles were significantly associated with AD.
- These data support the hypothesis that increased levels of apoE may be associated with the pathology of schizophrenia and that antipsychotic drugs decrease apoE levels as part of their therapeutic actions.
- Patient with APOE4 allele has significant increased levels of excitatory amino acid in traumatic brain injury patient.
- No association is observed between the APOE epsilon 4 allele and clinical characteristics of the multiple sclerosis study population.
- neuronal expression of apoE is regulated by a diffusible factor or factors released from astrocytes
- Changes in cerebrospinal fluid apoE concentration occur after traumatic brain injury and may be important in the response of the human brain to injury.
- In a study comparing brains from Alzheimer's patients and controls, it was found that hippocampal apolipoprotein D level depends on Braak stage and APOE genotype.
- In human brain, apoE4 dose correlates inversely with dendritic spine density of dentate gyrus neurons in the hippocampus of both Alzheimer's disease patients and aged normal controls.
- In APOE epsilon 4 carriers in a Finnish population with Alzheimer's disease, HSPG2 A allele may possess an additive risk effect.
- Apolipoprotein E expression increases in fibroblasts during apoptosis, growth arrest and mitosis.
- the ApoE E2 allele is a risk factor for the occurrence of type 2 diabetes mellitus in Chinese general population
- Apo E polymorphism was not found to be associated with maximal oxygen uptake (Vo(2max)) levels either in the sedentary state nor the Vo(2max) response to exercise training
- Apolipoprotein E genotype influences lipid and lipoprotein levels in pregnant women.
- young adult epsilon4 carriers, at genetic risk for late-onset Alzheimer's dementia, had abnormally low rates of brain glucose metabolism
- no significant differences were observed between the frequency of apolipoprotein E epsilon3/epsilon3 genotype and epsilon3/epsilon4 genotype in the control group compared to Alzheimer patients' group
- e*2 allele seems to be associated with the lowest reproductive efficiency and the e*3 allele, with the highest
- In young adults, the APOE epsilon4 allele and cigarette smoking act synergistically, increasing an individual's propensity to have a cerebral ischemic event.
- combined frequency of the apoE alleles in the Malays, Chinese and Indians in Malaysia was 0.058, 0.829 and 0.114 for epsilon2, epsilon3 and epsilon4, respectively
- alpha-helices in receptor-binding region and CT domain of apoE align perpendicular to the fatty acyl chains of the phospholipid bilayer and residues of helix 4 are arrayed in a positively charged, curved helical segment for receptor interaction.
- the increased risk of developing Alzheimer's disease and vascular dementia is similar among Asian Indians with ApoE epsilon4 compared with the Caucasian population
- Using human monocyte-derived macrophages (MDM), we show a significantly greater increase in NO production during immune activation in MDM from APOE4 AD patients compared to normal, age-matched individuals or to AD patients with an APOE 3/3 genotype.
- polymorphism of apolipoprotein E gene is associated with longevity
- ABCA1 is essential for the biogenesis of high density-sized lipoprotein containing only apoE particles in vivo
- There is no linkage between Apo E polymorphism and autism.
- we have now investigated whether the different apolipoprotein E (APO E) genotypes, in pairwise combinations with the MTHFR 677TT or ACE D/D mutation, could lead to an increased risk of leukoaraiosis.
- Apo E genotype affected the increase in aerobic capacity produced by exercise training possibly via undefined effects on nerve and skeletal muscle function
- In our cohort, the APOE genotype does not constitute a risk factor for developing POAG (primary open-angle glaucoma).
- APOE epsilon4 may act by a lower neuronal metabolism as a risk factor for cognitive impairment in normal aging and early prodromal AD.
- Accumulation of potentially pathogenic C-terminal-truncated fragments of apoE depends on the isoform and cellular source. Neuron-specific cleavage of apoE4 is associated with increased tau phosphorylation and may play a role in Alzheimer disease
- Shows normal apoE expression. Neurobiology of human apoE isoforms can now be studied in both normal and post-injury state. All apoE regulatory sequences intact. May explain regional vulnerability of neuronal degeneration in Alzheimer's disease.
- Accelerated brain tissue loss and a higher proportion of lesions evolving into "black holes" therefore provide magnetic resonance imaging evidence for more pronounced tissue destruction in multiple sclerosis patients with APOE-epsilon 4.
- In elderly subjects who carry an APOE epsilon 4 allele, plasma amyloid beta protein levels are positively associated with lacunar infarcts and white matter lesions, whereas in APOE epsilon 4 noncarriers no associations are observed.
- Interactions with APOE genotype, cigarette smoking, and alcohol intake
- analysis of a novel, ABCA-1-independent, positive feedback pathway for stimulation of potentially anti-atherogenic apoE secretion by alpha-helix-containing molecules including apoA-I and apoE
- These findings suggest that ApoE epsilon4 plays no significant role in the development of ICVD and VaD, but that ApoE epsilon2 has a protective effect with regard to the development of ICVD and VaD for Taiwan Chinese below the age of 65.
- apoE deficiency results in: impaired catabolism of VLDL/chylomicron and their remnants; 2) an increased rate of catabolism of LDL apoB-100; 3) reduced VLDL apoB production; and 4) a delayed catabolism of Lp(a)
- Polymorphisms in the APOE promoter are found not to be risk factors for Alzheimer's disease nor are they associated with parenchymal or vascular accumulation of amyloid-beta protein.
- A monomeric APOE carboxyl-terminal domain was engineered and studied.
- The association between the APOE-epsilon4 allele and a reduced risk of AMD (age-related macular degeneration) was established in a large cohort with sufficient statistical power.
- The alleles of apoE appear to have a role in the etiology of AMD, with the epsilon4 allele being protective, whereas the epsilon2 allele appears to have a modifier effect by bringing forward the mean age of disease diagnosis.
- no significant difference when APOE and SCA2 allele frequencies of cases and controls were compared for multiple sclerosis
- These results indicate that oleic acid increases apolipoprotein E secretion from macrophages at a locus involving post-translational glycosylation.
- Results confirm that the apolipoprotein E epsilon 4 genotype is associated with Alzheimer's disease and its cognitive impairment pattern.
- The association of APOE epsilon 4 allele with less favorable outcome in multiple sclerosis is reviewed.
- Analysis of transgenic mice overexpressing human apoE in the liver revealed that apoE was recruited from the circulation to the injured site of the carptod aartery wall.
- ApoE 4 genotype was more frequent in AD (41.4%) than in controls and In AD patients, CYP46*C along with ApoE epsilon4 genotype were associated with a higher cognitive decline at 1-year follow-up.
- Allele transmission in families with autism (apolipoprotein-E2)
- onset, diagnosis, and epidemiology of AD, specifically with regard to the APOE genotype and the interaction of the genotype with (review)
- Apo e iaoproteins might contribute to the pathology of alzheimer disease through several different mechanisms. (review)
- Data show that the apolipoprotein E4 (apoE4) isoform acts to aggravate delayed infarct expansion and peri-infarct reactive astrocytosis in genetically engineered apoE-knock-in mice
- After mild head injury, participants with at least one APOE epsilon4 allele had a significantly decreased performance on neuropsychological tests. APOE genotype may influence the outcome following an MHI.
- The presence of 2 epsilon4 alleles is an important determinant of both plaques & tangles. A putative protective role for the epsilon2 allele in AD may be mediated by reduced plaque burden.
- The APOE-4 allele increases risk and decreases age at onset of PD, an association that may not be dependent upon cognitive impairment.
- The ApoE4 is strongly associated with reduced Abeta42 CSF levels in Alzheimer's disease pts & controls. As no associations of APOE variants with other indexes of AD severity were seen, this may reflect fundamental ApoE involvement in Abeta metabolism.
- Polymorphisms of ApoE, independent of gender or other known factors, may affect serum creatinine levels and predict glomerular filtration rate in healthy persons.
- These experiments demonstrate the roles of Chol and ApoE in the modulation of membrane insertion of APP.
- NMR structure of apolipoprotein E carboxyl-terminal domain
- Results examine the impact of apolipoprotein E genetic variation on fertility in two Ecuadorian populations.
- Apolipoprotein E polymorphism is associated with age of onset in schizophrenia
- The ApoE epsilon4 allele was not related to the disease course of multiple sclerosis or the ApoE epsilon2 to the intensity of demyelination on MRI
- no association of the ApoE genotype with multiple sclerosis disease susceptibility nor clinical and MRI measures could be identified.
- Presence of TNFB*A329G polymorphism in addition to APOE*E4 variant is associated with significantly higher releases of interleukin 8 and tumor necrosis factor alpha, prolonged intubation, and increased transfusion.
- the presence of apoE2/3 genotype, high HDL-cholesterol levels and the absence of apoE3/3 genotype can be regarded as risk factors for superficial fungal disease, especially dermatophytosis.
- APOE may have a role along with HSV1 in dementia [review]
- carotid ultrasound results (intimal-medial thickness and stenosis) were related to three APOE genotypes
- ApoE concentration in combination with the ApoE polymorphism significantly influences serum lipid parameters in hemodialysis patients.
- Our data do not support the hypothesis that the ApoE*4 risk allele is associated with BMD, increased bone loss, or an increased risk of osteoporotic fractures
- The APOE epsilon4 allele is associated with increased risk of obstructive sleep apnea/hypoxia, particularly in individuals under age 65, possibly by affecting brainstem degeneration or adipokine-related ventilatory drive.
- In conclusion, our finding suggests that the MMP3 gene, especially together with APOE 4, may contribute to the development of AD.
- This data confirm a specific effect caused by the presence and amount of ApoE epsilon4 allele and suggest that a susceptibility factor to AD.
- Results indicate that adipose tissue expression of apolipoprotein E is modulated by physiologic regulators of insulin sensitivity.
- The results of the present study offer new insight into how recognition memory is affected by Alzheimer disease , the epsilon4 allele, and the modality of the stimulus to be remembered.
- results confirm the hypothesis that serum ApoE concentration is dependent on ApoE genotype, but do not support the view that it has to be considered a relevant biochemical marker for Alzheimer disease and vascular dementia
- Chronic anxiety is associated with significantly greater decline in problem solving skills in cognitively normal APOE e4 homozygotes.
- apoE increases the rate of HL-mediated phospholipid and triacylglycerol hydrolysis in rHDL
- Results describe the relative roles of apolipoprotein E isoforms in low density lipoprotein receptor (LDLR)- and non-LDLR-mediated very low density lipoprotein (VLDL) clearance.
- The presence of the ApoE epsilon4 allele carried a 19.0-fold risk for developing hallucinations and a 3.4-fold risk for delusions in Alzheimer disease.
- single nucleotide polymorphism +5361, or a SNP in strong linkage disequilibrium, may confer some additional risk for developing AD beyond the risk due to APOE-4; however, the effect independent of APOE-4 is likely to be small.
- impaired recycling of apoE4 could interfere with intracellular cholesterol transport and contribute to the pathophysiological lipoprotein profile observed in apoE4 homozygotes
- Ethnic differences and alterations of serum apoE levels significantly modify the relationship between apoE gene polymorphism and serum lipid variability.
- ApoE-epsilon 4 and butyrylcholinesterase-K variant alleles act synergistically to increase the risk of late-onset Alzheimer's disease, particularly in age group <75 years in Tehran, Iran.
- Apolipoprotein E promoter polymorphisms are unlikely to have a major impact on the pathophysiology of primary open angle glaucoma.
- In a Caucasian population, APOE may have effects on BMD variation in males but not females.
- Mild cognitive impairment subjects with APOE epsilon4 had distinct cognitive & imaging profiles, resembling early Alzheimer patients. APOE4 was associated with greater impairments in memory & functional activities & hippocampal atrophy.
- We conclude that APOE allelic patterns in healthy Kuwaiti blood donors and a smaller group of patients with CH do not satisfactorily predict circulating blood levels of lipids and lipoproteins.
- findings indicate that residues Leu-261, Trp-264, Phe-265, Leu-268, and Val-269 of apoE are responsible for hypertriglyceridemia and also interfere with the formation of HDL
- cell-surface heparan sulfate proteoglycan localizes apoE-enriched remnant lipoproteins to the vicinity of receptors by fast association and dissociation
- These data provide a novel explanation for the apparent AD-protective effect of inheriting an epsilon2 APOE allele, and suggest that optimizing AT enrichment of CNS lipoproteins or devising APOAI mimetics may augment AT efficacy in treating AD.
- Accounted for 15-60% of variability of plasma LDL cholesterol or apoB levels in familial hypobetalipoproteinemia(FHBL). The physiologic bases for the greater effects of apoE in FHBL remain to be determined.
- Family history of dementia is associated with an increased risk of dementia and Alzheimer's disease in a very old population, but only among APOE epsilon 4 carriers.
- the APOE4 allele may have a protective role in children with a history of heavy burdens of diarrhea in their first 2 y of life
- Through the analysis of the common apolipoprotein (apo) E gene polymorphism in large Caucasian population study with the PCR and subsequent restriction analysis, we have identified carriers of mutant allele Arg136-->Ser.
- APOE genotypes strongly influenced cognitive function and decline in worman with cardiovascular disease.
- a significant deficit in prospective memory for epsilon4 allele carriers.
- we did not find APOE associated with ALS risk.
- Apolipoprotein E (apoE) polymorphisms were determined in 165 Saudis
- New role of apoE in cancer as apoE expression is important for the proliferation and survival in apoE-expressing ovarian cancer cells.
- An association of allele epsilon 2 of apoE gene with the maturation of HDL in type IV hyperlipidemia was noted in the study.
- A peptide derived from the low density lipoprotein receptor-binding domain of apoE mediates an efficient, energy-dependent translocation of liposomes across the membrane of primary rat brain capillary endothelial cells.
- a looped-back model of apoE4 is proposed in lipid-bound state, including spherical lipoprotein particles, wherein residues Arg-61 and Glu-255 are proximal to one another
- In addition to the APOE epsilon2/epsilon3/epsilon4 polymorphism, the promoter polymorphisms -219G/T and +113G/C as well as their haplotype modulate lipid and lipoprotein concentrations in middle-aged Finnish men.
- apoE4 inhibits synaptic plasticity following environmental stimulation and that this effect is both isoform- and brain area-specific
- No significant association was detected between the APOE epsilon 4 allele and the rate of decline on measures of specific cognitive functions.
- Effects of APOE genotype on component processes of cognition in healthy, middle-aged adults is consistent with the emergence in adulthood of an APOE-epsilon4 cognitive phenotype.
- The apoE epsilon4 allele is associated with chronic cerebral infarction detected at autopsy in older persons.
- There was no association between the APOE genotype and the cognitive change caused by electroconvulsive therapy in major depressive disorder population as a whole
- possession of an epsilon4 allele does increase risk of Alzheimer's disease in persons with mild cognitive impairment.
- Variant alleles of APOE and APOC3 contribute to an unfavorable lipid profile in patients with HIV, who are therefore at high risk for severe ritonavir-associated hypertriglyceridemia.
- No significant associations between apoE genotype and rectal cancer, survival after diagnosis with colorectal cancer, stage of disease at diagnosis or type of tumor mutation.
- In schizophrenia, there was increased apoE in BA9 and BA46. In bipolar I disorder, increased levels of the apolipoprotein were detected in the caudate putamen and BA9 with a decrease in apoE being measured in BA10.
- APOE*4, allele was associated with increased relative risk for elevated total cholesterol to high-density lipoprotein (HDL) ratios and low-density lipoprotein (LDL. APOE*2 was associated with a lower relative risk for total cholesterol to HDL ratios.
- In this study, variations in the frequencies of the apo epsilon4 allele and the apo E3/E4 and E4/E4 genotypes were found in patients with NIDDM, GN and ADPKD
- like the LDL receptor, LRP prefers lipid-bound forms of apoE, but in contrast to the LDL receptor, both LRP and the VLDL receptor recognize all apoE isoforms
- Relative bioavailability of natural to synthetic vitamin E in apoE4 males was close to the currently accepted biopotency ratio of 1.36:1
- ApoE stimulates protein kinase CK2 autophosphorylation, and this can promote phosphorylation of additional substrates such as tau.
- The antioxidant domain of apoE has been localized to its receptor-binding N-terminal domain; the basic amino acids in this domain are important for protecting low-density lipoproteins against lipid oxidation.
- epsilon4 gene dose is correlated with lower cerebral metabolic rate for glucose in regions of the precuneus and the posterior cingulate, parietotemporal, and frontal cortex
- Findings suggest that the epsilon2/2, epsilon3/4, and epsilon4/4 genotypes have greater early mortality risks.
- Genotype of apo E in diabetic patients did not differ with healthy; E2/3 and E3/4 genotypes tend to have higher levels of triglyceride and cholesterol respectively.
- The APOE*E4 genotype status appears to have a greater deleterious effect on gross hippocampal pathology and memory performance in women than in men.
- APOE epsilon 4 carrier status by itself does not predict cognitive decline or conversion to Alzheimer's disease, indicating that APOE genotyping in patients with mild cognitive impairment may have limited clinical applicability for prediction of outcome.
- These findings suggest that intranasal insulin administration may have therapeutic benefit without the risk of peripheral hypoglycemia and provide further evidence for apolipoprotein E (APOE) related differences in insulin metabolism.
- These findings suggest that the increased brain inflammation in apoE4 mice is related to disregulation of NF-kappaB signaling pathway.
- ability of monocyte-derived macrophages (MDMs) in 42 patients with type 2 diabetes to secrete ApoE
- High-cholesterol subjects that are ApoE-epsilon4 carriers have significantly higher levels of lipid peroxidation as assessed by circulating F2-isoprostane levels.
- variant frequencies of ICAM1, APOE, PPARA and PAI-1 genes in coronary artery disease patients and healthy blood donors; specific arrangement of polymorphic variants which differentiate both groups
- APOE4 does not have a role in development of cognition disorders post-stroke in patients with hypertension
- Data show that Longevity was noted to be positively correlated with epsilon 2 and negatively correlated with epsilon 4 apoE genotypes in the Xinjiang Uighur people.
- Haplotypes of the apo E gene are associated with lobar intracerebral hemorrhage
- apolipoprotein e4 allele works through amyloid deposition and subsequent tangle formation to cause cognitive impairment
- The APOE gene polymorphism is associated with OAG in the Japanese population.
- Patients who possess the apoE3/4 genotype had significantly faster rates of progression of renal failure.
- This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.
- Medium-term survivors after redo CABG have a strong genetic predisposition unrelated to hypercholesterolemia or apoE genotype, leading to more severe coronary artery disease at earlier age.
- Our study shows similar ApoE-epsilon4 genotype and allele frequencies in patients with ischemic cerebrovascular diseases and in control subjects
- APOE epsilon3/epsilon4 genotype in men and APOE epsilon2/epsilon3 in women are associated with increased 30-day mortality in stroke.
- The low frequency of APOE*E4 homozygous individuals in the Italian population prevented verification that extensive metabolizers homozygous for E4 requre higher doses of warfarin.
- Early recognition of severe hypertriglyceridemia in pregnancy may be caused by heterozygosity of this protein.
- We apply an extension to this framework to the original cohort of the Framingham Heart Study for measuring the effects of different Apo-E genotypes on the onset age of various cardiovascular disease events.
- Our study indicates that the apoE epsilon4 carrier status should be considered when CSF P-tau(231P) is evaluated as biomarker candidate of AD in MCI subjects.
- Regulates mesangial cell proliferation by inhibiting or reducing proliferation induced by apo B, implying that apo E has protective effect on kidney, and increasing proliferation under certain conditions.
- only lipid-bound apoE promotes SR-BI-mediated cholesterol efflux and that the amino-terminal region of residues 1-165 of apoE is sufficient for both receptor binding and cholesterol efflux
- The Apo epsilon4 allele seems to predispose carriers with multiple sclerosis to a faster progression of disease
- results show apoE co-localized with amyloid beta in amyloid plaques that lack immunoreactivity with antibodies to N-terminal epitopes of amyloid beta indicating that formation of apoE-amyloid beta complexes may conceal N-terminal epitopes of amyloid beta
- VR22 or a nearby gene influences susceptibility to Alzheimer's disease, and the effect is dependent on APOE status
- APOE*4 allele has an age-dependent association with atherosclerosis, increasing susceptibility among young to middle age Argentine males
- Epsilon 4 allele is more often associated with a lack of response to current antiepileptic drugs in complex partial seizurese.
- apoE does not seem to be a risk factor for incident ischemic stroke
- Neuropsychiatric Inventory symptom-endophenotype-genotype relationships, and taking into account possible confounds by latent variable models, APOE genotype did not correlate with any endophenotype in Alzheimer disease
- APOE2 allele increased in tardive dyskinesia.
- epsilon3epsilon4 and epsilon4 frequencies have a role in development of myocardial infarction in middle-aged people in Spain
- apoE molecules are folded into helical hairpins with the binding region for the low density lipoprotein receptor at the apex of each molecule
- apoE4 and Abeta1-42 may work in concert in neurons to increase lysosome formation while increasing the susceptibility of lysosomal membranes to disruption, release of lysosomal enzymes into the cytosol, and neuronal degeneration.
- Regulation of APOE4 expression modulates risk for Alzheimer's disease.
- Study suggests that both regulatory and structural variations should be considered when evaluating the utility of APOE polymorphisms for predicting dyslipidemia in the population at large.
- The apo e4 allele is associated with impairment of endothelium-dependent arterial dilation in the relatively early stage of female type 2 diabetes
- apoE4 appears to modulate APP processing and Abeta production through both the low-density lipoprotein receptor-related protein pathway and domain interaction
- Parkinson's disease patients who carry the APOE epsilon4 allele develop psychosis earlier.
- Genetic factors, as Apo E genotypes, could allow the early identification of patients who are at a high risk for developing hyperlipidemia after sirolimus treatment.
- apolipoprotein E genotype is not shown to increase risk of ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage in a meta-analysis
- APOE 2 allele was associated with significantly worse reexperiencing symptoms and impaired memory function subjects with combat-related posttraumatic stress disorder population.
- These data suggest that human apoE or fragments containing the receptor-binding domain may contribute to innate immunity to viral infection by direct disruption of viral particles and/or inhibition of viral attachment, thus reducing viral entry.
- The increase in phospholipid transfer protein lipid transfer protein in type 2 diabetes is partly related to the changes in apolipoprotein E.
- APOE has disease-specific effects on BPSD in FTD and PDD/DLB patients, given the reported associations of APOE epsilon4 with aggression (FTD) and of APOE epsilon2 with delusions (PDD/DLB).
- Results indicate that, in addition to lipid content, the assembly state of apoE influences amyloid-beta peptide (Abeta)binding and receptor recognition.
- Apolipoprotein e genotype modifies the phenotype of Alzheimer disease.
- These data provide no evidence of a strong association between the APOE gene and early ARM (age-related maculopathy) in middle-aged persons.
- Results showed a gene-gene interaction between the ApoE and the CETP loci in determining HDL-C concentrations.
- Review. Apo E, a multifunctional protein with central roles in lipid metabolism & neurobiology, has 3 common isoforms with different effects on lipid homeostasis. ApoE4 is associated with higher risk of Alzheimer disease & neurodegenerative disorders.
- Significant interaction between cholesterol, APOE-epsilon4 and the risk of Alzheimer disease in the Yoruba.
- The contribution of the epsilon4 allele towards lowering CRP levels is independent and may be by a different mechanism than how statins affect inflammation.
- Individuals with an epsilon (epsilon)2 genotype of the apolipoprotein (APOE) gene were found to be strongly associated with disease with a significant 4.8-fold increased relative risk compared to individuals with an epsilon4 genotype.
- ApoE polymorphism is related to coronary disease in the Chinese Han population, with smoking and alcohol drinking increasing the genetic predisposition to disease.
- In multiple sclerosis APOE epsilon4 polymorphism is not associated with a more severe clinical course and does not appear to influence recovery of exacerbations.
- ApoE level in tumorous tissues is frequently elevated and may be a good histological marker for hepatocellular carcinoma .
- There is considerable effect of the choline acetyltransferase polymorphisms on Alzheimer's disease in Korean population and this effect is dependent on ApoE genotypes
- Delusion symptoms are associated with ApoE epsilon4 allelic variant at the early stage of Alzheimer's disease with late onset.
- Our studies suggest that AEC I is not just a simple barrier for gas exchange, but a functional cell that protects alveolar epithelium from injury.
- X-ray diffraction analysis of apolipoprotein E-containing lipoprotein particles
- The association between variation in the APOE gene and plasma C-reactive protein was shown.
- Active plasma phospholipid transfer protein is associated with apoA-I- but not apoE-containing lipoproteins.
- 24(S)-hydroxycholesterol induces apoE-mediated efflux of cholesterol in astrocytes via an LXR-controlled pathway
- APOE promoter polymorphisms -219G/T and +113G/C as well as their haplotype are associated with longitudinal changes in LDL-C and total cholesterol concentrations in young Finnish males.
- The structural functional characteristics of two full-length and truncated apoE3 and apoE4 tailored to eliminate helix and domain interactions are reported.
- Although the harmful effect of APOE4 on episodic memory was modest in women, the risk was found to occur in about 30%. APOE4 was observed to have a dramatic effect on episodic memory in men, but only in homozygotes
- Involvemenet of this allele is still unknown, but increased genetic risk for developing Alzheimer disease is associated with changes in microscopic white matter integrity well before the onset of dementia.
- ApoE gene status (presence or absence of Apo E4) has minimal influence on lipid profile characteristics except for low density lipoprotein (LDL) in Alzheimer's disease.
- performance on neuropsychological tasks that are presumed to be related to temporal lobe, frontal lobe and white matter integrity is worse in patients with the APOE epsilon4 allele than in those without it
- Polymorphism is not positively associated with type 2 diabetes in an Indian population.
- APOE HhaI polymorphism may not be associated with gallstone disease
- ApoE epsilon2 carriers have an increased risk of intracerebral hemorrhage in brain arteriovenous malformations.
- A meta-analysis of APOE genotypes does not support a role for APOE in multiple sclerosis.
- This study provide indicates the influence of ApoE genotype on implicit learning even in healthy older individuals without cognitive impairment.
- Unspecified factor embodied in first-degree family history of Alheimer disease is influencing the expression of APOE4 on brain function.
- for E2/2 subjects, lipoproteins isolated in the LDL density range appear to be composed mainly of dense IDL remnants and some Lp(a). The apo E isoform also has a significant effect on LDL concentration in both homozygotes and heterozygotes
- the epsilon2 apolipoprotein E genotypes may have a role in inducing breast cancer in patients in pre-menopause
- The frequency of ApoE epsilon4 allele carriers was significantly overrepresented in Alzheimer disease group compared with Vascular Dementia.
- Intravenous administration of AAV2/7- and AAV2/8-apoE vectors effectively mediated robust and sustained hepatic-specific expression of apoE and completely prevented atherosclerosis at 1 year.
- Possession of an epsilon 4 allele influences the likelihood of exhibiting an exaggerated pupil response and the absolute overall magnitude of the response. Allelic variability also correlated with cognitive impairments in memory and attention.
- APOE genotype may influence the cognitive phenotype of PD, and specifically that absence of the epsilon4 allele is associated with working memory impairment.
- Our findings suggest that the APOE epsilon 4 allele confers a protective effect against NTG, whereas the APOE promoter polymorphisms do not contribute to POAG risk. However, the APOE -219G carriers tended to have later-onset POAG.
- Estrogen receptor alpha and APOEepsilon4 polymorphisms interact to increase risk for sporadic AD in Italian females.
- Fasting lipids were measured by usual methods and Apo E genotype was established in French patients with type 2 diabetes.
- APOE epsilon3/epsilon3 genotypes were significantly decreased in diabetic nephropathy.
- ApoE genotype was determined using the CardioVascular Disease (CVD) StripAssay. The prevalence of genotypes E3/3, E3/4, and E2/3 was found to be 69%, 26%, and 22%, respectively, and 0.6% for each of E2/4 and E4/4 genotypes.
- AD patients who carry the ApoE epsilon4 allele are at greater risk than noncarriers for developing psychotic symptoms, particularly as the severity of their dementia progresses.
- APOE genotype is unlikely to have a clinically significant effect on warfarin dose requirements.
- Romany and Slovakian populations differ in ApoE genotype; no effect of ApoE polymorphism on lipid levels in Romany subjects was determined.
- The interaction was stronger in the middle-aged than in the older participants. There was a trend for individuals with combined APOE-epsilon4/CHRNA4 TT genotypes to show both lower white matter volume and slower overall RT on the attention task.
- the protective effect of apoE2 seen in African Americans could be explained by a favorable lipid profile in epsilon 2 carriers; in Caucasians, the absence of this protective effect could be due to the lack of effect of apoE2 on the lipid profile
- applied a genetic-demographic approach to a dataset relevant to two genes, APOE and HSP70.1, previously shown to be related to longevity by the gene-frequency method
- ApoE allele carriers have differential cerebral blood flow immediately after injury that may affect outcomes in the traumatic brain injured population.
- The present prospective study indicates that the epsilon4 allele of the Apo E polymorphism is one of the prognostic risk factors involved in the development of diabetic nephropathy with type 2 diabetes mellitus.
- There appears no interaction between cerebrovascular disease and APOE epsilon4 on cognitive decline in very old people
- The presence of the ApoE4 allele was significantly associated with a worse MMSE score evolution (P=0.04).
- APOE epsilon4+ (epsilon4+/epsilon4 + or epsilon4+/epsilon4-) genotype is more frequent in Alzheimer disease and Lewy body dementia.
- findings suggest an association between the apolipoprotein E3 gene variant and an elevated risk of alcohol withdrawal seizures
- These results indicate that cortical acetylcholineesterase activity is relatively well preserved in apolipoprotein E4 carriers, either by preservation of its cellular expression or as AChE activity in amyloid plaques.
- LRP binds and endocytoses Abeta42 both directly and via apoE but endocytosed Abeta42 is not completely degraded and accumulates in intraneuronal lysosomes
- With respect to hippocampal neurons, the apolipoprotein E polymorphism does not modulate the original formation of dendrites in vivo, contrary to conclusions drawn from in vitro studies on neurite outgrowth.
- Regionally reduced gray matter density is detectable in cognitively intact adults with a single copy of the APOE epsilon4 allele.
- We propose that the differential regulation of mortalin in AD and by the APOE genotype is a cellular defense mechanism responding to increases in oxidative stress.
- There was a clear association between apolipoprotein E polymorphism on lipid-lowering response to treatment with atorvastatin and fenofibrate in patients with different types of dyslipidemia.
- results confirmed that the APOE4 allele occurs frequently in late onset Alzheimer's disease compared with normal controls
- analysis of the LDLR recognition properties of apoE
- These observations may give insight into the etiology behind the increased risk for AD associated with the ApoE-epsilon4 allele and the pathogenesis of vascular Abeta deposition.
- Individuals with a family history of AD and the APOE epsilon4 allele, additional genetic or environmental factors may accelerate the onset of dementia.
- ApoE epsilon4 allele should be screened in patients with femoropopliteal atherosclerosis
- ApoE polymorphism appears to be associated with variance of the lipoprotein phenotype in Chinese families with familial combined hyperlipidemia.
- Therefore it is concluded that HMW-adiponectin may ameliorate dyslipidaemia by reducing the hepatic release of ApoB and ApoE, whereas ABCA1 function and ApoA-I secretion are not influenced.
- data suggest a role of vascular wall apoE3 to balance the intracellular redox state in injured endothelial cells via NO-dependent pathways
- APOE epsilon 4 may function to accelerate thinning in areas found to decline in aging (medial prefrontal and pericentral cortex).
- study reports that African American apo E2 carriers, compared with E3 or E4 carriers, had lower allele-specific apo[a] levels for large apo[a] sizes
- The sexual abuse scale were negatively associated with memory performance. Furthermore, the epsilon4 allele of the apolipoprotein E gene interacted with sexual abuse scores to result in reduced memory test performance.
- This review analyses the influence of apo E polymorphism on blood lipids and coronary heart disease in respect to age.
- In the Ouro Preto, Brazil, admixed population the presence of APOE *2 can confer a protective effect, whereas the presence of APOE *4 implies an enhanced risk for dyslipidemia.
- Apolipoprotein E epsilon4 allele is associated with Parkinson disease risk in a Mexican Mestizo population.
- apoE4, but not apoE3, in macrophages enhances atherosclerotic plaque development in an LDLr-dependent manner
- detection of fourth allele (epsilon3r) in a Caucasian patient with motor neuron disease
- findings provide continued support for the negative impact of the epsilon4 allele on cognition and further suggest that speed-of-processing during memory tasks may have the potential to detect subtle cognitive deficits
- We conclude that APOE is influencing the risk of dementia in persons with DS.
- The ApoE-epsilon4 allele interacts with longstanding seizures to affect memory performance, both verbal and nonverbal, in patients with medically intractable temporal lobe epilepsy.
- Coronary artery disease is associated with Alzheimer disease neuropathology in APOE4 carriers.
- Evidence from these analyses supports current literature refuting the notion of relatively poorer neuropsychological functioning associated with the APOE-epsilon4 genotype among young adult participants shortly following mild or moderate brain injury.
- The data suggest that neurophysiological endophenotype of non-demented individuals at genetic risk for AD, characterized by increased excitability and dysfunction of deep brain and alpha rhythm-generating structures.
- An association with the epsilon4 allele in multiple sclerosis was evident in this study, but only in cases of severe cognitive impairment.
- an association of APOE promoter polymorphisms (A-491T, T-427C) with an ischaemic stroke is shown in individuals of Yakut ethnicity
- The apoE4 allele influences osteocalcin gamma-carboxylation in hemodialysis patients.
- The study suggests an association between the ApoE epsilon4 allele and the late-onset depression without cerebrovascular disorders.
- Combined with abdominal obesity, epistasis in the VLDL pathway (lipoprotein lipase, apolipoprotein CIII, hepatic lipase, PARalpha, PPARgamma, and apo E genes) has a deleterious effect on fasting triglycerides and coronary artery disease risk profile
- Reduced task-associated MTL activation that does not correlate with either visuospatial perspective or task performance suggests that MTL dysregulation occurs prior to clinical symptoms of dementia in APOE*4 carriers.
- ApoE elicits isoform-dependent effects on macrophage TNF-alpha and IL-6 expression as well as secretion.
- In females, epsilon4 homozygosity confers a risk of shingles and also of infectious mononucleois, and the APOE-epsilon4 allele is protective against post-herpetic neuralgia whereas APOE-epsilon3 allele is a risk.
- APOC3 polymorphisms were associated with lipid variables, but the magnitude of these associations was modulated by additional genetic, biologic and/or environmental factors.
- Higher APOE epsilon4 allele frequency was observed in AD patients compared to VaD and/or NoCI subjects, while no differences were found between VaD patients and subjects with NoCI; lower APOE epsilon3 allele frequency was observed in AD patients.
- study confirmed the association between APOE-epsilon4 and white matter hyperintensity
- This multiplex PCR technique can be carried out in a single tube and can differentiate between the three polymorphic sites of this gene associated with Alzheimer's disease.
- In contrast to previous smaller studies, apoE polymorphisms were not associated with susceptibility to cholesterol gallstone disease in high-risk populations.
- APOE epsilon4 allele appears to significantly impact rate of volume loss over time in the hippocampus in nondemented older adults; detailed cognitive characterization is necessary to interpret the relationship between cognition and brain structure.
- The allele variability in the -516C/T polymorphism in the APOB gene promoter may partly explain the interindividual differences in postprandial lipemic response in healthy subjects.
- Angiotensin I converting enzyme and APOE4 polymorphisms are risk factors in late onset Alzheimer disease.
- The ApoE4 allele constitutes a risk factor for hippocampal volume loss in patients with alcohol dependence under the conditions of hyperhomocysteinemia.
- occurrence of the epsilon2 allele and epsilon2epsilon3 genotype may be protective against development of nonalcoholic fatty liver disease.
- The researchers found an association the presence of the epsilon2allele and epsilon2epsilon3 genotype and a lower risk of myocardial infarction compared to the epsilon3epsilon3 genotype.
- degree of linkage disequilibrium for a comprehensive set of 50 SNPs in and surrounding APOE using a substantial Caucasian sample of 1100 chromosomes
- APOE epsilon 4 is significantly associated with cognitive impairment in patients with multiple sclerosis
- in old age, except for epsilon2-allele carriers, high plasma apoE levels are associated with a higher risk of stroke, independent of APOE genotype, plasma levels of lipids, and other cardiovascular risk factors
- in old age, in non-epsilon2-allele carriers, high plasma apoE levels are associated with cognitive impairments, independent of genotype, cardiovascular risk factors, and stroke
- In the Stanislas Family Study, epsilon4 allele of the APOE gene was associated with lower hs-CRP concentration, but not with 5-year changes.
- These data suggest that a cooperative mechanism involving APOE and APH-1b plays a role in the susceptibility to develop AD.
- This study provides empirical support for the suggestion that the APOE locus is the major susceptibility gene for late-onset AD in the human genome, with an OR significantly greater than any other locus in the human genome
- The e4 allelic frequency was 8% in the nephropathy group versus 25.9% in the control group. Apo e3 allele and E3/3 genotype frequency were higher and E3/4 genotype was lower in the nephropathy group than in controls.
- apoE*E2 allele occurred with lower and the epsilon4 allele with higher total and LDL-chol. In adulthood, apoE phenotype-related difference in HDL-chol, and the epsilon2 allele occurred with higher and the epsilon4 allele with lower apoA-I and HDL-chol.
- We found no significant difference in RNFL thickness at the optic disc in the different genotype carriers of the APOE and CHRNA4 genes, and thereby no evidence for increased loss of ganglion cells in the retina as an effect of these genes
- Cortical thickness of the left entorhinal region was thinner in epsilon4 carriers than in non-epsilon4 carriers and cortical thicknes with epsilon4 carriers having the thinnest cortex and epsilon2 carriers the thickest, with epsilon3 homozygotes.
- There was an effect of APOE epsilon4 on the object recognition and spatial navigation tests in healthy elderly persons, with non-epsilon4 carriers outperforming epsilon4 carriers, but not in the other cognitive tests
- The findings of this study are unique in that they address not only the relationship between APOE 4 allele presence and outcome from severe TBI, but also describe differences in trajectory of recovery by APOE 4 allele presence.
- CETP and APOE genotypes account for up to 9% of the variance in HDL-c phenotypes in the HERITAGE Family Study
- If a common pathogenic mechanism exists for the two age-related neurodegenerative diseases, primary open-angle glaucoma and alzheimer disease, it does not involve APOE polymorphisms.
- found a significant increase in the hazard of ischemic heart disease in females with the A560T832/T560T832 genotype that remained significant after fitting the effects of dyslipidemia, other risk factors, and structural isoform variations of the ApoE
- the epsilon4 APOE allele may promote intima-media thickening, interacting with other factors contributing to Alzheimer disease development
- Lower CRP in those with APOE4 may reflect immune effects of the APOE4 genotype.
- These findings show that oxidation of chylomicron-remnant-like particles lowers their rate of uptake and induction of lipid accumulation in macrophages.
- Prolonged exposure of older, nondemented individuals to stress in the presence of an epsilon4 allele leads to memory decline.
- Data indicate that the APOE genotype may be a component in assessing the effectiveness of 17beta-estradiol's action and may impact the neuroprotective role of 17beta-estradiol hormone replacement therapy on brain function when the APOE4 gene is expressed
- analysis of the APOE4 allele in Down Syndrome and its possible role in unsuccessful ageing
- Enhanced hippocampal connectivity with additional brain regions in APOE epsilon4 allele carriers during the performance of an associative memory task
- Apolipoprotein E epsilon 4 was weakly associated with retinopathy in persons without diabetes. Other signs were less consistently associated with APOE polymorphisms.
- The frequency of E4 allele as a genetic risk factor for some multifactorial diseases in the population of Southern Iran is in the lowest reported amounts in the world.
- Apolipoprotein E genotype was not associated with education and did not account for the relationship between education and dementia in a twin study
- Apo E polymorphism does not differentiate familial from sporadic Alzheimer disease.
- the effect of APOE gene variation on risk of AD and rate of cognitive decline and demonstrates that a single SNP captures all of the risk of developing AD but two SNPs in the regulatory region may affect the rate of cognitive decline in AD patients.
- No main effect of APOE in an autism data set.
- Apolipoprotein E4 carrier might be associated with the protection for the development of diabetic nephropathy in type 2 diabetic patients.
- APOE epsilon 4 allele is more frequent in children with obstructive sleep apnea and particularly in those who develop cognitive dysfunction.
- The objective of our study was thus to determine the allele, genotype, and haplotype frequencies at several single nucleotide polymorphisms (SNPs) in the region of ApoE and test their association with OSA status in children.
- Apolipoprotein E affects both myelin breakdown and cognition: implications for age-related trajectories of decline into dementia.
- The exact role of APOE in the pathophysiological process of Alzheimer disease still remains unknown; the APOE gene is the only gene so far recognized as a consistent genetic determinant of sporadic forms of AD [review].
- Macrophage secretion of apoE occurs via a PKA- and calcium-dependent pathway along the microtubule network.
- Impairments in neuroplasticity induced by apoE4 following environmental stimulation cause accumulation of intraneuronal Abeta, suggesting that Abeta mediates the synergistic pathological effects of apoE4 and environmental stimulation.
- Expression of the hApoE transgene was not sufficient to correct hypercholesterolemia. However, lesion area at the brachiocephalic artery (BCA) was significantly reduced (-72%) in female hApoE transgenic mice on the LDLR-/- background.
- This study suggests a role of the APOE gene in the etiology of aneurysmal subarachnoid hemorrhage
- a significant effect of the apoE genotype on total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C)/Total cholesterol (TC) ratio, and triglycerides was observed in a rural South African population
- Among older adults free of clinical cardiovascular disease, specific apo E alleles appear to confer positive associations of alcohol confer associations of alcohol consumption with IL-6 concentrations.
- The prevalence of E3/E3 was lower & that of E4-containing phenotypes was higher in stroke patients. The prevalence of E4-containing phenotypes was significantly higher in ischemic vs hemorrhagic & in small-vessel vs large-vessel stroke.
- The presence of apolipoprotein epsilon4 and epsilon2 alleles augments the risk of coronary artery disease in type 2 diabetic patients.
- Changes of HDL-cholesterol and apo-AI/apo-E mRNA ratio could be a good indicator of liver damage and/or hepatic functional recovery post-orthotopic liver transplantation.
- The relationship between APOE genotype and mortality differs across population groups but shows little evidence of variation within groups.
- HBO2 therapy reduces cognitive sequelae after CO poisoning in the absence of the APOE 4 e4 allele.
- RLP-cholesterol is better associated with, APOE genotype than triglyceride and the effect of the T allele on MTHFR polymorphism (C667T) homocysteine levels is more prominent in men than in women among Japanese
- The aim of this study was to establish the frequency of apoE genotypes in 744 Mongolian subjects and to compare the results with findings from other Asian populations.
- In patients with subarachnoid hemorrhage, the expression of the E4 allele is associated with a higher risk of a negative outcome and delayed ischemia.
- This review discusses the differential effects of human apoE isoforms on anxiety in adult mice lacking apoE and in probable Alzheimer's disease patients.
- Availability of monomeric, biologically active, full-length apoE, allowing high quality NMR structural determination
- This review cites growing evidence of the effect of ApoE on modifying brain inflammatory responses and providing protection from excitotoxic injury, which may be central to its protective properties.
- As compared with E4-, E4+ subjects showed decreased CMRglc in AD-related brain regions and associated higher CSF IP, P-Tau, T-Tau, and P-Tau/Abeta42 levels (p's < .05).
- ApoE4 carrier status was associated with increased risk for early postoperative delirium; results suggest genetic predisposition plays a role & may interact with anesthetic/surgical factors contributing to the development of early postoperative delirium
- no convincing evidence that carriers of the APOE epsilon4-allele have a higher risk of delirium
- present study suggests that ApoE polymorphism significantly affects serum lipid profile in hemodialysis patients and epsilon4 allele carriers are more susceptible to have atherogenic lipid profile
- The epsilon2 allele of the apolipoprotein E gene may have a protective effect against some aging-associated diseases and mortality in oldrer individuals.
- The results are consistent with a close coupling between release of 24S-hydroxycholesterol and apoE secretion under conditions with neuronal degeneration.
- the effects of APOE alleles on gene expression in Alzheimer disease
- epsilon4 allele of APOE is an independent risk factor for metabolic syndrome
- The apoE2 allele was negatively associated with hypertriglyceridemia/hyperapobetalipoproteinemia in the absence of a deleterious LPL gene variant.
- Coronary function improves by 6 months of pravastatin therapy in subjects with the apoE epsilon3/3 genotype, but not in those with the epsilon4/3.
- Regulation of mouse and human APOE genes may be sufficiently unique to justify the use of both the human APOE promoter sequence in transgenic rodent models and non-rodent AD models for studying factors involved in AD pathogenesis
- approximately linear relationship of apoE genotype with LDL-C levels & coronary heart disease risk; compared with individuals with epsilon3/epsilon3 genotype, epsilon2 carriers have lower risk & epsilon4 carriers have a slightly higher risk [review]
- Our data do not support a role for APOE in MS severity, in spite of the seeming influence shown using other measures such as Progression Index.
- The genetic polymorphism of apoE has an independent negative impact on patient and graft survival in kidney transplantation
- ApoE epsilon4 allele may be correlated with severe depression in the elderly through ways other than the "vascular depression" hypothesis
- The APOE epsilon4 allele is associated with hippocampal, amygdalar and entorhinal cortex atrophy; increased brain atrophy; increased white matter hyperintensity volumes; and altered cerebral blood flow and glucose metabolism patterns. [review]
- ApoE is required for HCV virion infectivity and production, suggesting that HCV virions are assembled as apoE-enriched lipoprotein particles.
- Dietary supplements were effective in both normal and mice expressing human ApoE4, one of the three major alleles of ApoE.
- Apo E gene mutations may not be the only etiology of lipoprotein glomerulopathy, and it is likely that other abnormalities could play a role in the pathogenesis of the disease.
- it is concluded that apoE enhances the capacity of PLTP to remodel HDL but reduces the ability of HDL to participate in PLTP-mediated phospholipid transfers.
- Patients with ApoE epsilon4 genotype were more likely to have severe clinical symptomatology and unfavorable neurological outcome after traumatic brain injury compared to significantly better outcome with other ApoE genotype.
- The expression of apo C1 and apo E are closely associated with the susceptibility to the pathogenesis of atherosclerosis
- Findings challenge the commonly held notion that the presence of the APOE epsilon4 allele reduces onset age; findings indicate risk factors other than APOEe4 allele underlie the non-familial, early onset posterior hemisphere presentations of Alzheimer's.
- In female subjects (but not in male) an association between APOE polymorphism and TC was observed on the background of the common APOA5 haplotype (TT-1131/SerSer19).
- There was no association between APOE epsilon4 genotype and aluminum absorption
- Patients with the APOE-in4 allele had a significantly better global functional outcome on the GOS than patients without the APOE-in4 allele.
- To evaluate a possible association between the epsilon polymorphism of the apolipoprotein E gene (apo E) and premature IHD
- findings in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) indicate that E(4) is associated with more-rapid cognitive decline and may, therefore, predispose to dementia
- among dyslipidemic patients, carriers of APOE*4 compared to homozygous carriers of APOE*3 had significantly higher levels of LDL cholesterol and apoB, but no relationship with CAD was found
- APOE gene interacted with gender in predicting severity of acute neurological deficit and post-stroke mortality within the period up to 1 year after the IS.
- Apolipoprotein E2 genotype may contribute a common phenotype of enhanced vascular instability that increases the risk of hemorrhagic outcome.
- APOE isoforms have minimal impact on warfarin dose requirements in Asian patients, probably due to the low frequency of epsilon 4 allele-containing genotypes.
- ApoE4 enhances attachment of C. pneumoniae elementary bodies, but not those of C. trachomatis, to target host cells.
- Alzheimer's disease development is controlled not only by the apoE isoforms but also by the posttranslational modifications in apoE
- Presence of the ApoE-epsilon4 allele modifies the relation between plasma homocysteine and cognitive performance
- Inhibition of CETP reduced the VLDL apoE pool size (-28%) by increasing the VLDL apoE fractional catabolic rate (77%) and leaving the VLDL apoE production rate unchanged
- The present results indicate that the most common ApoE phenotype in Greek demented patients is E3/3.
- apoE (arginine 150 proline) is a novel apoE variant that etiologically related to lipoprotein glomerulopathy
- apoE expression modulates capase-3 activity, but this has no significant impact on sensitivity to apoptosis and only a moderate impact on basal cholesterol efflux.
- Apolipoprotein E genetic polymorphisms/intrauterine undernutrition interaction and hypercholesterolemia in children.
- a probable association between epsilon3/epsilon4 genotype of apolipoprotein E and lacunar infarcts.
- identified receptor-ligand genetic interactions between VLDLR 1226 and APOE genotype for predicting CAAD case status.
- acute myocardial infarction from information on functional gene variants that favor inflammation or modulate cholesterol metabolism: IL6 -174 G/C, TNF -308 G/A, IL10 -1082 G/A, SERPINA3 -51 G/T, IFNG +874 T/A, HMGCR -911 C/A, and APOE epsilon2/3/4
- Apolipoprotein E promoter polymorphisms (-491A/T and -427T/C) and Alzheimer's disease: no evidence of association in the Irish population.
- Results showed that the frequency of APOE epsilon4 allele was significantly higher in the depressed vs non-depressed AD patients (72% and 58%, respectively).
- Our findings argue against a specific role for any APOE alleles in conferring susceptibility to sporadic inclusion body myositis but have demonstrated a non-significant trend towards an earlier age-of-onset in patients with the epsilon2 allele
- Our results show a clear association of APOE with carotid intima-media thickness, even though publication bias means that this is overestimated by the published literature.
- The latitudinal distribution of the APOE epsilon3 and epsilon4 allele frequencies in the populations examined was comparable to the frequency distribution pattern of these alleles in other populations of Eurasia.
- Men with APOE Kyoto mutation are at increased risk for lipoprotein glomerulopathy.
- In the older white population, APOE epsilon2 and epsilon4 allele carriers were more likely to have arterio-venous nicking.
- The specific Apolipoprotein E allele showed higher levels of Matrix Metalloproteinase 9 in epsilon 2 carriers compared to the non- epsilon 2 carriers of the patient group and large artery atherosclerosis subgroup.
- Although the ApoE genotype distribution was not significantly different between gPD patients and controls, the protective E2 alleles were more frequent in controls than in patients without a PFH and even less frequent in those with a PFH.
- Common APOE polymorphism does not seem to be an independent genetic determinant of carotid intima-media thickness, brachial flow-mediated dilatation or carotid artery compliance
- APOE -491AA promoter in epsilon4 carriers is apt to the clinical deterioration and may contribute to the poor outcome after TBI.
- The linkage of Alzheimer's disease to chromosome 19 was well explained by APOE in the whole sample as well as in the UK and USA.
- APOE*2 (apolipoprotein E2) carriers showed a decreased risk of all-cause mortality and APOE*2 allele confers a lower risk of all-cause mortality only to normal weight individuals
- our data suggest that the four analyzed genes do not play an important role in susceptibility to schizophrenia.
- Apolipoprotein E-epsilon 4 carriers had significantly lower levels of C-Reactive Protein yet significantly higher levels of Cytomegalovirus antibodies
- The epsilon2/3 genotype is a major contributor to ADL disability in common geriatric diseases, while providing protective effects for coronary heart disease.
- the apolipoprotein E epsilon2 allele is an important risk factors for neurodevelopmental dysfunction after repair of Tetralogy of Fallot
- To investigate associations of APOE, APOE promoter (G-219T), and tau protein exon 6 polymorphisms (47 and 53) and a history of self-reported concussion in college athletes
- Overweight exhibited an inverse association with APOE4 and associated with decreased non-APOE4 Alzheimer's disease onset age.
- both diabetes and APOE epsilon4 increases the risk of dementia
- The results indicate that the C-terminal domain is organized differently in apoE3 and apoE4 so that apoE4 self-associates less and binds less than apoE3 to HDL surfaces.
- APOE epsilon4 did not increase the risk for AD in this Mexican Mestizo elderly urban population sample, although the presence of this allele seems to modify its clinical expression.
- APOE polymorphism and coffee drinking was associated with Parkinson's disease
- The APOE epsilon2 allele was in linkage disequilibrium with the -427C allele in atherosclerosis diseases, and the -219T allele was associated with the epsilon4 allele in the ischemia heart disease group.
- The results partially support studies of older adults that suggest that increased cognitive asymmetries reflect risk for dementia and are associated with the APOE-epsilon 4 genotype.
- The epsilon4 allele in healthy elderly was associated with increased subjective mental slowing after trihexyphenidyl anticholinergic challenge.
- Hypertriglyceridemia is closely associated with APOE*2 allele and with an early onset of liver cirrhosis.
- The present study suggest the possible influence of APOE on specific cognitive domains (orientation and language domains)
- APOE gene actions may be more significant as modulators of frailty than of longevity.
- In both wild-type and human apoE knock-in mice, apoE-intron3 is found predominantly in cortical and hippocampal neurons by in situ hybridization.
- Carriers of the epsilon 2 or epsilon 4 APOE allele has an increased risk of both incident and recurrent intracerebral hemorrhage (ICH), and both cortical and deep ICH; most risk estimates are higher in Asians than in Europeans.
- Alzheimer's disease structural and biochemical arteriolar abnormalities did not vary as a function of APOE genotype.
- PAI-1 has a role in fatty liver and hypertriglyceridemia in familial combined hyperlipidemia, along with apolipoprotein E
- The data do not support an association between ApoE polymorphism and frailty.
- The researchers found that APOE gene variations were slightly less significant than the Alu polymorphisms in assessing the genetic heterogeneity within the sampled Mediterranean populations
- Children dying from identified causes have different APOE allele distributions from sudden infant death syndrome (SIDS) cases, but are similar to adults. Children dying from SIDS have an allele distribution comparable to healthy newborns.
- Men carrying the G allele of APOE IVS1+69 had a 1.7-fold risk of gallstones, a 1.8-fold risk of gallbladder cance, a 3.7-fold risk of bile duct cancer and a 4-fold risk of ampullary cancer.
- ApoE genotype is not associated with prevalent hypertension in old age.
- The V allele of the GSTP1 may be a risk factor for late-onset Alzheimer's disease, mainly in the presence of the apoE 4 allele, while the presence of GSTT1 may indicate protection against the disease
- genetic variation at the APOE is not a genetic factor related to the genetic susceptibility to coronary artery disease in Mexican individuals
- Apolipoprotein E promoter polymorphism is associated with ischemic stroke and intracranial atherosclerosis
- Traumatic brain injury was not associated with higher rates of amnestic mild cognitive impairment or dementia, and APOE-epsilon4 was not associated with cognition.
- falls with head injury without explicit traumatic brain injury in connection with the ApoE epsilon4 allele is associated with subsequent dementia among older adults.
- APOE epsilon 4 allele increases the risk of CSM in patients with chronic cervical spinal cord compression
- In this Brazilian population, the epsilon 4 allele in the apolipoprotein E (APOE) gene was associated with an increased risk for AD.
- The rate of brain atrophy in certain brain areas may be increased in APOE epsilon 4-positive subjects with mild cognitive impairment progressing to dementia.
- detected the carriers of the apolipoprotein E Arg136 --> Cys mutation through the population screening
- absence of the APOE epsilon 4 allele in heterozygous codon 129 PRNP carriers is a negative predictor of survival in Alzheimer's disease
- Results suggest that recycling of apolipoprotein E is not associated with cholesterol efflux in neuronal cells.
- mRNA expression of ApoE in arterial walls was not different between the controls and cerebral aneurysms.
- The APOE4 allele and life-stress factors are associated with SRH, especially in women. Physical exercise is good for health, but benefits may be attenuated among APOE4 allele carriers.
- Results compare the effect of apolipoprotein E gene polymorphism on serum lipid levels between the Chinese Guangxi Hei Yi Zhuang and Han populations.
- Results examine the frequency of apolipoprotein E4 in dementia with Lewy bodies.
- Results describe an antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.
- ApoE and ApoA1 gene variants may act synergistically to associate with risk and protection against coronary artery disease.
- APOE epsilon 4 may influence rate of cognitive decline most significantly in the earliest stages of Alzheimer disease.
- increased prevalence of APOE epsilon4 in patients with mild cognitive impairment and subjective complaints
- amyloid beta peptide association compromises the fundamental lipoprotein binding function of apoE
- APOE epsilon4 is a very strong risk factor for Alzheimer's disease (AD) in the population of central Norway. The odds ratio for developing AD increases in individuals carrying the APOE4 allele.
- We report the discovery of a genetic interaction between APOE and LHCGR alleles that is associated with a significantly decreased risk for Alzheimer's disease in males
- E2 might interact with other disease-related factors to accelerate the onset of coronary artery disease in some patients with systemic lupus erythematosus
- Data show that of four genes studied -- angiotensin-forming enzyme, PON1, PPAR-gamma, and APOE -- only PPAR-gamma and APOE showed an effect on fertility.
- APO E4 genotype and allele were found to be associated with asymptomatic obesity.
- The APOE polymorphism was statistically significantly associated with non-alcoholic steatohepatitis.
- The environmental and life-style conditions of the Kola Sami could have influenced the population-specific frequencies of the AGXTProIILeu allele, and certain alleles of APOE and LCT genes
- 'Free' copper (fC) levels were higher in Alzheimer patients and correlated with parietotemporal delta and alpha-1 activities. The correlation between fC and temporal alpha-1 activity was stronger in APOE-epsilon4 carriers.
- cognitively intact carriers of APOE-4 show regionally specific thinning of the cortical ribbon compared to APOE-3 carriers
- no association between macular degeneration and APOE polymorphism; A weak negative association between APOE4 and cataract and apolipoprotein E3 may be a protective factor against the loss of nerve fibres in the macular region
- Reduced antioxidant defense enzymatic activity and increased SOD activity increases the risk of AD in individuals who carry the APOE-4 allele.
- In this pilot study, common variants of the apolipoprotein E (APOE) and HFE genes resulting in the iron overload disorder of hereditary hemochromatosis (C282Y, H63D and S65C) were evaluated as factors in sporadic AD in an Ontario sample.
- These findings suggest that Apo e4 exerts a regionally selective effect on CA3&DG in normal aging and AD.
- Data show that the ApoE epsilon4 allele frequency is significantly higher in the Alzheimer's disease patients than in the non-Alzheimer dementia patients or in the control groups.
- The APOE epsilon4/epsilon4 genotype is associated with an accelerated disease course and especially progression to death compared with the APOE epsilon3/epsilon3 genotype.
- Data show that Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.
- Among 100 stroke patients and 30 healthy subjects included in the study, most frequent Apo E genotype was epsilon3/3; polymorphisms were associated with lipid profiles and homocysteine levels.
- APOE epsilon4 allele was associated with differences in neurological recovery and longer rehabilitation LOS. Genetic factors may be among the determinants of outcome after SCI and warrant further study.
- ApoE is not associated with the development of schizophrenia (OR 1.04, CI 95%=0.90-1.21, p=0.184) in the absence of heterogeneity (chi2=18.8, df=18, p=0.4).
- In adjusted models, while a higher cortisol level was associated with worse cognitive scores, the slopes of the adverse relations were steeper in persons with at least one APOE-epsilon4 allele.
- The diagnostic performance of hsCRP in distinguishing 3-vessel coronary artery disease from less extensive forms of coronary atherosclerosis is more accurate in a group of subjects without the apoE epsilon4 allele than in patients with it.
- There is no important association between carrying the apolipoprotein epsilon 4 allele and sustaining a concussion
- The presence of the APOE epsilon4 allele is associated with impaired memory functioning in both middle-aged and old subjects with mild cognitive impairment, although the memory function affected varies with age
- It is possible that APOE*E4 carriers become vulnerable to greater cognitive decline in the presence of other risk factors at 65-69 years of age
- These observations suggest that there is an interactive effect between APOE and LIPC genotypes on plasma triglyceride levels.
- The presence of an ApoE epsilon4 allele was associated with an increased frequency of coexistent LBD.
- Among plasma proteins, apoE is one of the preferred substrates of matrix metalloproteinase (MMP)-14, and also of MMP-7 and MMP-2, to a lesser extent.
- no major influence of APOE epsilon4 on disease risk was detected, a gene dose-dependent effect with lower age at onset of sporadic ALS in epsilon4 carriers was found (p=0.027). These data support APOE epsilon4 as a subordinate contributing factor in ALS.
- A combined effect of APOE and IL1B allelic variants has been discovered indicating the increased risk of the disease development in the carriers of APOE*4 and IL1B*T/*T alleles (OR = 4.76).
- article reviews the current understanding of the genetic susceptibility of traumatic brain injury (TBI) and the advancements regarding the impact of apolipoprotein E genotype on the severity and/or outcome following TBI [review]
- The APOE epsilon4 status modifies the association between depressive symptoms and dementia in elderly men.
- results show an role of apoE4 C-terminal segments in secondary structure stability and unfolding and suggest that interactions mediated by the C-terminal segments are important for the structural integrity and conformational changes of apoE4
- CRP is higher in apo E3/3 than in 3/4 subjects and in women compared with men, but remains unchanged by 6 months of standard aerobic exercise training to reduce cardiovascular disease risk. How apo E genotype affects CRP is not known.
- APO E polymorphism is associated with the development of traumatic brain injury -induced pituitary dysfunction
- The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5).
- Within the coding sequence of APOE we identified an enhancer for the E4 allele associated with Alzheimer's disease, but not E3. A SNP causing the E4/E3 amino acid substitution was responsible for these variations, and higher expression levels of E4.
- Our study suggests that LRPAP1-D and APOE E4 alleles significantly increase the susceptibility to degenerative dementias.
- Preexisting cognitive impairment and postoperative cognitive dysfunction are not associated with APOE epsilon4 genotype, suggesting that cognitive impairment both before and after CABG may not be associated with degenerative cognitive decline.
- a low adiponectin state is associated with metabolic abnormalities in obese children, particularly depending on apolipoprotein E phenotype
- Study shows a significant increase in intracerebral hemorrhage in human apoE4 targeted replacement mice compared with apoE3 mice.
- Report the anticoagulant effect of dietary fish oil in hyperlipidemia: a study of hepatic gene expression in apolipoprotein E2 (APOE2) knock-in mice.
- Apo E gene expression and protein concentration were higher in non-small cell lung cancer tissue than in adjacent non-cancer tissue; increase of apo E concentration in the cancer tissue correlated with the decrease of apo E protein in the serum
- APOE genotype influences chronic lymhocytic leukemia outcome and response to therapy, it does not alter susceptibility to developing this disease
- Data show that the apolipoprotein E epsilon3/epsilon4 genotype is more frequently seen in the simple febrile than in the complicated febrile convulsion group.
- Apolipoprotein E genotype is not associated with cerebral palsy.
- Adipo-inductive media or dexamethasone induced sustained secretion of apolipoprotein E in mesenchymal stromal cells and the duration of secretion was only limited by the length of time mesenchymal stromal cells could be sustained in culture.
- Data show the modulating effects of apolipoprotein E polymorphisms on secondary brain insult and outcome after childhood brain trauma.
- Our findings support the hypothesis that the ApoE genotype in mild cognitive impairment might be associated with structural changes typically found in the early stages of Alzheimer's disease
- Results suggest a possible influence of APOE genotype on nitric oxide production that might enhance the effects of age-related specific factor(s) associated with neurodegenerative disorders.
- Significant differences were observed for genotype and allele distributions of APOE epsilon2/epsilon3/epsilon4 polymorphism in patient with stroke in chinese.
- The preferential interaction of the P. falciparum PFE1590w protein with the human ApoE epsilon3 and ApoE epsilon4 isoforms, but not the ApoE epsilon2 isoform, supports the hypothesis that ApoE genotype affects risk of malaria infection.
- individuals showed Presenilin 1 polymorphism to be associated with Alzheimer's disease in an apolipoprotein E specific manner
- The slightly altered structural properties of apoE4-mut2 are associated with slightly reduced binding of this protein to TG-rich lipoprotein particles and milder hypertriglyceridemia as compared with WT apoE4.
- Genome-wide association study reveals putative Alzheimer disease susceptibility loci in addition to APOE.
- Evidence of an effect of APOE status on the relationship between stress and cognitive functioning despite a number of differences in study design.
- The results indicate that low birth weight has a deleterious influence on lipid profile particularly in adolescents with the APOE epsilon3/epsilon4 genotype
- APOE2/3 blacks may benefit more from aerobic fitness to reduce cardiovascular risk.
- ApoE may have a role in muscular invasion of gastric cancer
- Outcome demonstrated that patients with APOE epsilon4 had worse outcome vs. those lacking this allele.
- APOE genotypes may be associated with the psychosocial and neurocognitive performance after spontaneous nonaneurysmal SAH, even in the absence of neurological impairment.
- Apo E4 polymorphism may contribute to the thrombophilic risk factors contributing to recurrent pregnancy loss
- These findings indicate that the effects of tamoxifen on plasma triglyceride levels in breast cancer patients are modified by APOE polymorphism.
- Older age was associated with increased lateral temporal FDDNP binding. Carriers of APOE-4 demonstrated higher frontal FDDNP binding than noncarriers.
- an association between apo E polymorphism and CETP activity and this association did not affect the relationship between apo E polymorphism and triglyceride and HDL cholesterol concentrations.
- APOE*4 allele is not assosiated with risk of development of the multiple sclerosis at ethnic Russians.
- ApoE single nucleotide polymorphisms were not associated with increased Common carotid intima-media thickness.
- Demonstrated the existence of the synergistic effect between cigarett smoking and the contemporaneous carrier-state of APOE epsilon4 ellele which increased the risk of coronary artery disease.
- These observations suggest that the preferential binding of apoE to oxidized phospholipid containing membrane may play a role in the anti-oxidative properties of apoE.
- Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia
- Our observations suggest that elderly people in long-term care hospitals in Japan may be repeatedly infected with hMPV and that the ApoE-varepsilon4 allele might be one of the host factors related to hMPV susceptibility.
- influence of APOE epsilon4 on the risk of Alzheimer's disease was independent of homocysteine, vitamin B12 levels and MTHFR status.
- In this population of elderly women, although having at least one epsilon4 allele increased the chances of an earlier death, having dementia increased the risk of death regardless of APOE genotype.
- Polymorphsms may increase risk of myocardial infarct.
- In old age, high serum calcium levels associate with worse cognitive function especially in APOE epsilon4 allele carriers, but not in carriers of the epsilon2 allele.
- In the oldest old, the presence of the APOE epsilon2 allele is associated with reduced risk of dementia, but increased Alzheimer's disease neuropathology.